Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

指导结核病、艾滋病毒和全球健康领域的多学科、以患者为导向的研究

• 批准号: 10619230
• 负责人: Nippie Sarita Shah
• 金额: $ 19.53万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-23 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619230
• 关键词: Affect; Area; Base Pairing; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Data; Clinical Research; Clinical Trials; Clonal Expansion; Collaborations; Communicable Diseases; Communities; Data; Diagnosis; Disease; Drug resistance in tuberculosis; Ensure; Environment; Epidemic; Epidemiologist; Epidemiology; Extreme drug resistant tuberculosis; Foundations; Funding; Funding Opportunities; Genomics; Goals; HIV; HIV/TB; Health; Health Policy; Household; Immunology; Incidence; Individual; Interdisciplinary Study; International; K-Series Research Career Programs; Knowledge; Lead; Link; Location; M. tuberculosis genome; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular Epidemiology; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mycobacterium tuberculosis; Parents; Participant; Patient Care; Pattern; Persons; Pharmacology; Physicians; Policies; Prevention; Public Health; Research; Research Infrastructure; Resources; Rifampicin resistance; Role; Science; Scientific Advances and Accomplishments; Scientist; Social Mobility; South Africa; Specimen; Structure; Time; Training; Treatment outcome; Tuberculosis; United States National Institutes of Health; Universities; Work; career; career development; co-infection; community setting; design; detection limit; effective intervention; epidemiologic data; epidemiology study; experience; genome sequencing; global health; improved; innovation; insight; interest; mathematical model; multidisciplinary; mycobacterial; next generation; novel; novel diagnostics; novel therapeutics; patient oriented; patient oriented research; prevent; programs; research study; resistant strain; skills; social; social contact; success; training opportunity; transmission process; whole genome

Dr. Shah is a physician-scientist with 15 years of experience leading patient-oriented research (POR) on diagnosis, treatment, and prevention of tuberculosis (TB) globally, including drug-resistant TB and TB/HIV co- infection. Her experience with U.S. and international public health programs, including the Centers for Disease Control & Prevention (CDC) where she trained and worked for a decade, provides a strong foundation for integrating research into policy and patient care. This K24 award will allow her to enhance and expand her successful mentorship in POR by providing vital protected time for training in advanced methods for studying TB transmission, and developing a structured mentoring program. Worldwide, TB is the leading cause of death among people living with HIV, with drug-resistant TB threatening decades of progress in TB and HIV control. Drug-resistant TB epidemics are driven primarily by person-to-person transmission of resistant strains, and innovative approaches to improve our understanding of TB transmission are urgently needed to guide effective interventions. Similarly, there is a need to train the next generation of scientists in multidisciplinary TB/HIV and global health POR. Dr. Shah’s robust research program supported by NIH, Gates Foundation, and CDC provides exciting training opportunities that attract trainees interested in multidisciplinary TB & HIV POR. She has a strong track record of mentorship of U.S. and international trainees in diverse areas of TB & HIV clinical research, and many of her mentees have pursued academic careers and K awards. In addition, through her role as Director of the Clinical Core for the NIH P30 Emory/Georgia TB Research Advancement Center and mentor on D43 and T32 programs, she is well placed to provide outstanding research and training opportunities. Biospecimens, clinical, and epidemiologic data from Dr. Shah’s ongoing NIH R01-funded CONTEXT study provide new opportunities for insights into TB transmission, including the impact of the COVID-19 pandemic on social contact patterns that are a key factor in disease spread. The CONTEXT study will serve as the parent study for the new research proposed in this K24 that will: 1) characterize Mtb genomic relatedness using long-read sequencing and evaluate the impact on transmission networks; and 2) characterize changes in social contact patterns during the COVID-19 pandemic and estimate the impact on TB incidence. Each aim is designed to integrate mentees who have experience and interest in growing their careers in these emerging areas of TB transmission science. Dr. Shah’s research and mentoring program is facilitated by her long-standing, cross-disciplinary collaborations with leading experts in mycobacterial genomics, pharmacology, immunology, clinical trials, and mathematical modeling. In addition, the outstanding training resources, funding opportunities, and research infrastructure at Emory will be integrated into Dr. Shah’s mentoring program to create an environment that enables the success of her trainees to pursue independent, impactful careers in TB, HIV, and global health POR.

Shah 博士是一位医师科学家，拥有 15 年领导以患者为导向的研究 (POR) 的经验 全球结核病 (TB) 的诊断、治疗和预防，包括耐药结核病和结核病/艾滋病毒合并 她在美国和国际公共卫生项目（包括疾病中心）的经验。 她在控制与预防 (CDC) 接受培训并工作了十年，为她的 该 K24 奖项将使她能够将研究融入政策和患者护理中，从而提高和扩展她的研究能力。 通过为先进学习方法的培训提供重要的受保护时间来成功指导 POR 结核病传播，并制定结构化指导计划 在世界范围内，结核病是导致死亡的主要原因。 在艾滋病毒感染者中，耐药结核病威胁着数十年来在结核病和艾滋病毒控制方面取得的进展。 耐药结核病流行主要是由耐药菌株的人际传播驱动的，并且 迫切需要创新方法来提高我们对结核病传播的了解，以指导有效的 同样，需要培训下一代结核病/艾滋病毒和艾滋病毒多学科科学家。 全球健康 POR。Shah 博士的强大研究计划得到了 NIH、盖茨基金会和 CDC 的支持。 提供令人兴奋的培训机会，吸引对多学科结核病和艾滋病毒 POR 感兴趣的学员。 在结核病和艾滋病毒临床各个领域对美国和国际学员进行指导方面拥有良好的记录 此外，她的许多弟子还通过她从事学术事业并获得 K 奖。 担任 NIH P30 埃默里/佐治亚州结核病研究进展中心临床核心主任， D43 和 T32 项目的导师，她非常适合提供出色的研究和培训 Shah 博士正在进行的 NIH R01 资助的生物样​​本、临床和流行病学数据。 背景研究为深入了解结核病传播提供了新的机会，包括结核病的影响 COVID-19 大流行对社会接触模式的影响是疾病传播的关键因素。 将作为本 K24 中提出的新研究的父研究，该研究将：1) 表征 Mtb 基因组 使用长读长测序的相关性并评估对传输网络的影响；2) 描述 COVID-19 大流行期间社会接触模式变化的特征并估计其对结核病的影响 每个目标都旨在整合有经验且有兴趣发展自己的学员。 沙阿博士的研究和指导计划是结核病传播科学这些新兴领域的职业生涯。 她与分枝杆菌领域的领先专家长期的跨学科合作促进了这一工作 此外，基因组学、药理学、免疫学、临床试验和数学建模也很突出。 埃默里大学的培训资源、资助机会和研究基础设施将整合到 Dr. 沙阿的指导计划旨在创造一个环境，使她的学员能够追求成功 在结核病、艾滋病毒和全球卫生 POR 领域拥有独立、有影响力的职业生涯。