IDIQ BASE BIOMEDICAL ASSAY LABORATORY FOR THE DIVISION OF POPULATION HEALTH RESEARCH - PROJECT TRACKING AND CONSULTATION

IDIQ 人口健康研究部生物医学检测实验室 - 项目跟踪和咨询

• 批准号: 10905961
• 负责人: MICHAEL TSAI
• 金额: $ 2.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2029-09-11
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10905961
• 关键词: Adipose tissue; Adolescent; Adult; Antioxidants; Behavior; Biocompatible Materials; Biological; Biological Assay; Biological Markers; Blood; C-reactive protein; Caring; Carotenoids; Child Development; Child Health; Clinical; Clip; Collection; Concentration measurement; Conceptions; Consultations; Contractor; Contracts; DNA; Data; Development; Enzyme-Linked Immunosorbent Assay; Etiology; Fatty Acids; Follicular Fluid; Gene Chips; Glucose; Growth and Development function; Hair; Health; Heavy Metals; Hormones; Human; Immune system; Infant; Intervention Studies; Laboratories; Leptin; Longevity; Measurement; Measures; Metabolic; Methylation; Nail plate; National Institute of Child Health and Human Development; Newborn Infant; Nutritional; Observational Study; Omentum; Personal Satisfaction; Placenta; Plasma; Pregnant Women; Principal Investigator; Proteomics; Protocols documentation; RNA; Reproduction; Research; Research Activity; Research Design; Research Project Grants; Saliva; Scientist; Seminal fluid; Serum; Services; Specimen; Spottings; Study Subject; Techniques; Testing; Tissues; Tocopherols; Triglycerides; Umbilical Cord Blood; Urine; Whole Blood; adolescent health; base; cytokine; design; dietary; epidemiology study; exome sequencing; flexibility; genome wide association study; immune function; innovation; leptin receptor; metabolomics; microbiome analysis; population health; repository; reproductive; research study; sample collection; steroid hormone

The Division of Population Health Research (DiPHR) conducts research on a variety of topics pertaining to human reproduction and development, child and adolescent health and behavior, and care of pregnant women, among other topics. Both observational and interventional research studies are designed and are implemented by DiPHR scientists, and most research includes collection of a diverse array of data and biospecimens. All biospecimens are collected using approved protocols and are de-identified prior to banking in NICHD-supported repositories. The contractor shall receive no identifying or personal health information about the study subjects. A wide range of specimen types are collected including whole blood, cord blood, buffy coats, plasma, serum, urine, saliva, tissues (e.g., placenta, omental fat), hair, nail clippings, follicular and seminal fluid, semen, and newborn blood spots. DiPHR requires analysis of this diverse collection of specimen types for a multitude of factors, including concentrations of reproductive and other hormones; dietary biomarkers; cytokines; indicators of metabolic function including analysis of fatty acids, triglycerides, and glucose; immune function markers; low levels of C-reactive protein; as well as extraction of DNA for whole exome sequencing and methylation analysis; RNA isolation for use in expression arrays; and microbiome analysis. DiPHR requires analysis of collected biological specimens including blood (plasma, serum, WBC, etc.), urine, saliva, adipose tissue, follicular fluid, seminal fluid, and other biologic material relevant for specific research initiatives. Proposed analyses include measurement of concentrations of steroid hormones; measurement of heavy metals; measurement of antioxidants and other nutritional markers including carotenoids, tocopherols, leptin, and leptin receptor; measurement of immune system markers; the flexibility to measure different analytes using multiplex and ELISA techniques; and quantification of metabolomics, proteomics, and genome-wide association studies. DiPHR designs and conducts innovative etiologic and interventional research from preconception through adulthood, focusing on successful reproduction, the health and well-being of pregnant women and their infants, and the optimal growth and development of children and adolescents across the lifespan. To accomplish this, the Division generates a collection of de-identified human biospecimens pertaining to these research activities. The Division requires the services of a biomedical laboratory to provide validated, clinical analyses of biospecimens as well as to modify and/or develop new analysis as needed to measure these biological specimens.

人口健康研究部 (DiPHR) 开展有关人类生殖和发育、儿童和青少年健康和行为以及孕妇护理等各种主题的研究。观察性研究和介入性研究均由 DiPHR 科学家设计和实施，大多数研究包括收集各种数据和生物样本。 所有生物样本均使用经批准的方案收集，并在存入 NICHD 支持的存储库之前进行去识别化处理。承包商不得收到有关研究对象的身份信息或个人健康信息。收集多种样本类型，包括全血、脐带血、血沉棕黄层、血浆、血清、尿液、唾液、组织（例如胎盘、网膜脂肪）、头发、指甲剪、卵泡和精液、精液和新生儿血斑。 DiPHR 需要对多种样本类型进行分析，包括生殖激素和其他激素的浓度；饮食生物标志物；细胞因子；代谢功能指标，包括脂肪酸、甘油三酯和葡萄糖的分析；免疫功能标志物； C反应蛋白水平低；以及提取 DNA 用于全外显子组测序和甲基化分析；用于表达阵列的 RNA 分离；和微生物组分析。 DiPHR 需要分析收集的生物样本，包括血液（血浆、血清、白细胞等）、尿液、唾液、脂肪组织、卵泡液、精液以及与特定研究计划相关的其他生物材料。拟议的分析包括测量类固醇激素的浓度；重金属测量；测量抗氧化剂和其他营养标志物，包括类胡萝卜素、生育酚、瘦素和瘦素受体；免疫系统标记物的测量；使用多重和 ELISA 技术灵活地测量不同的分析物；代谢组学、蛋白质组学和全基因组关联研究的量化。 DiPHR 设计并开展从孕前到成年的创新病因学和介入研究，重点关注成功生殖、孕妇及其婴儿的健康和福祉，以及儿童和青少年整个生命周期的最佳成长和发展。为了实现这一目标，该部门收集了与这些研究活动相关的未识别身份的人类生物样本。该部门要求生物医学实验室提供经过验证的生物样本临床分析，并根据测量这些生物样本的需要修改和/或开发新的分析。