NICHD Global Network for Women’s and Children’s Health Research: Research Units

NICHD 全球妇女和儿童健康研究网络：研究单位

• 批准号: 10746195
• 负责人: William A Petri
• 金额: $ 53.51万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-10 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746195
• 关键词: Address; Adherence; Adoption; Anemia; Azithromycin; Bacteriuria; Bangladesh; Birth; Budgets; COVID-19; Cellular Phone; Child; Child Development; Child Health; Childbirth; Childhood; Clinical Protocols; Clinical Research; Clinical Research Protocols; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Communicable Diseases; Communities; Conduct Clinical Trials; Country; Development; Diarrhea; Enrollment; Environment; Equipment; Equity; Ethical Review; Ethics; Fertility; Gender; Goals; Government; Grant; Health; Health care facility; Hospitals; Human Genetics; Human Resources; Human Rights; Immunology; Impairment; Income; Infant; Infant Malnutrition; Inservice Training; International; Kinetics; Laboratories; Lactation; Leadership; Low Birth Weight Infant; Mainstreaming; Maternal Mortality; Maternal and Child Health; Maternal-fetal medicine; Modeling; Mothers; National Institute of Child Health and Human Development; Neonatal Mortality; Neonatology; Neurocognitive; Occupational activity of managing finances; Oral; Outcome; Outcome Study; Paper; Pharmacodynamics; Pharmacology; Policies; Population; Pregnancy; Pregnant Women; Principal Investigator; Protocols documentation; Publications; Publishing; Recording of previous events; Registries; Rehydration Solutions; Reproductive Health; Research; Research Personnel; Reservations; Respiratory Tract Infections; Role; Rural; Rural Population; SARS-CoV-2 infection; Science; Scientist; Sepsis; Services; Site; Structure; Training; Translations; Underrepresented Minority; Universities; Urban Population; Virginia; Visit; Woman; clinical research site; community based care; data centers; data communication; design; dietary supplements; electronic data; equity, diversity, and inclusion; experience; follow-up; gender-based violence; global health; health of the mother; implementation science; improved; innovation; invention; laboratory facility; multidisciplinary; neonatal health; neurodevelopment; novel; nutrition; pediatric pharmacology; prevent; recruit; vaccine failure; vaccinology

PROJECT SUMMARY Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal mortality from childbirth, vaccine failure and impaired child development. The UVA-icddrb Research Unit (RU) addresses critical needs of women and young children by bringing to the Network strengths in infectious diseases, lactation, pharmacology, neurocognitive development, human genetics, maternal-fetal medicine, immunology, vaccinology and CTSA coordination. The RU has access to nearly 8000 pregnant women annually at our existing clinical trial sites, is highly attuned to ethical and cultural issues with local community and ethical review boards, and leads Network studies of COVID-19 in pregnancy and maternal anemia. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 30 years co-led multidisciplinary teams studying maternal-child health, with over 170 co- publications and ten on-going or completed clinical studies in the last five years. They are joined at icddr,b and UVA by a diverse and multidisciplinary core team of 19 accomplished investigators in maternal-child health. Innovation: The RU conceptualized the multi-site study of COVID-19 infection during pregnancy that demonstrated minimal impact on birth outcomes, is leading a study of the role of maternal anemia on low-birth weight infants, has multi-site Network-approved protocols on maternal nutritional supplements and on asymptomatic bacteriuria and has pioneered electronic data capture for the Network. Special capabilities include infectious diseases, pharmacology, lactation, and novel clinical trial designs through the CTSA. Approach: The RU has conducted 12 clinical trials since 2016 with 99% adherence to follow-up visits, and access to 8000 pregnant women annually in existing clinical trial sites. Science to policy translation catalyzed by the partnership of the icddr,b with the Government of Bangladesh, as evidenced by the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide, and the Matlab model of community -based care. Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health has a unique focus on Global Health, with over $16 million in annual grant support and over two dozen active clinical protocols. UVa-icddrb unique and complementary expertise will continue to bring unparalleled strengths to the Network’s goal of making sustainable improvements in maternal and child health.

项目概要 意义：孟加拉国和其他中低收入国家的母亲和儿童遭受的苦难尤为严重 孕产妇和婴儿营养不良、腹泻和呼吸道感染导致的新生儿死亡以及孕产妇 分娩、疫苗失败和儿童发育受损导致的死亡率 UVA-icddrb 研究单位 (RU) 通过利用网络在传染病方面的优势，关键解决了妇女和幼儿的需求 疾病、哺乳、药理学、神经认知发育、人类遗传学、母胎医学、 RU 可以接触到近 8000 名孕妇。 每年在我们现有的临床试验地点进行一次，高度关注当地社区的道德和文化问题 和伦理审查委员会，并领导了 COVID-19 在妊娠和孕产妇贫血中的网络研究。 调查人员：RU 首席调查员 (PI) William Petri 和高级外国调查员 (SFI) Rashidul Haque 30 年来共同领导了研究母婴健康的多学科团队，该团队有超过 170 名共同研究人员。 过去五年中发表的出版物和十项正在进行或已完成的临床研究它们在 icddr、b 和 中加入。 UVA 由多元化、多学科的核心团队组成，该团队由 19 名母婴健康方面卓有成效的研究人员组成。 创新：RU 构思了妊娠期间 COVID-19 感染的多中心研究， 对出生结果的影响极小，正在领导一项研究，证明孕产妇贫血对低产的影响 体重婴儿，拥有多站点网络批准的关于孕产妇营养补充剂和 无症状菌尿并开创了网络电子数据采集的特殊功能。 包括传染病、药理学、哺乳以及通过 CTSA 进行的新颖临床试验设计。 方法：RU 自 2016 年以来已开展 12 项临床试验，随访依从率为 99%，并且 每年在现有的临床试验地点接触 8000 名孕妇，促进科学到政策的转化。 正如世界范围内的情况所证明的那样，ICDDR,b 与孟加拉国政府建立了伙伴关系 口服补液溶液的实施，由 icddr,b 发现并在全国范围内采用，以及 Matlab 以社区为基础的护理模式。 环境： RU 拥有无与伦比的多学科实力、实验室设施和通往城市的通道 icddr,b 是世界上最重要的全球卫生机构之一。 发展中国家拥有超过 200 项活跃的临床试验/方案 UVa 传染病部门。 国际卫生部门对全球卫生有着独特的关注，每年提供超过 1600 万美元的赠款支持和 超过二十个活跃的临床方案将继续带来 UVa-icddrb 独特且互补的专业知识。 该网络对可持续改善孕产妇和儿童健康的目标具有无与伦比的优势。

项目成果

Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.

孟加拉国农村地区妊娠早期的全身炎症、肠病性大肠杆菌和微量营养素缺乏可能是早产的预测因素：一项前瞻性研究。

• 发表时间: 2024-01-24
• 作者: Gerety, Meghan K;Kim, Debora K;Carpenter, Rebecca M;Ma, Jennie Z;Chisholm, Christian;Taniuchi, Mami;Islam, Md Ohedul;Pholwat, Suporn;Platts;Siraj, Md Shahjahan;Billah, Sk Masum;Haque, Rashidul;Petri Jr, William A
• 通讯作者: Petri Jr, William A

Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health.

建立孕产妇和新生儿登记电子平台：全球妇幼健康网络孟加拉国站的经验

• 发表时间: 2020-11-30
• 影响因子: 3.4
• 作者: Billah, Sk Masum;Haque, Rashidul;Chowdhury, Atique Iqbal;Siraj, Md Shahjahan;Rahman, Qazi Sadequr;Hossain, Tanvir;Alam, Asraful;Alam, Masud;Marie, Chelsea;McGrath, Beth;El Arifeen, Shams;Petri Jr, William A
• 通讯作者: Petri Jr, William A