Cardiac and Renal Disease Study (CARDS)

心脏和肾脏疾病研究 (CARDS)

• 批准号: 6651095
• 负责人: Carlos Iribarren
• 金额: $ 12.63万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651095
• 关键词: cardiovascular disorder epidemiology; cardiovascular disorder risk; chronic renal failure; clinical research; comorbidity; disease /disorder etiology; epidemiology; human data; hypertension; kidney function; longitudinal human study; patient oriented research

DESCRIPTION (provided by applicant): Mild-to-moderate chronic renal insufficiency (CRI) is reaching epidemic proportions in the US. Studies relating mild-to-moderate CRI and cardiovascular risk are limited and inconsistent. Although we have learned much about the natural history and adverse outcomes associated with end-stage renal disease (ESRD), we have little specific information regarding risk factors for the development or progression of renal disease. Using a population-based, ethnically diverse large cohort of male and female health plan enrollees with extended follow-up, we propose: Aim 1: To evaluate: a) whether baseline and decline in renal function overtime are independent predictors of coronary heart disease (CHID), stroke, heart failure and peripheral vascular disease; b) effect modifiers of these relationships, including baseline hypertension and diabetes status. Aim 2: To determine whether baseline and increase over time in blood pressure level (as well as prevalent and incident hypertension) are predictive of the subsequent risk of ESRD after adjusting for diabetes and for baseline serum creatinine, proteinuria and hematuria. Aim 3: To examine other potential predictors of ESRD including demographic factors (race/ethnicity, level of education) total cholesterol level, family history of renal disease, body mass index, sagittal abdominal diameter, cigarette (as well as cigar and pipe) smoking, coffee intake, alcohol consumption, family history of renal disease and self-reported occupational exposures. We will take advantage of existing longitudinal data resources at the Northern California Kaiser Permanente Division of Research and available patient-level cross-linkage with the US Renal Data System end-stage renal disease registry to obtain comprehensive renal and cardiovascular outcomes. A de novo prospective study of this magnitude and duration will be prohibitively expensive and time-consuming. This proposal will leverage unique resources and methodological expertise to provide novel insights into the epidemiology of renal disease and its association with cardiovascular events.

描述（由申请人提供）： 轻度至中度慢性肾功能不全（CRI）正在流行 美国的比例。与轻度至中度CRI有关的研究和 心血管风险有限且不一致。虽然我们学会了 关于自然历史和与终点阶段相关的不利结果的很多 肾脏疾病（ESRD），我们几乎没有有关风险的具体信息 肾脏疾病发展或进展的因素。 使用基于人群的种族多样化的男性和女性队列 我们建议：目标1：评估： a）基准和肾功能的加班是否独立 冠心病（CHID），中风，心力衰竭和 周围血管疾病； b）这些关系的效果修饰符， 包括基线高血压和糖尿病状况。目标2：确定 基线和随着时间的流逝是否在血压水平上增加（以及 普遍和入射高血压）可预测随后的风险 调整糖尿病和基线血清肌酐后ESRD， 蛋白尿和血尿。目标3：检查其他潜在预测因素 ESRD包括人口因素（种族/种族，教育水平）总计 胆固醇水平，肾脏疾病家族史，体重指数，矢状 腹直径，香烟（以及雪茄和管道）吸烟，咖啡 摄入量，饮酒，肾脏疾病的家族史和自我报告 职业暴露。 我们将利用北部现有的纵向数据资源 加利福尼亚凯撒（Kaiser）长期研究部和可用的患者级别 与美国肾脏数据系统终末期肾脏疾病登记处的交联 获得全面的肾脏和心血管效果。从头开始 对这种规模和持续时间的前瞻性研究将被禁止 昂贵且耗时。该建议将利用独特的资源 和方法论专业知识，以提供有关流行病学的新颖见解 肾脏疾病及其与心血管事件的关联。