ONTOGENY OF LIMBIC SEIZURES

边缘系统癫痫发作的个体发生

• 批准号: 3414537
• 负责人: EDWARD H BERTRAM
• 金额: $ 12.82万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-25 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3414537
• 关键词: anticonvulsants; chronic disease /disorder; computer assisted diagnosis; disease /disorder model; electroencephalography; epilepsy; hippocampus; laboratory rat; limbic system; longitudinal human study; model design /development; monitoring device; neuroanatomy; nonhuman therapy evaluation; online computer; relapse /recurrence; videotape /videodisc

This study is designed to examine the events leading up to behavioral seizures, the subsequent development of the mature epileptic state and the possible effects standard anticonvulsants may have on this evolution using a newly developed animal model of partial seizures. Partial epilepsy represents the most common chronic seizure disorder which is refractory to standard therapy, but little is known about the mechanisms leading up to spontaneous seizures or about the natural history of the disease once it is established. In the course of this project the following topics will be examined. 1)The events preceding the first behaviorally apparent seizure are unknown. It has been hypothesized that the first overt manifestations are preceded by a number of subclinical electrographic seizures which intensify in a kindling like process. This question will be examined by determining whether a number of electrographic seizures occur before the first motor seizure. 2) One theory has long held that there is a tendency for seizures to worsen over time, although remissions have also been achieved. The second experiment will follow the natural history of this seizure model to determine whether seizure frequency increases with succeeding seizures. 3) Prophylactic or early treatment has been advocated as a means of lessening the severity of the disease, but its use is controversial. This experiment will determine the role of anticonvulsant therapy in changing the natural history of the seizures established in the first 2 experiments. These experiments will examine these critical questions in the ontogeny of partial seizures using the new long term monitoring technology, providing new insights into the mechanisms leading to the chronic epileptic state.

本研究旨在检查导致行为的事件 癫痫发作、成熟癫痫状态的后续发展以及 标准抗惊厥药可能对这种进化产生可能的影响 新开发的部分性癫痫动物模型。部分性癫痫 代表最常见的慢性癫痫病，难以治愈 标准疗法，但对于导致这一现象的机制知之甚少 自发性癫痫发作或有关疾病的自然史 已确立的。在该项目的过程中，将讨论以下主题 检查了。 1）第一次明显行为癫痫发作之前的事件未知。 据推测，第一次明显的表现先于 由许多亚临床电图癫痫发作引起，这些癫痫发作在 类似点燃的过程。这个问题将通过确定 在第一次运动之前是否发生多次电图癫痫发作 发作。 2) 长期以来，一种理论认为癫痫发作有恶化的趋势 随着时间的推移，虽然也取得了缓解。第二个 实验将遵循该癫痫模型的自然史 确定癫痫发作频率是否随着连续癫痫发作而增加。 3) 提倡预防或早期治疗作为一种手段 减轻疾病的严重程度，但其使用存在争议。这 实验将确定抗惊厥治疗在改变中的作用 前 2 个实验中确定的癫痫发作的自然史。 这些实验将研究个体发育中的这些关键问题 使用新的长期监测技术，提供部分癫痫发作 对导致慢性癫痫状态的机制的新见解。