A mechanistic and dyadic approach to identify how interpersonal conscientiousness supports cognitive health and lowers risk of dementia

采用机械和二元方法来确定人际责任感如何支持认知健康并降低痴呆风险

• 批准号: 10739837
• 负责人: Angelina R Sutin
• 金额: $ 230.02万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10739837
• 关键词: Achievement; Address; Adult; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Behavior; Behavioral; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Complex; Couples; Dementia; Diabetes Mellitus; Discipline; Disease Progression; Ecological momentary assessment; Environment; Etiology; Family; Genetic; Goals; Health; Healthcare Systems; Hypertension; Impaired cognition; Impairment; Individual; Inflammation; Intervention; Interviewer; Knowledge; Life; Life Cycle Stages; Literature; Loneliness; Longevity; Measures; Mental Depression; Modeling; National Institute on Aging; Nerve Degeneration; Obesity; Onset of illness; Outcome; Pathway interactions; Personal Satisfaction; Personality Traits; Physical activity; Physiological; Prevalence; Prevention; Prevention strategy; Process; Psychological Factors; Public Health; Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sampling; Self-control as a personality trait; Services; Sleep; Smoking; Stress; Testing; Theoretical model; Time; Well in self; Work; cognitive function; cognitive performance; cognitive task; critical period; dementia risk; discounting; effective intervention; healthy aging; human old age (65+); member; middle age; novel; prevent; protective effect; protective factors; psychologic; recruit; satisfaction; therapy development; trait

Project Summary The burden of Alzheimer’s Disease (AD) takes a significant toll on the individual living with dementia, their families and communities, and the healthcare system. Without effective intervention and prevention strategies, the prevalence of AD is expected to more than double over the next 30 years. It is critical to identify protective factors that can be leveraged for more effective prevention before the onset of the disease. Conscientiousness is a personality trait that is associated consistently with better health outcomes, which extends to dementia: Conscientiousness is one of the most replicated psychological factors that is protective against cognitive impairment. Most work on Conscientiousness has focused on its agentic aspects (e.g., self-control, achievement striving). Conscientiousness, however, has a distinct interpersonal component that is often overlooked in the relation with health in general and cognition in particular. This interpersonal component – Interpersonal Conscientiousness – defined as either responsibility or dutifulness, is protective against dementia, an effect that has replicated in three independent samples. In addition, its protective association with dementia is independent of the agentic components of this trait and extends to cognitive function prior to dementia. Interpersonal Conscientiousness is thus a robust and novel psychological factor that is a promising target of intervention for healthier cognitive outcomes in older adulthood. The objective of this proposal is to provide much needed stage 0 evidence that is necessary for intervention development. Specifically, this research aims to identify the clinical/physiological, behavioral, psychological, and relational mechanisms through which Interpersonal Conscientiousness leads to better cognitive outcomes. The proposed research addresses these mechanisms and cognition as typically measured in lab settings and the daily expression of these mechanisms and momentary cognitive performance measured with ecological momentary assessment in everyday life. It seeks to identify the pathways through which Interpersonal Conscientiousness protects cognition and promotes better daily cognitive function across a critical period of the lifespan – midlife and the transition to old age (ages 40-70) – a period particularly relevant for prevention because it is generally before the onset of neurodegeneration. In addition, this research addresses actor and partner effects within committed relationships to test whether the protective effect of Interpersonal Conscientiousness extends from one member of the couple to the other. This work will lead to new knowledge on how Interpersonal Conscientiousness promotes healthier cognitive aging and will point to new prevention and intervention targets for promoting healthier cognitive aging across adulthood to support better outcomes in older adulthood.

项目概要 阿尔茨海默病 (AD) 的负担给痴呆症患者带来了巨大的损失，他们的 如果没有有效的干预和预防策略，家庭和社区以及医疗保健系统， AD 的患病率预计在未来 30 年将增加一倍以上，识别保护措施至关重要。 在疾病发生之前可以利用这些因素进行更有效的预防。 是一种始终与更好的健康结果相关的人格特质，也延伸到痴呆症： 责任心是最常见的心理因素之一，可以防止认知 大多数关于尽责性的工作都集中在其代理方面（例如，自我控制、成就）。 然而，责任心具有独特的人际交往成分，但在人际关系中却经常被忽视。 与一般健康尤其是认知的关系。 责任心——定义为责任或义务，可以预防痴呆症，这种作用 已在三个独立样本中复制。此外，它与痴呆症的保护性关联是独立的。 该特征的代理成分并延伸到痴呆之前的认知功能。 因此，责任心是一种强大而新颖的心理因素，是有希望的干预目标 该提案的目的是为老年人提供更健康的认知结果。 0 干预措施开发所需的证据 具体而言，本研究旨在确定 人际关系的临床/生理、行为、心理和关系机制 认真负责可以带来更好的认知结果。拟议的研究解决了这些机制。 和认知通常在实验室环境中测量以及这些机制的日常表达和 通过日常生活中的生态瞬时评估来测量瞬时认知表现。 确定人际责任心保护认知并促进更好的途径 生命周期关键时期——中年和老年过渡期（40-70 岁）的日常认知功能 – 与预防特别相关的时期，因为它通常是在神经变性发作之前。 此外，本研究还致力于测试参与者和合作伙伴的影响是否 人际责任感的保护作用从夫妻中的一个成员延伸到另一个成员。 这项工作将带来关于人际责任感如何促进更健康的认知衰老的新知识 并将指出新的预防和干预目标，以促进整个成年期更健康的认知衰老 支持老年期取得更好的结果。