Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda

加强行为和社会科学研究能力，应对乌干达艾滋病毒护理和预防方面不断变化的挑战

• 批准号: 10872340
• 负责人: Carol Suzanne Camlin
• 金额: $ 10万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10872340
• 关键词: Acceleration; Address; Ageism; Aging; Area; Behavioral; California; Caring; Collaborations; Complex; Data; Effectiveness; Elderly; Faculty; Fellowship; Future; HIV; Health; Intervention; Leadership; Master of Science; Mentorship; Nature; Older Population; Persons; Population; Postdoctoral Fellow; Prevention; Process; Productivity; Research; Research Personnel; Research Training; Resource-limited setting; Resources; San Francisco; Social isolation; Training; Training Programs; Uganda; Universities; antiretroviral therapy; behavioral and social science; biomedical scientist; collaborative environment; comorbidity; design; high risk; interest; next generation; programs; scale up; social; social science research; social stigma; success

Project summary: The effectiveness of and increased access to antiretroviral therapy (ART) has resulted in longer, healthier, and more productive lives for people living with HIV (PLHIV). However, this success presents unexpected consequences of a growing population of people aging with HIV. Challenges of aging with HIV include a high risk of co-morbidities, a double burden of intersectional stigma related to both aging and HIV, and an accelerated aging process. Previous research has shown that older PLHIV are more likely to be socially isolated. The intersection of HIV-related stigma and ageism is a complex issue requiring further research on the design and feasibility of implementing stigma reduction interventions. There is also an urgent need for research to address critical gaps in our understanding of the impacts of aging on the health of PLHIV and the nature of the accelerated aging process in PLHIV. There is therefore a need to train the next generation of researchers to address these challenges and to design, implement, and scale-up tailored and context-specific interventions for the growing population of older PLHIV in Uganda and similar resource-limited settings. In the past 4 years, we have established a comprehensive research-training program at Makerere University (Mak) with emphasis on strengthening leadership and expertise in Behavioral and Social Sciences Research (BSSR-D43TW011304) to address the evolving challenges in HIV care and prevention in Uganda. We have built on longstanding and productive collaborations between faculty at Mak and the University of California San Francisco (UCSF), to provide a suitable environment for interdisciplinary training in BSSR. We propose to continue the program and focus the next year and a renewal application to address the challenges of HIV and aging. We propose a one-year supplement to spur interest in research on HIV and aging and to obtain preliminary data to inform future long-term research training in this area. Specifically, we aim to: 1) broaden the MakBSSR training program to include research training on HIV and aging, ageism, and intersectional stigma, 2) provide research training and mentorship to masters and postdoctoral fellowship trainees to address the evolving challenges of HIV and aging in Uganda and, 3) prepare a renewal application of the MakBSSR research training program focused on aging with HIV, ageism and intersectional stigma. This supplement will leverage existing resources of the MakBSSR program including collaborations among social, behavioral, and biomedical scientists at Mak, collaborating HIV programs, and partner universities in the USA. During the one-year supplement, we plan to train one master’s degree candidate and two post-doctoral fellowship trainees, all at Mak.

项目概要： 抗逆转录病毒疗法 (ART) 的有效性和获得性的增加导致了更长的、 然而，这一成功表明艾滋病毒感染者 (PLHIV) 的生活更健康、更富有成效。 感染艾滋病毒的老龄人口数量不断增加带来的意想不到的后果。 包括合并症的高风险、与老龄化和艾滋病毒相关的交叉耻辱的双重负担， 先前的研究表明，老年感染者更有可能加速衰老。 与艾滋病毒相关的耻辱和年龄歧视的交叉是一个需要进一步解决的复杂问题。 还有一项关于实施减少耻辱干预措施的设计和可行性的研究。 迫切需要开展研究来弥补我们对衰老对健康影响的理解上的重大差距 因此，有必要对 PLHIV 的认识和 PLHIV 加速衰老过程的性质进行培训。 下一代研究人员应对这些挑战并设计、实施和扩大规模 针对乌干达和类似地区不断增长的老年感染者艾滋病毒感染者量身定制和针对具体情况的干预措施 资源有限的设置。 在过去的 4 年里，我们在麦克雷雷建立了全面的研究培训项目 大学（Mak），重点加强行为和社会方面的领导力和专业知识 科学研究 (BSSR-D43TW011304) 应对艾滋病毒护理和预防中不断变化的挑战 我们在乌干达建立了长期和富有成效的合作基础。 加州大学旧金山分校（UCSF），为跨学科提供合适的环境 我们建议继续该计划，并将重点放在明年，并提出续约申请。 我们提出了一项为期一年的补充方案，以激发人们对研究的兴趣。 艾滋病毒和老龄化问题，并获得初步数据，为该领域未来的长期研究培训提供信息。 具体来说，我们的目标是： 1) 扩大 MakBSSR 培训计划，将艾滋病毒和艾滋病毒研究培训纳入其中 老龄化、年龄歧视和交叉耻辱，2）为硕士和研究生提供研究培训和指导 博士后奖学金学员应对乌干达不断变化的艾滋病毒和老龄化挑战，3) 准备 MakBSSR 研究培训计划的更新申请，重点关注艾滋病毒老龄化问题， 该补充材料将利用 MakBSSR 的现有资源。 计划包括 Mak 的社会、行为和生物医学科学家之间的合作， 艾滋病毒项目和美国的合作大学 在一年的补充期间，我们计划培训一名。 硕士学位研究生和两名博士后研究员，均在麦。

项目成果

Predictors of delayed Anti-Retroviral Therapy initiation among adults referred for HIV treatment in Uganda: a cross-sectional study.

乌干达接受艾滋病毒治疗的成年人延迟开始抗逆转录病毒治疗的预测因素：一项横断面研究。

• 发表时间: 2023-01-16
• 影响因子: 2.8
• 作者: Kiyingi, Micheal;Nankabirwa, Joaniter I;Sekaggya;Nangendo, Joan;Kiweewa, John M;Katahoire, Anne R;Semitala, Fred C
• 通讯作者: Semitala, Fred C

Acceptance of assisted partner notification among HIV-positive adults with severe mental illness at a national referral hospital in Uganda: a cross-sectional study.

乌干达国家转诊医院患有严重精神疾病的艾滋病毒阳性成人接受协助伴侣通知的情况：一项横断面研究。

• 发表时间: 2024-03-08
• 影响因子: 2.8
• 作者: Nante, Rachel Wangi;Muyinda, Herbert;Kiweewa, John M;Ndagire, Regina;Ssendikwanawa, Emmanuel;Ojiambo, Kevin Ouma;Nangendo, Joanita;Nakku, Juliet;Semitala, Fred C
• 通讯作者: Semitala, Fred C

Perspectives of female sex workers on HIV pre-exposure prophylaxis delivery in Uganda: A qualitative study.

乌干达女性性工作者对艾滋病毒暴露前预防的看法：一项定性研究。

• 发表时间: 2024-03-21
• 作者: Mpirirwe, Ruth;Mujugira, Andrew;Walusaga, Happy;Ayebare, Florence;Musanje, Khamisi;Ndugga, Patricia;Muhumuza, Christine;Nangendo, Joan;Semitala, Fred C;Kyambadde, Peter;Kalyango, Joan;Kiragga, Agnes;Karamagi, Charles;Kamya, Moses R;Armstrong
• 通讯作者: Armstrong

HIV viral load suppression among people with mental disorders at two urban HIV clinics in Uganda: a parallel convergent mixed methods study using the social ecological model.

乌干达两个城市艾滋病毒诊所的精神障碍患者的艾滋病毒病毒载量抑制：使用社会生态模型的平行收敛混合方法研究。

• 发表时间: 2023-09-19
• 作者: Ndagire, Regina;Wangi, Rachel Nante;Ojiambo, Kevin Ouma;Nangendo, Joanita;Nakku, Juliet;Muyinda, Herbert;Semitala, Fred C
• 通讯作者: Semitala, Fred C

Stigma mastery in people living with HIV: gender similarities and theory.

艾滋病毒感染者的耻辱掌握：性别相似性和理论。

• 发表时间: 2022-12
• 作者: Namisi, Charles Patrick;Munene, John C;Wanyenze, Rhoda K;Katahoire, Anne R;Parkes;Kentutsi, Stella;Nannyonga, Maria M;Ssentongo, Robina N;Ogola, Mabel K;Nabaggala, Maria Sarah;Amanya, Geofrey;Kiragga, Agnes N;Batamwita, R
• 通讯作者: Batamwita, R