The NYU Children’s Health & Environment Study: an ECHO Cohort

纽约大学儿童健康中心

• 批准号: 10745102
• 负责人: Leonardo Trasande
• 金额: $ 859.93万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745102
• 关键词: Air Pollutants; Area; Aromatic Polycyclic Hydrocarbons; Asian; Birth; Black race; COVID-19; COVID-19 pandemic; Chemical Exposure; Chemicals; Child; Child Health; Clinic; Cohort Studies; Collection; Complement; Conceptions; Couples; Data; Data Collection; Development; Discipline of obstetrics; Embryo; Enrollment; Environment; Environmental Exposure; Environmental Health; Exposure to; Fertility; Fetal Growth; Funding; Future Generations; Generations; Growth; Health; Hispanic; Human; Infant; International; Laboratories; Lead; Life; Long-Term Effects; Low Birth Weight Infant; Measures; Mediating; Melamine; Mothers; National Institute of Environmental Health Sciences; New York City; Obesity; Organophosphates; Outcome; Participant; Patients; Personal Satisfaction; Persons; Pesticides; Phase; Pilot Projects; Plethysmography; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Procedures; Productivity; Protocols documentation; Publications; Recommendation; Research; Resources; Risk Factors; Roentgen Rays; SARS-CoV-2 infection; Sampling; Science; Subfecundity; System; Time; Translations; United States National Institutes of Health; Urine; Visit; absorption; chemical association; cohort; design; development policy; digital platform; experience; fetal; follow-up; heterocyclic aromatic amines; infancy; infertility treatment; innovation; medical schools; novel; pandemic disease; participant retention; patient engagement; phthalates; postnatal; pregnant; prenatal; prenatal exposure; programs; public health insurance; recruit; time-to-pregnancy; wearable device; working group

PROJECT SUMMARY NYU Grossman School of Medicine (NYUGSOM) presents an application for: (1) ongoing enrollment of pregnancies, conceiving partners and their children from the NYU Children’s Health and Environment Study (NYU CHES, UG3/UH3OD023305) into the Environmental influences on Child Health Outcomes Program (ECHO) Cohort, (2) follow up of already enrolled mother-infant pairs and (3) piloting of the ECHO preconception study. NYU CHES enrolls pregnant people <18 weeks gestation from NYUGSOM-affiliated obstetric clinics. The cohort is diverse ( 50% Hispanic, 9.7% Asian, 5.2% Black; 49% Public Insurance ) and Over the past seven years, we exceeded our expected enrollment by over 100% (>2000 mother-child pairs compared with the planned 1000). We sustained strong retention despite the COVID-19 pandemic, with nearly 72-83% visit completion at each of five time points in infancy (4-7, 8-11, 12-27, 18-23 and 24-35 months) and biospecimen collection rates as high as 80% in pregnancy. We contributed substantially to ECHO-wide science, with an emphasis on chemical/physical environmental exposures (our Specialized Exposure area). PI Trasande was the inaugural co-chair of the Obesity Working Group, and NYU CHES contributed specialized measures of obesity (our Specialized Outcome area) through the application of plethysmography and dual-absorption X-ray absorptiometry. We vigorously responded to the pandemic by co-leading the COVID-19 Working Group, completing a multi-cohort study of SARS-CoV-2 infection and birth outcomes supported by an ECHO Supplement, and obtaining funding from the NIH RECOVER Initiative to identify long-term effects of SARS-CoV-2 infection in children. Our scientific productivity is manifested not only in our 32 cohort-specific publications, but more importantly in our contribution to a plethora of ECHO-wide publications that span all five of ECHO’s outcomes. We propose to continue our enrollment of new pregnancies at the rate we achieved during the previous funding period (520 mother-child pairs/year). We will continue to implement the ECHO Cohort Data and Biospecimen Collection Protocol and its central data capture system (REDCap Central) among all participants. We anticipate enrolling 200 NYU CHES mothers and their partners each year into the Preconception Pilot Study as soon as feasible after delivery. We suggest innovative science for the pregnancy and preconception cohorts, including expanding our study of chemical and physical exposures to include novel contaminants such as heterocyclic aromatic amines and melamine, led by Co-I Kannan, who directs a NIEHS Human Health Exposure Analysis Resource laboratory (U2CES026542). We apply an innovative digital platform for participant engagement, retention and data collection developed by Vibrent Health for the NIH All of Us Study, which we recommend for broader application in the ECHO Program. PI Trasande is an international leader in children’s environmental health (CEH) and directs an NIEHS Collaborative Center in CEH Research and Translation. broadly representative of NYC pregnancies.

项目概要 纽约大学格罗斯曼医学院 (NYUGSOM) 提出申请：(1) 持续招生 纽约大学儿童健康与环境研究中的怀孕、怀孕伴侣及其孩子 （NYU CHES，UG3/UH3OD023305）纳入环境对儿童健康结果的影响计划 (ECHO) 队列，(2) 已登记的母婴对的随访和 (3) ECHO 的试点 NYU CHES 招募 NYUGSOM 附属机构妊娠 <18 周的孕妇。 该队列是产科诊所。 各种各样的 （ 50% 西班牙裔，9.7% 亚裔，5.2% 黑人；49% 公共保险 ） 和 过去七年，我们的入学人数超出了预期 超过 100%（超过 2000 对母子，而计划的 1000 对）。 尽管发生了 COVID-19 大流行，但在婴儿期五个时间点（4-7、 8-11、12-27、18-23和24-35个月），妊娠期生物样本采集率高达80%。 对 ECHO 范围内的科学做出了重大贡献，重点是化学/物理环境 PI Trasande 是肥胖工作组的首任联合主席。 集团和 NYU CHES 通过 我们对体积描记法和双吸收X射线吸收测定法的应用做出了积极响应。 共同领导 COVID-19 工作组，完成 SARS-CoV-2 的多队列研究，以应对大流行 感染和出生结果由 ECHO 补充支持，并从 NIH 获得资金 RECOVER 计划旨在确定 SARS-CoV-2 感染对儿童的长期影响 我们的科学。 生产力不仅体现在我们的 32 个特定群体的出版物中，更重要的是体现在我们的 为涵盖 ECHO 所有五项成果的大量 ECHO 出版物做出贡献。 继续按照我们在上一个资助期间实现的速度（520 母子对/年）我们将继续实施 ECHO 队列数据和生物样本收集。 我们预计所有参与者都会参与协议及其中央数据采集系统（REDCap Central）。 每年有 200 名 NYU CHES 母亲及其伴侣尽快参与孕前试点研究 我们建议对怀孕和孕前人群进行创新科学，包括 扩大我们对化学和物理暴露的研究，以包括杂环化合物等新型污染物 芳香胺和三聚氰胺，由 Co-I Kannan 领导，他负责 NIEHS 人类健康暴露分析 资源实验室（U2CES026542）我们应用创新的数字平台来促进参与者的参与， Vibrent Health 为 NIH All of Us 研究开发的保留和数据收集，我们推荐用于 PI Trasande 是儿童环保领域的国际领导者。 健康 (CEH) 并指导 NIEHS 的 CEH 研究和翻译合作中心。 广泛代表纽约市的怀孕情况。