NEUROENDOCRINE CONTROL OF BEHAVIORAL ONTOGENY

行为个体发育的神经内分泌控制

基本信息

批准号：
2546307
负责人：
ROSEMARY KNAPP
金额：
$ 2.09万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-10-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2546307
关键词：
aminoacid analog androgen receptor animal communication behavior animal developmental psychology behavioral /social science research tag fish gender difference neuroendocrine system receptor expression

项目摘要

Steroid hormones are known to have important effects on behavioral and morphological characters that differ between the sexes. Many sexual dimorphisms are often first expressed coincident with increases in circulating androgens seen at male sexual maturity, as is the case for deepening of the voice in human males. In some species, however, some sexually mature males regularly fail to express male-typical morphology or behavior. Species with such clear intra-sexual dimorphisms in addition to the more typical inter-sexual dimorphisms present ideal model systems for examining neuroendocrine mechanisms underlying both l) normal development of sexually dimorphic characters and 2) uncoupling of male sexual maturation and the expression of male-typical characters. The fish, Porichthys notatus, is ideally suited for such studies because there are distinct inter- and intra- sexual dimorphisms of its simple vocal system. This proposal aims to determine l) the normal development of the vocal system in juveniles, and 2) females and the two types of males differ in circulating levels of particular steroid hormones during development or if system components are differentially sensitive to circulating androgens as a result of differences in androgen receptor expression. The existence of reproductively mature and competent males that are feminized/demasculinized with respect to both neural and muscular components of the vocal system provides an ideal opportunity to broaden our understanding of how the expression of sexual dimorphisms can be uncoupled from sexual maturation in species, including humans, where intra-sexual variation is more continuous.

众所周知，类固醇激素对行为和行为有重要影响。两性之间存在差异的形态特征。许多性二态性通常首先表达与增加男性性成熟时出现的循环雄激素，就像人类男性的声音变得低沉。然而，在某些物种中，有些性成熟的男性通常无法表达男性典型特征形态或行为。具有如此明显性内性的物种除了更典型的两性二态性之外的二态性提出用于检查神经内分泌机制的理想模型系统 l) 两性二态性特征的正常发育 2）男性性成熟与表达的脱钩男性典型人物。这种鱼 Porichthys notatus 是理想的选择适合此类研究，因为存在不同的内部和内部其简单发声系统的性别二态性。该提案旨在确定l) 青少年发声系统的正常发育， 2) 女性和两类男性的循环水平不同发育过程中或系统中的特定类固醇激素成分对循环雄激素的敏感性不同雄激素受体表达差异的结果。存在生殖成熟且有能力的雄性在神经和肌肉方面女性化/去男性化声音系统的组成部分提供了理想的机会拓宽我们对性别二态性如何表达的理解可以与包括人类在内的物种的性成熟脱钩，其中性内变异更加连续。