Life Course Developmental and Reproductive Predictors of Increased Mammographic Breast Density in Black Women

黑人女性乳房 X 线摄影乳房密度增加的生命历程发育和生殖预测因子

基本信息

批准号：
10604784
负责人：
Zahna Bigham
金额：
$ 4.77万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-16 至 2027-03-15
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10604784
关键词：
Address Adult Age Age at Menarche Asian Biological Biology Biometry Birth Body mass index Breast Breast Cancer Prevention Breast Cancer Risk Factor Breast Cancer Treatment Breast Feeding Characteristics Childhood Coupling Data Development Developmental Course Diagnosis Discrimination Disparity Doctor of Philosophy Environment Environmental Exposure Epidemiologic Methods Epidemiology Etiology European ancestry Exhibits Exposure to First Births Funding Future General Population Goals Growth and Development function Health Disparities Research Healthcare Systems Height High birth weight infant Incidence Integration Host Factors Intervention Investigation Lead Learning Life Cycle Stages Literature Mammographic Density Mammography Mediator Menarche Parents Participant Pattern Physicians Population Predisposition Pregnancy Prevention Preventive healthcare Puberty Race Recording of previous events Reproductive History Research Research Personnel Risk Factors Risk Reduction Sample Size Scientist Sexual Development Sexual Maturation Social Behavior Somatotype Structural Racism Surrogate Endpoint Techniques Testing Time Training United States Vulnerable Populations Waist-Hip Ratio Weight Woman Women&apos s Health Work analytical tool biobehavior black women breast density cancer health disparity cancer risk cancer therapy career clinical training cohort density digital emerging adult experience human old age (65+)improved insight malignant breast neoplasm mortality novel obesity in children parity public health intervention racial population repository reproductive reproductive outcome skills social social disparities social health determinants survival disparity

项目摘要

PROJECT SUMMARY/ABSTRACT Despite improvements in breast cancer incidence and mortality rates in the general population, breast cancer incidence rates in Black women have continued to rise and they exhibit the highest breast cancer mortality rate out of any other racial population. Increased mammographic density has been well established as one of the strongest, independent breast cancer risk factors. However, to date, there have been very few studies that have included Black women in our understanding of mammographic breast density, which is a significant limitation given that Black women are more likely to have denser breasts. Breast cancer disparities are likely multifactorial and driven by related combinations of social determinants of health, the paucity of data in Black women has resulted in a limited understanding of the contribution of breast density to cancer disparities. While race, a social construct, is an unlikely direct predictor of mammographic density, it can serve as a marker of differential lived experiences due to various cultural practice, environmental exposures, and experiences of structural racism. Childhood, puberty, and pregnancy represent times of increased breast development and susceptibility to such exposures and host factors. In fact, Black women display differing anthropometric and reproductive patterns – which are known contributors to mammographic density in white women – across their life course. We hypothesize that unique distributions of body and sexual maturation characteristics during childhood and puberty, and varying reproductive outcomes during adulthood may, in part, explain the increased incidence of high mammographic density in Black women. Using the Black Women’s Health Study, the largest cohort of Black women in the United States (59,000 women), we have developed a large mammogram repository consisting of over 10,000 participants. Leveraging this analytic tool, in Aim 1, we will determine the associations of anthropometric, body habitus, and sexual development characteristics across the life course with percent and absolute mammographic density. Aim 2 will explore the association between specific pregnancy-related characteristics and percent and absolute mammographic density. This will be the first study to assess factors from birth to adulthood as predictors of mammographic density in Black women. Successful completion of these aims will offer insight into the etiology of increased mammographic density in Black women and contribute to a better understanding of breast cancer incidence and survival disparities in this vulnerable population. This proposal also integrates advanced epidemiologic techniques and fundamental biostatistical skills with clinical training to prepare the PI for a career as an independent physician scientist with expertise in cancer health disparities research.

项目概要/摘要尽管一般人群的乳腺癌发病率和死亡率有所改善，但乳腺癌黑人女性的发病率持续上升，她们的乳腺癌死亡率最高乳房X线照相密度的增加已被确定为任何其他种族人口中的一个。最强的、独立的乳腺癌危险因素然而，迄今为止，很少有研究表明。我们对乳房 X 线摄影乳房密度的理解中包括了黑人女性，这是一个重要的鉴于黑人女性的乳房密度更大，乳腺癌的差异可能存在。黑人数据的缺乏是多因素的，并由健康的社会决定因素的相关组合驱动女性对乳房密度对癌症差异的影响了解有限。种族是一种社会建构，不太可能直接预测乳房 X 光密度，但它可以作为由于不同的文化习俗、环境暴露和经历而导致不同的生活经历儿童期、青春期和怀孕期是乳房发育和发育加快的时期。对此类暴露和宿主因素的易感性事实上，黑人女性表现出不同的人体测量和特征。生殖模式（众所周知，这是白人女性乳房X光密度的影响因素）我们在生命历程中追求身体和性成熟特征的独特分布。童年和青春期以及成年期间不同的生殖结果可能在一定程度上解释了使用黑人女性健康研究，黑人女性的高乳房X线密度发生率增加。作为美国最大的黑人女性群体（59,000 名女性），我们开发了一个大型由 10,000 多名参与者组成的乳房 X 光照片存储库，在目标 1 中，我们将利用此分析工具。确定人体测量、身体习惯和性发育特征之间的关联目标 2 将探讨生命历程与百分比和绝对乳房 X 光密度之间的关联。特定的妊娠相关特征以及百分比和绝对乳房X线密度。第一项研究评估从出生到成年的因素作为黑人女性乳房X光密度的预测因素。成功完成这些目标将有助于深入了解乳腺 X 光密度增加的病因。黑人女性，有助于更好地了解乳腺癌发病率和生存差异该提案还整合了先进的流行病学技术和基础知识。生物统计技能和临床培训，为 PI 成为独立医师科学家的职业做好准备癌症健康差异研究方面的专业知识。