Skin-like wearable biosensors for multimodal mental health biomarker monitoring

用于多模式心理健康生物标志物监测的类肤可穿戴生物传感器

基本信息

批准号：
10750863
负责人：
Chuanzhen Zhao
金额：
$ 7.18万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10750863
关键词：
Acute Affect Anxiety Behavioral Sciences Biological Markers Biosensing Techniques Biosensor Body Temperature Cardiovascular Diseases Chemicals Chronic stress Circadian Rhythms Clinical DNA Data Data Collection Detection Development Device Designs Devices Diagnosis Electrical Engineering Electrodes Environment Feedback Galvanic Skin Response Glucose Goals Health Personnel Health Services Accessibility Health Status Hormones Hospitals Human body Hydrocortisone Hydrogels Immune response Individual Knowledge Measurable Measurement Measures Mental Depression Mental Health Mental Health Services Mental disorders Mentors Molecular Conformation Monitor Morphologic artifacts Motion National Institute of Biomedical Imaging and Bioengineering Noise Patients Persons Physiological Prevention Psychiatry Research Research Project Grants Research Proposals Resources Scientist Secure Signal Transduction Skin Stigmatization Stress System Techniques Technology Testing Time Training Transistors Translations Universities Work acute stress aptamer bioelectronics career cost data exchange design experience fabrication flexibility high risk human subject insight mental disorder prevention mental state monitoring device multimodality new technology novel personalized health care post-doctoral training prevent printed circuit board professor psychobiologic real world application response sensor skills social social stigma stress state stressor technology platform tool wearable device wearable platform wearable sensor technology wireless wireless electronic wireless sensor

项目摘要

PROJECT SUMMARY Mental disorders affect one in four people worldwide (~2 billion people), with the cost of mental health conditions projected to reach $6 trillion by 2030. Unfortunately, mental disorders are difficult to diagnose, monitor, and treat. Repeated triggering of daily stress can also lead to chronic stress, associated with higher risks of mental disorders, weakening immuneresponse, and cardiovascular diseases. Despite the mental health crisis, available resources and access to care scarcely begin to meet the need. Moreover, there are no objective tests or scalable technologies for detecting chronic stress. To advance precision mental healthcare, we need continuous, predictive, and quantitative measurements of mental states for stress, anxiety, and depression. Wearable devices can transform mental health care due to their ability to monitor previously inaccessible biodata. However, there are limited wearable devices designed for mental health monitoring. In the proposed research, I will tackle the mentioned problems in mental health monitoring by developing platform technologies based on skin-like wearable biosensors. The focus of the proposed study is to create a soft and wearable biosensor that can measure multiple mental health biomarkers wirelessly in real-time, providing quantifiable metrics to assist diagnosis, treatment, monitoring, and prevention of mental disorders. Two new technologies will be developed: a soft and wireless patch to measure mental health-related physical biomarkers on the skin and a new organic biosensor platform to monitor chemical biomarkers in sweat. First, I will design a soft and wireless sensor patch to monitor skin conductance changes in response to acute stressors and circadian rhythm. The designed skin conductance sensor patch, composed of intrinsically stretchable and soft materials, will provide seamless integration with skin and accurate measurement with high signal-to-noise ratios. Second, I will fabricate a soft chemical biosensor to monitor the stress hormone in sweat using organic field-effect transistors. A highly sensitive and selective aptamer chemical biosensor will be utilized in a skin-like organic material system. Both alone and combined, the skin-like wearable systems will allow continuous quantitative monitoring of mental health biomarkers, assisting in the prevention and treatment of mental disorders. Professor Zhenan Bao, Professor Leanne Williams, and Stanford University provide the tools and expertise needed to accomplish the proposed research. Working with Professor Bao, a leading scientist in the field of intrinsically stretchable materials, I will acquire scientific skills in the design, fabrication, and characterization techniques of organic materials and bioelectronics. In addition, I will gain experience working with human subjects during this postdoctoral training. For this reason, I am working with Professor Williams, my co-mentor, who is a leading professor in psychiatry and behavioral sciences. Moreover, I will obtain training in psychiatry and electrical engineering by taking classes at Stanford. This environment provides the expertise needed to accomplish the proposed research and provide me with the appropriate training to pursue a career in academic research.

项目概要全球四分之一的人（约 20 亿人）受到精神障碍的影响，精神健康状况的代价是预计到 2030 年将达到 6 万亿美元。不幸的是，精神障碍很难诊断、监测和治疗。日常压力的反复触发也会导致慢性压力，与更高的精神疾病风险相关。疾病、免疫反应减弱和心血管疾病。尽管存在心理健康危机，资源和获得护理的机会几乎无法满足需要。此外，没有客观的测试或可扩展的检测慢性压力的技术。为了推进精准心理保健，我们需要持续、对压力、焦虑和抑郁的心理状态进行预测和定量测量。穿戴式由于设备能够监控以前无法访问的生物数据，因此可以改变精神卫生保健。然而，用于心理健康监测的可穿戴设备有限。在拟议的研究中，我将解决通过开发基于类肤的平台技术，解决心理健康监测中提到的问题可穿戴生物传感器。拟议研究的重点是创建一种柔软的可穿戴生物传感器，可以实时无线测量多种心理健康生物标志物，提供可量化的指标来协助精神障碍的诊断、治疗、监测和预防。将开发两项新技术：用于测量皮肤上与心理健康相关的物理生物标志物的软无线贴片和一种新的有机贴片用于监测汗液中化学生物标志物的生物传感器平台。首先，我将设计一个软无线传感器贴片监测皮肤电导变化以应对急性压力和昼夜节律。设计好的皮肤电导传感器贴片由本质上可拉伸的柔软材料组成，将提供无缝与皮肤融合并以高信噪比进行精确测量。其次，我将制作一个软使用有机场效应晶体管监测汗液中的应激激素的化学生物传感器。一个高度敏感和选择性适体化学生物传感器将用于类皮肤有机材料系统。两个都单独和组合后，类皮肤可穿戴系统将允许对心理进行连续定量监测健康生物标志物，协助预防和治疗精神障碍。鲍哲南教授， Leanne Williams 教授和斯坦福大学提供了实现这一目标所需的工具和专业知识提出的研究。与本质可拉伸领域的领先科学家包教授合作材料，我将获得有机材料的设计、制造和表征技术方面的科学技能材料和生物电子学。此外，在此期间我将获得与人类受试者合作的经验博士后培训。出于这个原因，我正在与我的共同导师威廉姆斯教授合作，他是一位领先的精神病学和行为科学教授。此外，我将获得精神病学和电气方面的培训通过在斯坦福大学学习工程学。该环境提供了完成以下任务所需的专业知识提出研究并为我提供适当的培训以从事学术研究职业。