Preconceptual Bisphenol and Phthalate Effects on Early Embryonic Development

孕前双酚和邻苯二甲酸盐对早期胚胎发育的影响

基本信息

批准号：
10113613
负责人：
Leonardo Trasande
金额：
$ 55.8万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10113613
关键词：
Abdomen Academic Medical Centers Age-Months Aluminum American Biological Assay Biological Markers Birth Butylene Glycols Cardiovascular Diseases Cardiovascular Physiology Categories Chemical Exposure Chemicals Child Childhood Cohort Studies Conceptions Couples Cyclohexanes Data Development Dicarboxylic Acids Diet Dietary Factors Diethylhexyl Phthalate Dimensions EFRAC Echocardiography Elderly Embryo Embryonic Development Embryonic and Fetal Development Endocrine Environmental Exposure Environmental Health Epidemiologist Esters Exposure to Failure Fathers Fatty Liver Fatty acid glycerol esters Fertility Fetal Growth Fetal Growth Retardation First Pregnancy Trimester Future Generations Growth Health Human Impairment Infant International Laboratories Left Length Life Literature Liver Longitudinal Studies Low Birth Weight Infant Maleates Maternal Age Measurement Measures Mediating Methodology Modification Mothers New York Outcome Oxidative Stress Paper Perinatal Phenotype Plastics Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth Prenatal care Process Reproductive Technology Risk Factors Sampling Shapes Socioeconomic Status Stroke Volume Subfecundity Succinates Time Triad Acrylic Resin Ultrasonography United States Urine Ventricular End-Diastolic Volumes Weight Gain Woman Work abdominal fat adverse birth outcomes base bisphenol A cardiovascular risk factor cohort early life exposure experience fetal heart dimension/size high risk infertility treatment innovation lifestyle factors male medical schools multi-ethnic novel organ growth oxidant stress phthalates postnatal prenatal prenatal exposure prospective sample collection time-to-pregnancy urinary

项目摘要

Project Summary NYU School of Medicine, Erasmus University Medical Center and New York State Department of Health respond to PA-16-160, proposing to study preconception and prenatal phthalate and bisphenol exposures in relationship to time to pregnancy, embryonic and fetal growth, and infant growth. A substantial literature suggests that a diverse array of synthetic chemicals may influence developmental endocrine programming and provoke oxidant stress, a major pathophysiologic mechanism underlying adverse birth outcomes. These include: phthalates (which are used to soften plastics and as scents); and bisphenols (used in aluminum can linings and thermal paper receipts). Yet, longitudinal studies of early life exposure to phthalates and bisphenols and their effects on fetal and postnatal growth in humans have been limited, and the few studies to date have not yielded consistent findings. We propose to analyze samples from preconception, three timepoints in pregnancy (7, 13 and 30 weeks) in 1000 father-mother-infant triads in Generation R Next, a prospective, longitudinal multi-ethnic birth cohort study. Unique embryonic and placental assessments will have been performed through repeated ultrasounds at 7, 9 and 11 weeks. These analyses will also capture embryonic and placental growth as well as liver growth and cardiac size. The proposed study will also leverage echocardiography and abdominal sonography performed at 1 and 12 months of age, which will assess dimensions such as left ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and mass, as well as abdominal fat and liver steatosis. The PI (Trasande) is an internationally renowned expert in children's environmental health and the proposed study also benefits from strong support from Generation R Next, including the Director (Jaddoe), an experienced pediatric and perinatal epidemiologist with a strong record in studying early determinants of cardiovascular disease. Analyses will be performed by K. Kannan at Wadsworth Laboratories of the New York State Department of Health, who has deep experience with precise measurement of phthalate and bisphenol biomarkers in urine. Given the long-term implications of the “thrifty phenotype,” if preconceptional exposures are found to be important in shaping fetal growth and influencing birth outcomes, then guidance in anticipation of conception to limit environmental exposures before pregnancy may be indicated. Presently, such guidance is limited in the United States, save perhaps from couples seeking advanced reproductive technology.

项目概要纽约大学医学院、伊拉斯姆斯大学医学中心和纽约州卫生部回应 PA-16-160，提议研究孕前和产前邻苯二甲酸盐和双酚暴露与怀孕时间、胚胎和胎儿生长以及婴儿生长的关系大量文献。表明多种合成化学物质可能影响发育内分泌编程和引发氧化应激，这是不良出生结果的主要病理生理机制。包括：邻苯二甲酸盐（用于软化塑料和用作香料）和双酚（用于铝罐）；然而，对生命早期接触邻苯二甲酸盐和双酚的纵向研究。它们对人类胎儿和产后生长的影响有限，迄今为止为数不多的研究我们建议对怀孕前的三个时间点的样本进行分析。下一代 R 世代中 1000 个父-母-婴三联体的怀孕（7、13 和 30 周）纵向多种族出生队列研究将进行独特的胚胎和胎盘评估。通过在第 7、9 和 11 周重复进行超声检查，这些分析还将捕获胚胎。拟议的研究还将利用胎盘生长以及肝脏生长和心脏大小。在 1 个月和 12 个月大时进行超声心动图和腹部超声检查，以评估维度，例如左心室舒张末期容积、收缩末期容积、每搏输出量、射血分数和肿块，以及腹部脂肪和肝脏脂肪变性 PI (Trasande) 是国际知名的。儿童环境健康专家和拟议的研究也受益于以下机构的大力支持 R 世代，包括主任 (Jaddoe)，一位经验丰富的儿科和围产期流行病学家， K. 在研究心血管疾病的早期决定因素方面有着出色的记录。纽约州卫生部Wadsworth实验室的Kannan，经验丰富考虑到尿液中邻苯二甲酸盐和双酚生物标志物的长期影响。 “节俭表型”，如果发现孕前暴露对于塑造胎儿生长和发育很重要出生结果，然后指导影响受孕预期以限制受孕前的环境暴露目前，这种指导在美国是有限的，也许除了从怀孕。寻求先进生殖技术的夫妇。