Data Management and Statistical Core

数据管理与统计核心

基本信息

批准号：
10620675
负责人：
Sudeshna Das
金额：
$ 34.63万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10620675
关键词：
Acceleration Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Archives Basic Science Biological Markers Clinic Clinical Clinical Data Clinical Research Clinical Trials Clinical Trials Design Collaborations Communication Communities Community Outreach Computer software Consultations Data Data Analyses Data Set Databases Development Disease Early identification Education Electronic Health Record Engineering Ensure Epidemiology Future Genotype Goals Heterogeneity Image Impaired cognition Individual Informatics Infrastructure Link Massachusetts Measures Memory Methodology Methods Participant Publications Reporting Reproducibility Research Research Design Research Personnel Research Project Grants Resource Informatics Resources Sampling Biases Science Scientist Secure Selection Bias Source Source Code Standardization Statistical Methods Statistical Models Subjects Selections System Terminology Training Translational Research Underrepresented Minority Videotape Visualization software Vocabulary analytical method biobank bioinformatics resource clinical database cohort data exchange data integration data management data quality design education research electronic health database flexibility improved informatics tool innovation interoperability investigator training novel open source query tools rare condition research study statistical learning statistics symposium tool translational scientist web site

项目摘要

Massachusetts Alzheimer’s Disease Research Center: Data Core The Data Management and Statistics Core (Data Core) of the Massachusetts Alzheimer’s Disease Research Center (MADRC) provides state-of-the-art data management and statistical expertise for the MADRC and affiliated research studies, for collaborative efforts with other ADRCs, and for national AD/ADRD research initiatives. The Data Core is an essential component of the MADRC research enterprise as it facilitates scientific rigor, regulatory-compliance and strong connectedness across cores within our Center, and with NACC and others outside our Center. It serves to minimize the burdens of research by optimizing study efficiencies through subject selection, endpoint selection, facile and adaptive designs, as well as provides guidance on rigorous study design and analyses. The Data Core provides informatics expertise and assistance, including data-management, timely data transmission to NACC, and query and reporting support to all the MADRC Cores. We will contribute to MADRC’s goal of understanding heterogeneity through formal statistical modeling and use of latent variables, through statistical learning approaches that accommodate longitudinal and survival data under biased sampling and through analysis of omics data. We will contribute to MADRC’s goal of accelerating toward a cure by developing, importing and disseminating innovative statistical methods and informatics tools that will optimize resources. The Core aims to marshal resources (Aims 1,2) to support clinical, translational, and basic research in AD/ADRD by contributing statistical and informatics expertise to interdisciplinary teams. The Core aims to develop new strategies (Aims 3,4) to provide practical and efficient study designs and unbiased analytic methods, and to implement innovative informatics resources. The Core aims to build the future (Aims 5,6) by collaborating with the Research Education Component (REC) to train clinical and translational researchers in quantitative methods and to attract quantitative scientists to AD/ADRD research. The Data Core provides guidance on scientific rigor: it assists MADRC researchers with study design and ensures valid and accurate analyses of studies across all MADRC Cores. The Data Core also advises MADRC researchers on data quality, version control and tracking measures. It ensures all systems are secure and within the Partners IT Infrastructure. The Core promotes open and reproducible science by disseminating methodological innovations to the scientific community and through data and software sharing.

马萨诸塞州阿尔茨海默病研究中心：数据核心马萨诸塞州阿尔茨海默病研究的数据管理和统计核心（数据核心）中心 (MADRC) 为 MADRC 和附属研究，与其他 ADRC 合作以及国家 AD/ADRD 研究数据核心是 MADRC 研究事业的重要组成部分，因为它促进了研究工作的开展。科学严谨、合规性以及我们中心各核心之间的紧密联系，并与 NACC 和我们中心之外的其他机构通过优化研究来最大限度地减少研究负担。通过主题选择、端点选择、简便和适应性设计来提高效率，并提供严格的研究设计和分析的指导提供信息学专业知识和协助，包括数据管理、向 NACC 及时传输数据以及向 NACC 提供查询和报告支持所有 MADRC 核心。我们将通过正式的统计模型为 MADRC 理解异质性的目标做出贡献通过适应纵向和生存数据的统计学习方法使用潜在变量我们将为 MADRC 的目标做出贡献。通过开发、引进和传播创新的统计方法和将优化资源的信息学工具。核心旨在整合资源（目标 1,2）以支持。通过贡献统计和信息学专业知识，开展 AD/ADRD 的临床、转化和基础研究核心旨在制定新的战略（目标 3,4），以提供实用和高效的服务。研究设计和公正的分析方法，并实施创新的信息学资源。旨在通过与研究教育部分 (REC) 合作来培养未来（目标 5,6）定量方法的临床和转化研究人员，并吸引定量科学家研究 AD/ADRD 研究。数据核心为科学研究提供指导：它协助 MADRC 研究人员进行研究设计和确保对所有 MADRC 核心的研究进行有效和准确的分析。数据核心还为 MADRC 提供建议。研究人员负责数据质量、版本控制和跟踪措施，确保所有系统的安全和安全。在合作伙伴 IT 基础设施内，核心通过传播促进开放和可复制的科学。通过数据和软件共享向科学界提供方法创新。