Understanding the neurodevelopmental effects of youth tackle football participation

了解青少年参与橄榄球运动对神经发育的影响

• 批准号: 10742262
• 负责人: Jaclyn B. Caccese
• 金额: $ 65.27万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10742262
• 关键词: Adult; Age; Attenuated; Behavior; Benefits and Risks; Brain; Brain Injuries; Child; Childhood; Chronic Brain Injury; Clinical; Cognition; Collaborations; Communities; Community Outreach; Costs and Benefits; Critical Illness; Data; Decision Making; Development; Early Diagnosis; Enrollment; Equilibrium; Etiology; Exhibits; Exposure to; Funding; Future; Goals; Health; Impaired cognition; Impairment; Intervention; Knowledge; Long-Term Effects; Manufactured football; Measures; Mission; National Institute of Child Health and Human Development; Nature; Neck; Nervous System Trauma; Neurodegenerative Disorders; Neurodevelopmental Disorder; Ohio; Outcome; Parents; Patients; Performance; Pilot Projects; Play; Policies; Policy Maker; Prevention; Productivity; Public Health; Reaction Time; Recording of previous events; Reporting; Research; Rest; Risk; Risk Factors; Risk Reduction; Seasons; Short-Term Memory; Sports; Structure; Testing; Time; Visual; Work; Youth; adverse childhood events; attentional control; cognitive function; cognitive testing; college; community engagement; contact sports; critical period; executive function; functional disability; head impact; high school; improved; instrument; modifiable risk; multidisciplinary; myelination; neural; neurodevelopment; neurodevelopmental effect; neuroimaging; neuromuscular; neurophysiology; pediatric trauma; prevent; programs; white matter; youth sports

ABSTRACT Potential long-term effects of tackle football and other contact sports have created significant public health concerns about the risk of childhood participation. Considering the retrospective and cross-sectional nature of prior work, there are critical knowledge gaps regarding the causality of youth tackle football participation and subsequent clinical outcomes that preclude decision-making at the patient and policy level. Further, modifiable risk factors (e.g., neuromuscular control) may influence exposure to and thus, outcomes from football-related neurotrauma, but prevention remains understudied. Here we overcome some of the previous barriers to progress in this field by acquiring a “true baseline” for athletes before they begin their first season of tackle football and following them longitudinally across the first year of participation. We received funding from Ohio State’s Chronic Brain Injury Program and successfully collected pilot data on 50 youth tackle football players (ages 8-12 years); these data form the basis of our current proposal. Aim 1 will identify risk factors for higher exposure to football- related neurotrauma. We will measure football-related neurotrauma exposure in first-year youth tackle football players during all practices and games using instrumented mouthguards. We will use handheld dynamometry to measure neck strength and will measure neuromuscular control through visual, vestibular, and reaction time testing. Aim 2 will determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football exposure. We will enroll children who are registered for, but have not yet begun participating in youth tackle football, as well as children registered for non-contact sports and children not playing any sports. Aim 2a will determine short-term changes in cognitive function and brain structure and function caused by football-related neurotrauma exposure from pre-season to post-season. Aim 2b will determine longer-term changes across the first year of participation by examining players during the off-season just prior to the start of the next season. Aim 2c will determine what factors (e.g., football-related neurotrauma exposure, exposure to adverse childhood events, pre-existing neurodevelopmental disorders) contribute to differences from typical development. We hypothesize that youth tackle football exposes children to repetitive neurotrauma during a period of rapid neurodevelopment, resulting in observable cognitive impairments and structural and functional changes in the brain, most likely in attentional control networks. Our proposal combines a state-of-the-art approach to determining the effects of football-related neurotrauma on neurodevelopment, a productive collaboration with youth sports programs in Ohio, community engagement and outreach, and a multidisciplinary team of experts. The societal and clinical impact of these findings cannot be overstated. In quantifying football-related neurotrauma exposure (Aim 1) and its effects on neurodevelopment (Aim 2) across the first year of youth tackle football participation, our expected outcomes will inform community stakeholders and policy-makers in their appraisal of the cost and benefit of children participating in youth tackle football.

抽象的 足球和其他接触性运动的潜在长期铲球效应已对公众健康产生了重大影响 考虑到儿童参与的风险的回顾性和横截面性质。 在之前的工作中，关于青少年铲球参与的因果关系存在严重的知识差距， 随后的临床结果妨碍了患者和政策层面的决策。此外，可以修改。 风险因素（例如神经肌肉控制）可能会影响与足球相关的接触，从而影响其结果 神经创伤，但预防措施仍未得到充分研究。在这里，我们克服了之前的一些进展障碍。 在这个领域，通过为运动员在开始他们的第一个铲球赛季之前获得“真正的基线”， 我们在参与的第一年纵向跟踪他们，并获得了俄亥俄州立大学慢性病学的资助。 脑损伤计划并成功收集了 50 名青少年铲球足球运动员（8-12 岁）的试点数据； 这些数据构成了我们当前提案的基础，目标 1 将确定更多接触足球的风险因素。 我们将测量一年级青少年足球中与足球相关的神经创伤暴露情况。 球员在所有练习和比赛中都使用仪器护齿套，我们将使用手持测力仪来测量。 测量颈部力量，并通过视觉、前庭和反应时间测量神经肌肉控制 目标 2 将确定与足球相关的神经创伤暴露对神经发育的影响。 以前没有接触过橄榄球的孩子 我们将招收已注册但尚未参加过橄榄球比赛的孩子。 尚未开始参加青少年橄榄球比赛的儿童，以及注册参加非接触性运动的儿童和儿童 不参加任何运动将决定认知功能和大脑结构的短期变化 Aim 2b 将影响从季前到季后因足球相关的神经创伤而导致的功能。 通过在休赛期检查球员来确定参与第一年的长期变化 Aim 2c 将在下赛季开始之前确定哪些因素（例如与足球相关的神经创伤）。 接触、不良童年事件、先前存在的神经发育障碍）会导致 与典型发展的不同之处在于，青少年足球铲球让孩子们面临重复性的环境。 神经快速发育期间的神经创伤，导致明显的认知障碍和 大脑的结构和功能变化，最有可能是在注意力控制网络中。 确定足球相关神经创伤对神经发育影响的最先进方法， 与俄亥俄州青少年体育项目、社区参与和外展以及 这些研究结果的社会和临床影响不容小觑。 量化足球相关的神经创伤暴露（目标 1）及其对神经发育的影响（目标 2） 青少年参与橄榄球运动的第一年，我们的预期成果将告知社区利益相关者 和政策制定者评估儿童参加青少年橄榄球运动的成本和收益。