Body Region Specificity for Neuromodulation of the Gut-Brain Axis in Functional Dyspepsia

功能性消化不良肠脑轴神经调节的身体区域特异性

基本信息

批准号：
10739373
负责人：
Roberta Sclocco
金额：
$ 13.43万
依托单位：
SPAULDING REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-05 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10739373
关键词：
Abdomen Acupuncture Points Acupuncture Therapy Adrenal Glands Afferent Neurons Anatomy Animal Model Anti-Inflammatory Agents Atmosphere Award Biomedical Engineering Body Regions Brain Brain Stem Breathing Cell Nucleus Cine Magnetic Resonance Imaging Clinical Complement Conduct Clinical Trials Cutaneous Data Diagnosis Dissociation Distant Dyspepsia Efferent Neurons Electroacupuncture Ensure Environment Expectancy Fascia Food Four-dimensional Functional Magnetic Resonance Imaging Gastroenterology Gastrointestinal Diseases Gastrointestinal tract structure Goals Health Hindlimb Hospitals Human Image Institution Intake Integrative Medicine Intervention Leg Link Location Longitudinal Studies Magnetic Resonance Imaging Mediating Mentors Mentorship Neuroanatomy Nonpharmacologic Therapy Nucleus solitarius Outcome Pain Pathway interactions Patient Self-Report Patients Peripheral Peristalsis Physiological Physiology Pilot Projects Placebo Effect Placebos Publications Publishing Randomized Rehabilitation therapy Research Research Personnel Resolution Response Generalization Rodent Rodent Model Role Site Specificity Stomach Supervision Symptoms Technical Expertise Therapeutic Training Translational Research Upper digestive tract structure Visceral Work autonomic reflex biomedical imaging brain magnetic resonance imaging career career development cell motility clinical efficacy clinical translation contextual factors contrast enhanced disorders of gut-brain interaction dorsal motor nucleus expectation gastrointestinal gastrointestinal symptom gut-brain axis imaging approach insight kinematics medical schools motility disorder multidisciplinary nerve supply neural circuit neuroimaging neuroregulation non-invasive imaging psychological outcomes response skills somatosensory spatiotemporal success tool translational neuroscience translational research program

项目摘要

PROJECT SUMMARY/ABSTRACT The candidate is an accomplished bioengineer with formal training in human brain-body imaging and neuromodulation, and a commitment to a career in translational research in the study of integrative medicine and neurogastroenterology. The candidate’s long-term career goal is to develop a translational research program in integrative medicine approaches for gut-brain modulation. The candidate’s short-term career goals are to 1) transition towards independence through mentored training focused on integrative medicine, placebo research, and neurogastroenterology; 2) weave new research skills into her technical imaging background, with potential for longitudinal studies evaluating non-pharmacological therapies; 3) produce the data and publications necessary to transition into a successful R01 application. This application outlines the institutional commitment, research plan, career development activities, and key mentors involved to ensure the candidate accomplishes these goals. In recently published work, the candidate has demonstrated the feasibility of using dynamic cine- MRI for non-invasive characterization of multiple aspects of gastric function in healthy subjects and patients with functional dyspepsia (FD). In this proposal, the candidate seeks to apply MRI-based tools to compare the impact of stimulation at different acupoint locations on brainstem neurocircuitry and gastric motility in patients with FD, as well as the interaction between treatment and expectancy manipulation. The specific goals of this study are to 1) evaluate the underlying brainstem neurocircuitry of transcutaneous electrical acupoint stimulation (TEAS) in FD; 2) compare the effect of leg (acupoint ST36) versus abdomen (acupoint ST25) TEAS on gastric motility in FD; 3) evaluate the effect of expectancy manipulation on meal- evoked symptoms and physiological outcomes. As an integral part of this proposal, the candidate’s career development will be complemented by participation in advanced coursework to develop expertise in placebo research, integrative medicine, gastroenterology, and conduct of clinical trials. A formal mentorship committee, consisting of multidisciplinary experts in placebo research, neurogastroenterology, neuroimaging, acupuncture, and integrative medicine, will provide supervision, guidance, and assistance for the candidate to achieve her goals. The research environment, which includes the Spaulding Rehabilitation Hospital, the Athinoula A. Martinos Center for Biomedical Imaging, the Center for Integrative Pain Neuroimaging (CiPNI), the Gastrointestinal Unit and MGH Center for Neurointestinal Health, and the Harvard Medical School will provide a rich, collaborative, and intellectually stimulating atmosphere to ensure the candidate’s success. Through this award, the candidate will emerge as an independent investigator by contributing to our understanding of the brain-gut mechanisms supporting acupoint-specific effects in patients with a disorder of gut-brain interactions.

项目概要/摘要候选人是一位出色的生物工程师，接受过人脑-身体成像方面的正规培训神经调节，以及对综合医学研究转化研究事业的承诺候选人的长期职业目标是开发转化研究计划。肠脑调节的综合医学方法候选人的短期职业目标是 1) 通过以综合医学、安慰剂研究为重点的指导培训向独立过渡，和神经胃肠病学；2）将新的研究技能融入她的技术成像背景中，具有潜力用于评估非药物疗法的纵向研究；3) 生成数据和出版物过渡到成功的 R01 申请所必需的该申请概述了机构承诺，研究计划、职业发展活动以及确保候选人实现目标的关键导师在最近发表的作品中，候选人展示了使用动态电影的可行性。 MRI 用于无创地表征健康受试者和胃功能患者的多个方面在此提案中，候选人寻求应用基于 MRI 的工具来比较其影响。不同穴位刺激对FD患者脑干神经回路及胃动力的影响以及治疗和预期操纵之间的相互作用。本研究的具体目标是1）评估经皮脑干神经回路电穴位刺激（TEAS）在FD中的作用；2）比较腿部（穴位ST36）与腹部的效果；（穴位 ST25）TEAS 对 FD 胃动力的影响；3）评估预期操纵对进餐的影响；作为该提案的一个组成部分，候选人的职业生涯。发展将通过参与高级课程来补充，以发展安慰剂方面的专业知识研究、综合医学、胃肠病学和临床试验的进行正式的指导委员会，由安慰剂研究、神经胃肠病学、神经影像学、针灸学、和综合医学，将为候选人提供监督、指导和帮助，以实现她的目标研究环境，包括 Spaulding 康复医院、Athinoula A. 马蒂诺斯生物医学影像中心、综合疼痛神经影像中心 (CiPNI)、胃肠科、麻省总医院神经肠道健康中心以及哈佛医学院将提供丰富、协作和智力刺激的氛围可确保候选人取得成功。获奖后，候选人将成为一名独立调查员，为我们的理解做出贡献脑肠机制支持肠脑相互作用障碍患者的穴位特异性效应。