Intravital Microscopy Core

活体显微镜核心

基本信息

批准号：
10926657
负责人：
Roberto Weigert
金额：
$ 31.08万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10926657
关键词：
Anaphase Animal Model Animals Apoptosis B-Lymphocytes CCR Cell Cycle Cell physiology Data Analyses Development Disease Embryo Experimental Designs Extracellular Matrix Glycogen storage disease type II Human Image Immune system In Situ Investigation Malignant Neoplasms Messenger RNA Mission Mus National Heart, Lung, and Blood Institute Neoplasm Metastasis Neutrophil Infiltration Organ Pathologic Peripheral Pharmaceutical Preparations Physiological Procedures Research Personnel Rhabdomyosarcoma Rodent Model Role Skin Squamous cell carcinoma Time Tissues Transgenic Animals Tumor Cell Invasion Visualization Xenograft Model cellular imaging drug efficacy efficacy testing high resolution imaging imaging approach in vivo intravital imaging intravital microscopy lung cancer cell malignant breast neoplasm mechanical properties melanoblast melanoma migration multimodality novel tumor tumor growth tumor initiation tumor microenvironment tumor progression wound healing

项目摘要

In the last year, the CCR IVM Core has been completing the following 8 projects: 1) Role of peripheral mRNAs in controlling tumor invasion and metastasis - Investigator Voula Mili (LCMB) 2) Intravital imaging of drug-induced Anaphase Catastrophe in human Lung Cancer Cells expressing Fucci-4 in Xenograft models - Investigator Ethan Dimitorvsky (Frederick National Lab) 3) Role of Smurf2 during wound healing - Investigator -Ying Zhang (LCMB) 4) Role of ASAP1 in the progression of Rhabdomyosarcomas (RBDs). - Investigator Paul Randazzo (LCMB) 5) Imaging mechanical properties of tumor microenvironment during melanoma progression - Investigator Glenn Merlino LCBG 6) Role of Trail during neutrophil infiltration in breast cancer. Investigator Stan Lipkowitz (WMB); 7) Role of PKI in basal squamous cell carcinoma in the skin; Investigator Ramiro Iglesias-Barolome (LCMB) 8) Imaging cell cycle during tumor progression. Investigator, Steven Cappell (LCBG) And initiated the following 4 projects: 1) Role of GEMesys in blocking tumor growth - Investigator Rosandra Kaplan (POB) 2) B-Cell Apoptosis in vivo - Investigator Christian Meyer (EIB) 3) Imaging melanoblasts migration in live mouse embryo in situ -Investigator Glenn Merlino LCBG 4) Imaging Pompe diseases in live mice - Investigator Rosa Puetollano (NHLBI)

去年，CCR IVM 核心完成了以下 8 个项目： 1) 外周 mRNA 在控制肿瘤侵袭和转移中的作用 - 研究员 Voula Mili (LCMB) 2) 药物诱导的人类肺癌后期灾难的活体成像在异种移植模型中表达 Fucci-4 的细胞 - 研究员 Ethan Dimitorvsky（弗雷德里克国家实验室）3) Smurf2 在移植过程中的作用伤口愈合 - 研究员 - 张英 (LCMB) 4) ASAP1 在横纹肌肉瘤 (RBD) 进展中的作用。 - 研究员 Paul Randazzo (LCMB) 5) 黑色素瘤进展过程中肿瘤微环境的成像机械特性 - 研究员 Glenn Merlino LCBG 6) Trail 在乳腺癌中性粒细胞浸润过程中的作用。研究员 Stan Lipkowitz (WMB)； 7) PKI在皮肤基底鳞状细胞癌中的作用；研究员 Ramiro Iglesias-Barolome (LCMB) 8) 肿瘤进展过程中的细胞周期成像。研究员 Steven Cappell (LCBG) 并启动了以下 4 个项目： 1) GEMesys 在阻止肿瘤生长中的作用 - 研究员 Rosandra Kaplan (POB) 2) 体内 B 细胞凋亡 - 研究员 Christian Meyer (EIB) 3) 成黑素细胞迁移成像活体小鼠胚胎原位 - 研究员 Glenn Merlino LCBG 4) 对活体小鼠庞贝病进行成像 -调查员 Rosa Puetollano (NHLBI)