Molecular Analysis and Statistical Support Facility Core (MASS)

分子分析和统计支持设施核心 (MASS)

• 批准号: 10592346
• 负责人: Kun Lu
• 金额: $ 31.21万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592346
• 关键词: Address; Applications Grants; Area; Award; Bioinformatics; Biometry; Clinical; Collaborations; Communities; Competence; Conceptions; Core Facility; Data; Data Analyses; Data Analytics; Data Collection; Data Science; Education and Outreach; Educational workshop; Ensure; Environmental Health; Faculty; Genomics; Grant; Health Sciences; Human Resources; Human Subject Research; Infrastructure; Interdisciplinary Study; Investigation; Laboratories; Lead; Medicine; Methods; Molecular; Molecular Analysis; Neurodevelopmental Disorder; North Carolina; Pathology; Pilot Projects; Predisposition; Public Health; Pulmonary Heart Disease; Qualifying; Research; Research Design; Research Personnel; Sample Size; Science; Services; Statistical Methods; Technology; Training; Translating; Translational Research; Translations; Update; Work; analytical method; community engagement; data acquisition; data analysis pipeline; developmental disease; educational atmosphere; environment related cancer; improved; innovation; instrumentation; lectures; member; method development; novel; outreach; population based; programs; symposium; user-friendly

ABSTRACT The Molecular Analysis and Statistical Support (MASS) core supports the theme of the UNC Center for Environmental Health and Susceptibility (CEHS), translating interdisciplinary research on environmental health susceptibility to improve public health in North Carolina. The MASS will provide comprehensive, user-friendly, and efficient support for data acquisition, analysis, and interpretation needs of laboratory, clinical, and population-based investigations in environmental health. The MASS will provide access and facilitate utilization of a range of molecular cores and will integrate this support with rigorous and state-of-the-art biostatistics and bioinformatics assistance in study design, data acquisition, and data analysis to support translational research in the areas of Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease (Aim 1). The MASS will develop and implement new molecular and statistical methods to meet investigators' analytic needs and to adapt to emerging data analysis strategies and unique data problems (Aim 2). The MASS will provide technical training, ranging from molecular methods to statistical, bioinformatics, and data science, for junior investigators through seminars, workshops, and symposia tailored to the needs of CEHS researchers (Aim 3). We collaborate with campus-wide efforts in genomics, exposure science, data science and computational medicine to expand the influence and expertise of CEHS investigators and junior investigators. Finally, the MASS subcores function collaboratively with the Integrated Health Sciences Facility Core (IHSFC) to support existing research, novel pilot projects, community engagement, and grant applications (Aim 4). Major program efforts and accomplishments during the past grant cycle include: updated infrastructure and instrumentation to enable CEHS investigators to access state-of-the-art analytical and molecular technologies; a new Method Development Award Program to support developing innovative new exposure science and molecular methods for CEHS investigators; and novel state-of-the-art data analysis pipelines for CEHS members. Faculty with expertise in molecular and quantitative methods development are available and serve as collaborators on pilot projects and external grants. Our MASS facility core provides a scalable, high quality, full service core facility to address data acquisition and analytic needs of our membership, from inception to implementation.

抽象的 分子分析和统计支持 (MASS) 核心支持北卡罗来纳大学中心的主题 环境健康与敏感性（CEHS），将环境的跨学科研究转化为 健康易感性，以改善北卡罗来纳州的公共卫生。 MASS 将提供全面的、 用户友好且高效的支持实验室、临床、实验室的数据采集、分析和解释需求 以及基于人群的环境健康调查。 MASS 将提供访问并提供便利 利用一系列分子核心，并将这种支持与严格和最先进的技术相结合 生物统计学和生物信息学协助研究设计、数据采集和数据分析，以支持 环境癌症、心肺疾病和发育领域的转化研究 疾病（目标 1）。 MASS 将开发和实施新的分子和统计方法，以满足 研究人员的分析需求并适应新兴的数据分析策略和独特的数据问题（目标 2）。 MASS 将提供从分子方法到统计学、生物信息学和 数据科学，通过针对 CEHS 需求量身定制的研讨会、讲习班和座谈会为初级研究人员提供 研究人员（目标 3）。我们与全校范围内基因组学、暴露科学、数据科学和 计算医学扩大 CEHS 研究人员和初级研究人员的影响力和专业知识。 最后，MASS 子核心与综合健康科学设施核心 (IHSFC) 协同运作 支持现有研究、新颖的试点项目、社区参与和拨款申请（目标 4）。主要的 上一个赠款周期的方案努力和成就包括：更新的基础设施和 使 CEHS 研究人员能够获得最先进的分析和分子技术的仪器； 一个新的方法开发奖励计划，以支持开发创新的新曝光科学和 CEHS 研究人员的分子方法；以及用于 CEHS 的新颖、最先进的数据分析管道 成员。具有分子和定量方法开发专业知识的教师可以作为 试点项目和外部赠款的合作者。我们的 MASS 设施核心提供可扩展、高质量、全面的 服务核心设施，从成立到满足我们会员的数据采集和分析需求 执行。