Miami-ECHO: A Diverse Cohort of Mothers, Children and Fathers in Miami-Dade County

迈阿密-ECHO：迈阿密-戴德县的母亲、儿童和父亲的多元化群体

• 批准号: 10746614
• 负责人: Michael John Paidas
• 金额: $ 235.49万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746614
• 关键词: Address; Affect; African American population; African Caribbean; Age; Area; Asian population; Automobile Driving; Biological; Biological Process; Birth; Caring; Child; Child Development; Child Health; Childhood; Cohort Studies; Communities; Complex; Conceptions; County; Data; Discipline; Discrimination; Disease susceptibility; Disparity; Disparity population; Economics; Elderly; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Family Planning; Fathers; Florida; Funding; Genes; Genome; Goals; Haitian; Health; Hispanic; Home; Individual; Inequity; Infant Health; Infrastructure; Insurance Coverage; Language; Latino Population; Life Experience; Linguistics; Maternal and Child Health; Mediating; Minority; Minority Women; Morbidity - disease rate; Mothers; Not Hispanic or Latino; Outcome; Parents; Perinatal; Persons; Population; Population Distributions; Population Heterogeneity; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Race; Research; Role; Science; Scientific Advances and Accomplishments; Shapes; Social Environment; Social Identification; Social support; Stress; United States National Institutes of Health; Woman; Work; cohort; disorder risk; early childhood; ethnic diversity; ethnic minority; ethnic minority population; experience; global health; health disparity; improved; infant death; member; metropolitan; middle childhood; multi-racial; multidisciplinary; neurodevelopment; offspring; outcome disparities; perinatal period; prenatal; programs; psychologic; racial diversity; racial minority; racial minority population; racial population; racism; recruit; skin color; social; social genomics; social health determinants; social stressor; socioeconomic adversity

PROJECT SUMMARY/ABSTRACT Disparities in maternal-child health increase generationally because stress experienced by mothers can be transferred to their children, with both biological and psychological consequences. Without clear understanding of factors driving these disparate outcomes and without longitudinal assessments across racial and ethnic groups, inequities will persist. The Environmental influences on Child Health Outcomes (ECHO) Program aims to understand the effects of early environmental factors on child health and development, and therefore needs a diverse cohort of children and their parents who represent the variety of U.S. populations, especially racial and ethnic minority populations who often are at the intersection of socioeconomic adversity and social stressors related to race/ethnicity. We propose to establish the Miami-ECHO cohort of racially and ethnically diverse mothers, children, and fathers. We will recruit and retain a racially and ethnically diverse cohort of pregnant women (N=1,250), their offspring, and the conceiving father from Miami-Dade County (MDC), Florida. In addition, we will recruit and retain 60-80% of the cohort mothers into the ECHO preconception pilot protocol. MDC is a minority-majority county with a population of 69.4% Hispanic/Latinos (including Afro-Caribbeans), 17.7% African Americans, 12.9% Non-Hispanic Whites, 3% Asians, and 1.3% multi-racial individuals.to one of the most ethnically and culturally diverse U.S. populations. MDC, however, is not yet represented in the ECHO Program. Our diverse, multi-disciplinary team has access to the largest populations of pregnant women and those giving birth in MDC, and to community-based infrastructures caring for the most vulnerable women in the region for over 40 years. Furthermore, to advance ECHO science, we will address these aims: A) Examine social environment and placental genome influences on children's neurodevelopment and global health. We will determine whether the placental genome mediates the relationship between pre- and perinatal social environment and children's neurodevelopment and global health during early and middle childhood; and identify the interactive (gene x epigene x social environment) effects on children's neurodevelopment and global health during early and middle childhood. B) Identify factors that protect against the effects of discrimination on children's neurodevelopment and global health. We will distinguish the effects of maternal and paternal discrimination – separately and in combination – on children's neurodevelopment and global health from early to middle childhood; and determine the degree to which the social environment, social identity (race, ethnicity, skin color, nativity), and social support mediate the effects of discrimination on children's neurodevelopment and global health. C) Identify the effects of modifiable social determinants of health and access to family planning during the pre-conception period on subsequent pregnancy morbidity and birth outcomes.

项目概要/摘要 由于母亲所承受的压力可能会影响母婴健康的代际差异。 转移给他们的孩子，造成了生理和心理上的后果，但没有明确的认识。 导致这些不同结果的因素，并且没有跨种族和民族的纵向评估 环境对儿童健康结果的影响 (ECHO) 计划的目标将持续存在。 了解早期环境因素对儿童健康和发展的影响，因此需要 代表美国不同人群，尤其是种族和群体的多元化儿童及其父母 经常处于社会经济逆境和社会压力源交汇处的族裔人口 我们建议建立种族和族裔多元化的迈阿密-ECHO 队列。 我们将招募并保留不同种族和民族的孕妇。 女性 (N=1,250)、她们的后代以及来自佛罗里达州迈阿密戴德县 (MDC) 的怀孕父亲。 我们将招募并保留 60-80% 的队列母亲参加 ECHO MDC 孕前试点方案。 少数族裔占多数的县，人口 69.4% 是西班牙裔/拉丁裔（包括非裔加勒比人），17.7% 是非洲人 美国人中，12.9% 是非西班牙裔白人，3% 是亚洲人，1.3% 是多种族人士。 然而，种族和文化多元化的美国人口尚未在 ECHO 计划中得到体现。 我们多元化、多学科的团队可以接触到最多的孕妇和那些正在接受治疗的人 在 MDC 出生，以及照顾该地区最弱势妇女的社区基础设施 40 多年来。甚至，为了推进 ECHO 科学，我们将实现以下目标：A) 检查社会 环境和胎盘基因组对儿童神经发育和全球健康的影响。 将确定胎盘基因组是否介导产前和围产期社交之间的关系 儿童早期和中期的环境与儿童神经发育和全球健康； 互动（基因 x 表观基因 x 社会环境）对儿童神经发育和全球健康的影响 B) 确定儿童早期和中期免受歧视影响的因素。 我们将区分母亲和父亲对儿童神经发育和整体健康的影响。 歧视（单独或组合）从早期就对儿童神经发育和全球健康产生影响 到童年中期；并确定社会环境、社会身份（种族、民族、 肤色、出生地）和社会支持调节歧视对儿童神经发育和发育的影响 C) 确定可改变的健康社会决定因素和与家庭的联系的影响。 在受孕前阶段对随后的妊娠发病率和出生结果进行规划。