Intravital Microscopy Core

活体显微镜核心

• 批准号: 10487273
• 负责人: Roberto Weigert
• 金额: $ 8.74万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487273
• 关键词: Anaphase; Animal Model; Animals; CCR; Cell physiology; Data Analyses; Development; Disease; Experimental Designs; Extracellular Matrix; Human; Image; Immune system; Investigation; Malignant Neoplasms; Messenger RNA; Mission; Neoplasm Metastasis; Neutrophil Infiltration; Organ; Pathologic; Peripheral; Pharmaceutical Preparations; Physiological; Procedures; Research Personnel; Rhabdomyosarcoma; Rodent Model; Role; Time; Tissues; Transgenic Animals; Tumor Cell Invasion; Xenograft Model; drug efficacy; efficacy testing; high resolution imaging; imaging approach; intravital imaging; intravital microscopy; lung cancer cell; malignant breast neoplasm; mechanical properties; melanoma; multimodality; novel; tumor; tumor initiation; tumor microenvironment; wound healing

Since its inception, the CCR IVM Core has been developing the following 6 projects: 1) Role of peripheral mRNAs in controlling tumor invasion and metastasis - Investigator Voula Mili (LCMB) 2) Intravital imaging of drug-induced Anaphase Catastrophe in human Lung Cancer Cells expressing Fucci-4 in Xenograft models - Investigator Ethan Dimitorvsky (Frederick National Lab) 3) Role of Smurf2 during wound healing - Investigator -Ying Zhang (LCMB) 4) Role of ASAP1 in the progression of Rhabdomyosarcomas (RBDs). - Investigator Paul Randazzo (LCMB) 5) Imaging mechanical properties of tumor microenvironment during melanoma progression - Investigator Glenn Merlino LCBG 6) Role of Trail during neutrophil infiltration in breast cancer. Investigator Stan Lipkowitz (WMB)

自成立以来，CCR IVM 核心一直在开发以下 6 个项目： 1) 外周 mRNA 在控制肿瘤侵袭和转移中的作用 - 研究者 Voula Mili (LCMB) 2) 人肺癌细胞中药物诱导的后期灾难的活体成像在异种移植模型中表达 Fucci-4 - 研究员 Ethan Dimitorvsky（弗雷德里克国家实验室）3) Smurf2 在伤口愈合 - 研究员 - 张英 (LCMB) 4) ASAP1 在横纹肌肉瘤 (RBD) 进展中的作用。 - 研究员 Paul Randazzo (LCMB) 5) 黑色素瘤进展过程中肿瘤微环境的成像机械特性 - 研究员 Glenn Merlino LCBG 6) Trail 在乳腺癌中性粒细胞浸润过程中的作用。调查员斯坦·利普科维茨 (WMB)