University of Virginia - icddr,b Research Unit for Women's and Children's Health Research

弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位

• 批准号: 10413887
• 负责人: William A Petri
• 金额: $ 30.17万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413887
• 关键词: Address; Adoption; African; Asian; Bangladesh; Birth Weight; Cessation of life; Child; Child Development; Child Health; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Communicable Diseases; Communities; Complement; Coordination and Collaboration; Country; Data; Development; Developmental Delay Disorders; Diarrhea; Enteral; Environment; Facility Accesses; Functional disorder; Goals; Government; Grant; Health; Health Status; Human Genetics; Immunology; Impairment; Income; Infant Malnutrition; Infection; Inflammation; Institutes; International; Intervention; Knowledge; Lead; Leadership; Live Birth; Malnutrition; Maternal Mortality; Maternal and Child Health; Maternal-fetal medicine; Modeling; Mothers; Mucous Membrane; Neonatal Mortality; Neonatology; Neurocognitive; Observational Study; Oral; Parasitology; Positioning Attribute; Pregnancy; Pregnant Women; Principal Investigator; Public Health; Publications; Recording of previous events; Rehydration Solutions; Research; Research Peer Review; Research Personnel; Respiratory Tract Infections; Role; Rotavirus Vaccines; Rural; Rural Population; Scientist; Site; Sustainable Development; Testing; United Nations; Universities; Urban Population; Virginia; Weight Gain; Woman; Work; authority; base; community based care; dietary supplements; experience; global health; improved; infant nutrition; innovation; invention; laboratory facility; microbiome; molecular diagnostics; mortality; multidisciplinary; neonatal health; neurodevelopment; novel; nutrition; oral vaccine; pollutant; population health; prevent; vaccine failure; vaccinology

Project Summary We propose that the University of Virginia (UVa) and icddr,b become a Research Unit (RU) within the Global Network for Women's and Children's Health Research. Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, vaccine failure and impaired child development. The UVa-icddrb Research Unit (RU) will address these critical needs of women and young children by complementing the existing Network strengths with added scientific expertise in infectious diseases, neurocognitive development, human genetics, maternal-fetal medicine, immunology, and vaccinology. The RU will also provide extraordinary access to rural and urban populations for clinical trials. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 25 years co-led multidisciplinary teams studying maternal-child, with over 100 co-publications and eight on-going clinical trials or observational studies. They are joined at icddr,b by a multidisciplinary team of F. Qadri (Immunology), K. Zaman (Vaccinology), F. Tofail (Child Development), M. Billah and S. El Arifeen (Maternal and Child Health), T. Ahmed (infant nutrition) and at UVa by C. Chisholm (ob/gyn) and R. Sinkin (neonatology). Innovation: The RU has a long history of innovative studies and expertise in maternal-child health, including the impact of infection and inflammation on child neurocognitive development, role of airborne pollutants on respiratory infection, function of gut damage in oral vaccine failure and malnutrition. Approach: The RU will work within the Network to promote innovative studies that have the potential to lead to actionable and sustainable improvement in maternal and child health through the partnership of the RU with the government of Bangladesh (manifest through the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide of the Matlab model of community based care). Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health is the largest research unit at UVa with over $20 million in annual grant support and over two dozen active clinical protocols. The quarter of a century UVa-icddrb collaboration and unique and complementary expertise promises to bring unparalleled strengths to the Network's goal of making sustainable improvements in maternal and child health.

项目概要 我们建议弗吉尼亚大学 (UVa) 和 icddr,b 成为全球研究中心 (RU) 妇女和儿童健康研究网络。 意义：孟加拉国和其他中低收入国家的母亲和儿童遭受的苦难尤为严重 孕产妇和婴儿营养不良、腹泻和呼吸道感染导致的新生儿死亡、疫苗 失败和儿童发育受损。 UVa-icddrb 研究单位 (RU) 将满足这些关键需求 通过增加科学专业知识来补充现有网络优势，从而保护妇女和幼儿 在传染病、神经认知发育、人类遗传学、母胎医学、免疫学、 和疫苗学。 RU 还将为农村和城市人口提供临床试验的非凡机会。 调查人员：RU 首席调查员 (PI) William Petri 和高级外国调查员 (SFI) Rashidul Haque 25 年来一直共同领导多学科团队研究母婴，并发表了 100 多篇联合出版物 以及八项正在进行的临床试验或观察性研究。他们由多学科团队加入 icddr,b F. Qadri（免疫学）、K. Zaman（疫苗学）、F. Tofail（儿童发展）、M. Billah 和 S. El Arifeen 教授 （妇幼健康）、T. Ahmed（婴儿营养）以及 UVa 的 C. Chisholm（妇产科）和 R. Sinkin （新生儿学）。 创新：RU 在母婴健康方面拥有悠久的创新研究和专业知识历史，包括 感染和炎症对儿童神经认知发育的影响，空气污染物的作用 呼吸道感染、口服疫苗失败和营养不良中肠道功能受损。 方法：RU 将在网络内开展工作，促进有潜力带来成果的创新研究 通过与 RU 的合作，切实可行且可持续地改善孕产妇和儿童健康 孟加拉国政府（通过在全球范围内实施口服补液盐来体现， icddr,b 发现并在全国范围内采用社区护理的 Matlab 模型）。 环境： RU 拥有无与伦比的多学科实力、实验室设施和通往城市的通道 以及农村人口的母亲和儿童。 icddr,b 是世界上最重要的全球卫生机构之一 发展中国家有超过 200 个活跃的临床试验/方案。弗吉尼亚大学传染病科 国际健康是弗吉尼亚大学最大的研究单位，每年提供超过 2000 万美元的资助支持 超过两打活跃的临床方案。 UVa-icddrb 四分之一个世纪的合作和独特且 互补的专业知识有望为网络的目标带来无与伦比的优势 可持续改善孕产妇和儿童健康。