Multiethnic Study of Breast Arterial Calcium Gradation and CVD

乳腺动脉钙分级和 CVD 的多种族研究

基本信息

批准号：
8461688
负责人：
Carlos Iribarren
金额：
$ 136.59万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-12 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8461688
关键词：
Advisory Committees African American Age Alcohol consumption Anger Ankle Asians Atherosclerosis Body mass index Brain hemorrhage Breast Breast Cancer Early Detection Breast Feeding C-reactive protein Calcium California Cardiovascular Diseases Cardiovascular system Caucasians Caucasoid Race Cause of Death Cerebrovascular Disorders Classification Clinical Clinical Practice Guideline Coronary heart disease Data Densitometry Detection Diabetes Mellitus Diet Ethnic Origin Event Family history of Female Future Glomerular Filtration Rate Heart Diseases Heart failure High Density Lipoprotein Cholesterol High Prevalence Hispanics Hormones Hostility Household Hyperlipidemia Hypertension Incidental Findings Income Insulin Resistance Ischemic Stroke Latina Malignant Neoplasms Mammography Measures Medical center Menopause Metabolism Methods Minerals Nitrogen Obstructive Sleep Apnea Parathyroid gland Participant Peripheral Vascular Diseases Pharmaceutical Preparations Phosphorus Physical activity Preventive Prospective Studies Psychosocial Factor Race Recording of previous events Recruitment Activity Reliance Renal function Reproductive Health Research Risk Risk Factors Role Serum Services Severities Sleep Smoking Social support Stratification Testing Therapeutic Intervention Time Transient Ischemic Attack Variant Vitamin D Woman aged base bisphosphonate calcification cardiovascular disorder risk cardiovascular risk factor cohort coronary artery calcification depressive symptoms digital hormone therapy improved indexing insight malignant breast neoplasm milligram novel parity population based screening tool vascular bed waist circumference

项目摘要

DESCRIPTION (provided by applicant): Currently, mammographically-detected breast arterial calcifications (BAC) are considered an incidental finding without clinical importance since they are not associated with increased risk of breast cancer. However, presence of BAC on mammography correlates with several (but not all) traditional cardiovascular disease (CVD) risk factors and with prevalent and incident CVD. Thus, BAC detected during routine mammography is a noteworthy finding that could be valuable in identifying asymptomatic women at increased future CVD risk that may be candidates for more aggressive management. In addition, there are notable differences in measures of subclinical atherosclerosis burden in women (i.e., coronary artery calcification) by race/ethnic background, and the same appears to be true for BAC, although data are very limited. Another noteworthy limitation of prior research on BAC is the reliance on absence vs. presence of BAC; no study to date has determined gradation of BAC. The 3 specific aims are: 1) To establish a multi- ethnic cohort (n=5,400) between the ages of 60 and 79 years with equal representation of white (n=1,350; 25%), African-American (n=1,350; 25%), Asian (n=1,350; 25%) and Hispanic/Latina (n=1,350; 25%) women. All participants will be recruited at the time of their regular screening mammography (over a 2 year period) at three Kaiser Permanente of Northern California medical centers and will be free of clinical CVD at baseline. A new, validated densitometry method will be used to estimate BAC mass (in milligrams) using digital mammograms; 2) To document race/ethnic variation in BAC mass and to examine associations of BAC mass with sociodemographic background, family history of CVD, traditional and novel CVD risk factors, reproductive health factors, psychosocial factors, selected mineral metabolism factors, selected medication use (statins and nitrogen-containing bisphosphonates), breast size and sleep-related factors; and 3) To elucidate the role of BAC mass in the prediction of coronary heart disease (CHD), cerebrovascular disease, heart failure, peripheral vascular disease and total CVD and to determine whether adding BAC mass to predictionmodels based on traditional risk factors improves classification of risk for total CVD and its components. Accomplishing these aims will provide novel insights into the utility of BAC mass as a screening tool to assess CVD risk.

描述（由申请人提供）：目前，乳腺X线检查乳腺动脉钙化（BAC）被认为是偶然发现而没有临床重要性，因为它们与乳腺癌风险增加无关。然而，乳房X线摄影的存在与几种（但不是全部）传统心血管疾病（CVD）危险因素以及普遍和入射CVD相关。因此，在常规乳房X线摄影期间检测到的BAC是一个值得注意的发现，对于确定未来CVD风险的无症状女性可能是有价值的，这可能是对更具侵略性管理的候选者的候选者。此外，通过种族/族裔背景，女性（即冠状动脉钙化）的亚临床动脉粥样硬化负担的度量存在明显差异，尽管数据非常有限，但对于BAC来说似乎是如此。对BAC的先前研究的另一个值得注意的局限性是依赖缺乏与BAC的存在。迄今为止，尚无研究确定BAC的分级。 3个具体目的是：1）在60至79岁之间建立一个多民族队列（n = 5,400），白色（n = 1,350; 25％），非裔美国人（n = 1,350; 25％），亚洲人，亚洲（n = 1,350; 25％; 25％）和女性/latina and latina（n = 1,350; 25％）和女性latina（n = 1,350; 25％）（n = 1,350; 25％）（n = 1,350; 25％）（n = 1,350; 25％）（n = 1,350; 25％）（n = 1,350;所有参与者将在北加州医疗中心的三个Kaiser Permanente进行定期筛查乳房X线摄影（在2年内）进行定期筛查时招募，并在基线时没有临床CVD。一种新的，经过验证的光密度测定法将用于使用数字乳房X线照片估计BAC质量（以毫克为单位）。 2）记录BAC质量的种族/种族变异，并检查BAC质量与社会人口统计学背景，CVD家族史，传统和新颖的CVD风险因素，生殖健康因素，心理社会因素，选定的矿物质代谢因素，选定的药物使用（Statins和硝基含量为Bisphopphopphonates），乳腺肥大和睡眠因素和睡眠因素； 3）为了阐明BAC质量在冠心病预测（CHD），脑力血管疾病，心力衰竭，周围血管疾病和总CVD中的作用，并确定基于传统风险因素将BAC质量添加到预测模型中是否可以改善CVD总风险分类及其组件的分类。实现这些目标将为BAC质量作为评估CVD风险的筛查工具提供新的见解。