Regional Oncology Research Center (American Eurasian Cancer Alliance Supplement)

区域肿瘤学研究中心（美国欧亚癌症联盟增刊）

• 批准号: 10923392
• 负责人: WILLIAM George NELSON
• 金额: $ 48.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10923392
• 关键词: Acceleration; American; Area; Armenia; Asian; Azerbaijan; Belarus; COVID-19 pandemic; Central Asia; Country; Development; Education; Estonia; Europe; European; Financial Hardship; Government; Health; Human Resources; Kazakhstan; Kyrgyzstan; Latvia; Lithuania; Malignant Neoplasms; Moldova; NCI-Designated Cancer Center; Oncology; Policies; Population; Prevention; Prevention strategy; Public Health; Research; Research Institute; Research Training; Resource Allocation; Resources; Scientist; Tajikistan; Training and Education; Translating; Ukraine; United States; Uzbekistan; Work; anticancer research; cancer prevention; catalyst; interest; programs; success; treatment strategy; virtual

Project Summary/Abstract The American Eurasian Cancer Alliance (AECA) was formed in 2001, originally called American Russian Cancer Alliance (ARCA), representing a unique partnership of scientists and clinicians from Russian Federation and the United States. Based on the successes of ARCA and growing interest from Eastern European and Central Asian countries, the scope and depth of the alliance expanded to the Eurasian region encompassing research, research training, research to policy, and health diplomacy activities. The program was re-branded under the American Eurasian Cancer Alliance (AECA) in 2014 to represent the wider range of national participation, which encompasses the following regions: Russian Federation, Central Asia (Kazakhstan, Uzbekistan, Kyrgyzstan, Tajikistan), Central Europe (Ukraine, Moldova, Belarus), Baltics (Lithuania, Latvia, Estonia), and Caucasus (Armenia, Georgia, Azerbaijan). The Alliance aims to pool intellectual and scientific resources to further research and discovery in cancer prevention and treatment strategies. AECA’s programs focus on three main areas: 1. Strengthening Global Cancer Research 2. Promoting Research Training and Education 3. Translating Research into Policy and Programs AECA has formed partnerships with several countries in Eurasia which were formalized through Memoranda of Understanding between Ministries of Health for cooperation in cancer research, prevention, and control. Through continued engagement with high-level stakeholders, AECA facilitates allocation of resources by Eurasian governments and cancer research institutes for the mutual benefit of U.S. and local populations. This engagement results in reduced financial burden to NCI-Designated Cancer Centers, and other U.S.-based institutes to establish and implement their research programs. During the COVID pandemic, AECA has continued its worked uninterrupted, albeit through virtual channels, by continuing to facilitate research, conducting education and public health initiatives. AECA works with NCI personnel in this effort.

项目概要/摘要 美国欧亚癌症联盟（AECA）成立于2001年，最初称为美国俄罗斯癌症联盟 联盟（ARCA），代表来自俄罗斯联邦和俄罗斯联邦的科学家和信徒的独特伙伴关系 基于 ARCA 的成功以及东欧和中亚日益增长的兴趣。 国家，联盟的范围和深度扩展到欧亚地区，包括研究、 研究培训、政策研究和卫生外交活动。 该计划于 2014 年在美国欧亚癌症联盟 (AECA) 下重新命名，以代表 更广泛的国家参与，包括以下地区：俄罗斯联邦、中部地区 亚洲（哈萨克斯坦、乌兹别克斯坦、吉尔吉斯斯坦、塔吉克斯坦）、中欧（乌克兰、摩尔多瓦、白俄罗斯）、波罗的海国家 （立陶宛、拉脱维亚、爱沙尼亚）和高加索地区（亚美尼亚、格鲁吉亚、阿塞拜疆）。 和科学资源，以进一步研究和发现 AECA 的癌症预防和治疗策略。 计划重点关注三个主要领域： 1. 加强全球癌症研究 2. 促进研究培训和教育 3. 将研究转化为政策和计划 AECA 已与欧亚大陆多个国家建立了合作伙伴关系，并通过以下备忘录正式确立： 卫生部之间就癌症研究、预防和控制方面的合作达成谅解。 通过与高层利益相关者的持续接触，AECA 促进了欧亚资源分配 政府和癌症研究机构为了美国和当地民众的共同利益。 参与减少了 NCI 指定癌症中心和其他美国癌症中心的财务负担 在新冠病毒大流行期间，AECA 继续开展研究项目。 尽管通过虚拟渠道，但其工作不间断，继续促进研究，开展 AECA 与 NCI 人员共同致力于这项工作。

项目成果

Added Value of Computer-aided CT Image Features for Early Lung Cancer Diagnosis with Small Pulmonary Nodules: A Matched Case-Control Study.

计算机辅助 CT 图像特征对小肺结节早期肺癌诊断的附加值：一项匹配的病例对照研究。

• DOI: 10.1148/radiol.2017162725
• 发表时间: 2024-09-14
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Peng Huang;Seyoun Park;Rongkai Yan;Junghoon Lee;L. Chu;C. Lin;Amira Hussien;J. Rathmell;Brett Thomas;Chen Chen;R. Hales;D. Ettinger;M. Brock;P. Hu;E. Fishman;E. Gabrielson;S. Lam
• 通讯作者: S. Lam

Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications.

前列腺癌表观遗传学：从基本机制到临床意义。

• DOI: 10.1101/cshperspect.a030445
• 发表时间: 2018-06-29
• 期刊: Cold Spring Harbor perspectives in medicine
• 作者: S. Yegnasubramanian;A. D. De Marzo;W. Nelson
• 通讯作者: W. Nelson

Mismatch repair-deficient prostate cancer with parenchymal brain metastases treated with immune checkpoint blockade.

采用免疫检查点阻断治疗的错配修复缺陷型前列腺癌伴实质脑转移。

• 发表时间: 2021
• 影响因子: 1.8
• 作者: Sena, Laura A;Salles, Daniela C;Engle, Elizabeth L;Zhu, Qingfeng;Tukachinsky, Hanna;Lotan, Tamara L;Antonarakis, Emmanuel S
• 通讯作者: Antonarakis, Emmanuel S

Longitudinal measurement of subcutaneous and intratibial human prostate cancer xenograft growth and response to ionizing radiation by plasma Alu and LINE-1 ctDNA: A comparison to standard methods.

通过血浆 Alu 和 LINE-1 ctDNA 纵向测量皮下和胫骨内人前列腺癌异种移植物的生长和对电离辐射的反应：与标准方法的比较。

• 发表时间: 2021
• 作者: Mishra, Alok;Zennami, Kenji;Velarde, Esteban;Thorek, Daniel L J;Yegnasubramanian, Srinivasan;DeWeese, Theodore L;Lupold, Shawn E
• 通讯作者: Lupold, Shawn E

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer.

非肿瘤前体中的致癌基因融合作为细菌感染可引发前列腺癌的证据。

• 发表时间: 2021
• 影响因子: 11.1
• 作者: Shrestha, Eva;Coulter, Jonathan B;Guzman, William;Ozbek, Busra;Hess, Megan M;Mummert, Luke;Ernst, Sarah E;Maynard, Janielle P;Meeker, Alan K;Heaphy, Christopher M;Haffner, Michael C;De Marzo, Angelo M;Sfanos, Karen S
• 通讯作者: Sfanos, Karen S