A Low-cost, Intravascular Ultrasound Transducer System for Measuring Blood Flow

用于测量血流的低成本血管内超声换能器系统

• 批准号: 7611201
• 负责人: John Blebea
• 金额: $ 12.52万
• 依托单位: DVX, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-16 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7611201
• 关键词: Angioplasty; Animals; Biocompatible; Blood; Blood Vessels; Blood flow; Caliber; Canis familiaris; Caregivers; Catheters; Clinical; Devices; Electrodes; Ensure; Feedback; Frequencies; Goals; Implant; Intervention; Lead; Life; Light; Liquid substance; Manufacturer Name; Measurement; Measures; Modeling; Monitor; Operative Surgical Procedures; Pacemakers; Paper; Performance; Phase; Physiological; Procedures; Resources; Stents; Surgeon; System; Technology; Testing; Thrombectomy; Transducers; Ultrasonic Transducer; Ultrasonography; United States; United States National Institutes of Health; Work; blood flow measurement; cost; design; flexibility; iliac artery; improved; meetings; minimally invasive; prevent; programs; public health relevance; retinal rods; success; wound

DESCRIPTION (provided by applicant): Over a million minimally invasive procedures to preserve blood flow - angioplasties, stent placements, thrombectomies - are performed each year in the United States. The goal of this program is to provide means of measuring blood flow in these vessels during and after these procedures, something now not possible. We have developed a new blood-flow measuring component that can be integrated into minimally invasive interventional devices. During the procedure, it provides quantitative feedback to the operator on success in restoring blood flow; after the procedure, it can be remain as an indwelling lead to measure blood flow post-operatively. Its low power requirement also makes it suitable for long-term implantable use -- a small implanted unit, like a pacemaker, can monitor flow and wirelessly communicate an alert when declining blood flow demands intervention. This intravascular blood-flow measuring device is a newly developed, unique ultrasound transducer system. The design utilizes the principle of diffraction-grating transducers, which have been proven to measure blood flow accurately. A special configuration has been invented to make the transducer suitable for intravascular use: the electrodes on this transducer are wound around a rod, in helices, like a screw thread. This design has several advantages: it allows piezoplastics to be used at high frequencies, leading to low power requirements; use of piezoplastics makes a light, flexible device possible; it is easy to connect to; and, importantly, it is inexpensive to fabricate. Phase I of this project is to prove the concept by fabricating these transducers and demonstrating their capabilities in test phantoms, followed by placing one by minimally invasive means in a living animal and demonstrating successful blood flow measurement. PUBLIC HEALTH RELEVANCE: The goal of this program is to develop an intravascular device to measure blood flow during and after operations that improve or restore blood flow. By monitoring blood flow and alerting caregivers to a problem, it can prevent the serious consequences of too little flow of blood.

描述（由申请人提供）：美国每年进行超过一百万例用于保留血流的微创手术——血管成形术、支架置入术、血栓切除术。该计划的目标是提供在这些手术期间和之后测量这些血管中的血流量的方法，但现在这是不可能的。我们开发了一种新的血流测量组件，可以集成到微创介入设备中。在手术过程中，它向操作者提供有关血流恢复成功的定量反馈；手术后，它可以作为留置导线保留以测量术后血流量。其低功耗要求也使其适合长期植入使用——一个小型植入装置，如起搏器，可以监测血流，并在血流下降需要干预时以无线方式发出警报。这种血管内血流测量装置是一种新开发的、独特的超声换能器系统。该设计利用了衍射光栅传感器的原理，该原理已被证明可以准确测量血流。我们发明了一种特殊的配置，使换能器适合血管内使用：该换能器上的电极以螺旋状缠绕在一根杆上，就像螺纹一样。这种设计有几个优点：它允许压电塑料在高频下使用，从而降低功率要求；压电塑料的使用使得轻质、灵活的设备成为可能；易于连接；而且重要的是，它的制造成本低廉。该项目的第一阶段是通过制造这些传感器并在测试模型中展示其功能来证明这一概念，然后通过微创方式将其放置在活体动物体内并展示成功的血流测量。公众健康相关性：该计划的目标是开发一种血管内装置，用于测量改善或恢复血流的手术期间和手术后的血流量。通过监测血流并向护理人员发出问题警报，可以防止血流过少造成的严重后果。