Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)

Kids First 数据资源中心 (KFDRC)：代表共同基金数据生态系统 (CFDE) 的未来，利用当前数据驱动的机会

• 批准号: 10907061
• 负责人: Jack DiGiovanna
• 金额: $ 259.35万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2024-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10907061
• 关键词: Annual Reports; Area; Bioinformatics; Child; Childhood Brain Neoplasm; Collaborations; Communication; Computer software; Data; Data Coordinating Center; Development; Ensure; Ethics; Funding; Future; Genomics; Genotype-Tissue Expression Project; Goals; Human Resources; Infrastructure; Modification; Neurosciences Research; Pediatric Hospitals; Persons; Philadelphia; Policies; Progress Reports; Publications; Reproducibility; Research; Research Personnel; Scientist; Teleconferences; United States National Institutes of Health; Visualization; Work; anticancer research; cloud based; computer science; data ecosystem; data resource; data sharing; interoperability; large scale data; programs; response; software development; tool; working group

Rationale for Multiple PI Proposal This proposal focuses on activities and collaborations with an initial set of Common Fund DCCs and the CFDE-CC in response to the Engagement Opportunity “Engaging Common Fund Data Coordinating Centers to Establish the Common Fund Data Ecosystem (CFDE)” OTA-20-2005. Our proposed engagements span the 3 key areas defined in the OT EOA and include GTEx, LINCS, HUBMAP, and SPARC as well as the activities the Kids First DRC is leading as part of the NIH Interoperability Working Group to further the establishment of the Common Fund Data Ecosystem (CFDE). The four investigators collaborating on this proposal have distinct professional backgrounds, areas of expertise, and research tools at their disposal including leading the Kids First DCC/DRP and CAVATICA efforts. At the Children’s Hospital of Philadelphia, Dr. Adam Resnick is a cancer and neuroscience research scientist with expertise in pediatric brain tumors and Dr. Allison Heath is a computer science expert in large-scale data bioinformatics and compute infrastructure. These experts will work together to lead the CHOP project team. At Centre Hospitalier Universitaire Sainte-Justine, Dr. Vincent Ferretti develops bioinformatics software for both large-scale software development and computational genomics. At Seven Bridges, Dr. Jack DiGiovanna is an expert in cloud-based analysis platforms for bioinformatics that are scalable, collaborative, and reproducible. Responsibilities of Investigators All PIs will share responsibility for ensuring the ethical conduct of the project, upholding the scientific integrity of the project, administration, oversight and coordination of the project’s management. Dr. Adam Resnick will serve as the contact PI. He will be responsible for the overall strategy, determining the prioritization of scientific use cases, and ensuring that the project meets its goals of scientific impact. Dr. Heath will oversee and facilitate the completion of the technical milestones and deliverables across all CDFE engagements. Dr. Heath will also be responsible for the execution of interoperability strategies with CFDE and the NIH IC Stacks. Dr. Ferretti will supervise the KFDRC portal development team and will be responsible for all of their relevant deliverables, such as authentication with NIH RAS and visualization integrations with LINCS. Dr. DiGiovanna will supervise the CAVATICA development team and will be responsible for all of their relevant deliverables, such as GA4GH DRS integration and multi-cloud capabilities. Communication and Data Sharing The PIs will communicate weekly and hold monthly teleconferences with PIs at the other organizations to discuss the CFDE and all administrative responsibilities. In addition, PIs will meet in person with all personnel at least annually to assess progress and make major decisions about the direction of the program. If changes are warranted, PIs will work together to discuss those modifications and the redistribution of funds, if necessary. A publication policy will be established based on the relative scientific contributions of the PIs and key personnel. Dr. Resnick will serve as contact PI and be responsible for submission of progress reports, annual reports to the NIH and all other communication.

多项 PI 提案的理由 该提案重点关注与首批共同基金 DCC 和 CFDE-CC 回应参与机会“参与共同基金数据协调” 建立共同基金数据生态系统 (CFDE) 的中心” OTA-20-2005。 业务涵盖 OT EOA 中定义的 3 个关键领域，包括 GTEx、LINCS、HUBMAP 和 SPARC 以及 Kids First DRC 作为 NIH 互操作性工作一部分所领导的活动 集团进一步建立共同基金数据生态系统（CFDE）。 合作完成该提案的四位研究人员具有不同的专业背景、领域 他们可以使用专业知识和研究工具，包括领导 Kids First DCC/DRP 和 CAVATICA 努力。 Adam Resnick 博士在费城儿童医院从事癌症和神经科学研究 Allison Heath 博士是一位在儿科脑肿瘤方面拥有专业知识的科学家，也是一位计算机科学专家 这些专家将共同领导大规模数据生物信息学和计算基础设施。 圣贾斯汀大学中心医院的 CHOP 项目团队由 Vincent Ferretti 博士开发 用于大规模软件开发和计算基因组学的生物信息学软件。 Bridges，Jack DiGiovanna 博士是基于云的生物信息学分析平台的专家， 可扩展、协作且可复制。 调查员的职责 所有 PI 将共同承担确保项目道德行为、维护科学依据的责任 项目的完整性、项目管理的管理、监督和协调。 Adam Resnick 博士将担任联络 PI，负责总体策略、确定。 科学用例的优先顺序，并确保项目实现其科学影响的目标。 希思博士将监督并促进所有技术里程碑和可交付成果的完成 Heath 博士还将负责与 CDFE 的互操作性策略的执行。 CFDE 和 NIH IC Stacks 博士将监督 KFDRC 门户开发团队，并将成为 负责所有相关的交付成果，例如 NIH RAS 的身份验证和可视化 DiGiovanna 博士将监督 CAVATICA 开发团队，并将与 LINCS 进行整合。 负责所有相关的可交付成果，例如 GA4GH DRS 集成和多云 能力。 通讯与数据共享 PI 将与其他组织的 PI 每周进行沟通并每月举行电话会议，以 此外，PI 将与所有人会面。 人员至少每年评估进展情况并就项目方向做出重大决策 如果需要更改，PI 将共同讨论这些修改和计划。 如有必要，将根据相关科学性制定出版政策。 PI 和关键人员的贡献 Resnick 博士将担任联系人 PI 并负责 向 NIH 提交进度报告、年度报告以及所有其他通讯。