Prenatal and Early Life Antecedents of Personality: An Intergenerational Lifespan Approach

人格的产前和早期生命前因：代际寿命方法

• 批准号: 9912678
• 负责人: Angelina R Sutin
• 金额: $ 66.71万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912678
• 关键词: Address; Adolescence; Adult; Age; Aging; Alcohol abuse; Alzheimer' s Disease; Alzheimer' s disease risk; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Buffers; Cardiovascular Diseases; Child; Childhood; Clinical; Cognition; Cognitive; Cognitive aging; Conceptions; Consequentialism; Crime; Data; Data Collection; Data Sources; Development; Disease; Early Intervention; Economics; Environment; Environmental Risk Factor; Exposure to; Functional disorder; Genetic; Gestational Diabetes; Goals; Health; Health behavior; Hypertension; Impaired cognition; Individual; Individual Differences; Inflammation; Informal Social Control; Intervention; Knowledge; Life; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Maternal Health; Measures; Mediating; Mediator of activation protein; Mental Depression; Modeling; Neighborhoods; Neurotic Disorders; Outcome; Outcomes Research; Parents; Pathway interactions; Personal Satisfaction; Personality; Personality Development; Personality Traits; Play; Pregnancy; Process; Research; Risk; Risk Factors; Role; Shapes; Smoking; Temperament; Testing; Theoretical model; Time; Work; base; cognitive development; cognitive function; cohort; disorder risk; early childhood; early life adversity; emotion regulation; fetal programming; healthy aging; improved; inflammatory marker; intergenerational; offspring; prenatal; psychologic; racial diversity; social deprivation; social health determinants; socioeconomics; theories; trait; young adult

Project Summary. This research takes an intergenerational lifespan perspective to the development of trait psychological functioning. There are well-documented connections between Conscientiousness and Neuroticism and aging- related outcomes: Individuals who score higher in Conscientiousness and lower in Neuroticism have lower risk of Alzheimer’s disease and greater longevity. The association between these traits and better health begins early in life and persist across the lifespan. Early interventions to promote healthier trait development will lead to broad improvements in health and well-being and ultimately better aging outcomes. Yet, little is known about the early environmental origins of these traits that would be promising targets of intervention. Likewise, relatively little is known about how biological factors contribute to trait development across the lifespan. The present research brings together three established longitudinal studies of well-characterized cohorts to identify prenatal and childhood environmental factors (broadly construed) that contribute to the development of personality, the biological mediators of these associations, and the dynamics between prenatal/childhood factors and personality on a consequential health outcome – the development and aging of cognitive functioning across the lifespan. Together, these three cohorts cover conception through older adulthood: The Longitudinal Study of Australian Children covers pregnancy through age 12, the Avon Longitudinal Study of Parents and Children covers pregnancy through young adulthood, and the Healthy Aging in Neighborhoods of Diversity across the Life Span covers middle through older adulthood. This research addresses three specific aims: (1) To identify maternal prenatal behavioral and clinical antecedents of temperament and personality traits and to test biological markers as one mechanism through which prenatal factors contribute to trait psychological functioning, (2) To identify childhood neighborhood antecedents of trait psychological functioning in childhood, adolescence, and adulthood and to test biological markers as one mechanism through which neighborhood factors contribute to trait psychological functioning, and (3) To test whether personality traits mediate and/or moderate the relation between the prenatal/childhood environment and cognitive functioning across the lifespan. The outcomes of this research will lead to new knowledge on the origins of the traits most relevant for healthy aging and suggest promising new targets for intervention.

项目摘要。 本研究从代际寿命的角度来看待特质心理的发展 尽责性和神经质与衰老之间存在着充分的联系。 相关结果：责任心得分较高且神经质得分较低的个体风险较低 阿尔茨海默病和更长的寿命这些特征与更好的健康之间的联系开始了。 生命早期并持续一生的早期干预将促进更健康的特质发展。 然而，人们对健康和福祉的广泛改善以及最终更好的老龄化结果知之甚少。 这些特征的早期环境起源将成为有希望的干预目标。 关于生物因素如何影响整个生命周期的性状发展，人们知之甚少。 目前的研究汇集了三项针对特征明确的队列的既定纵向研究，以确定 有助于发育的产前和儿童期环境因素（广义解释） 人格、这些关联的生物调节因素以及产前/儿童期之间的动态 影响健康结果的因素和个性——认知的发展和衰老 这三个群体一起涵盖整个成年期的受孕： 澳大利亚儿童纵向研究涵盖 12 岁之前的怀孕期，雅芳纵向研究 《父母与儿童》涵盖了从怀孕到成年的整个过程，以及社区的健康老龄化。 整个生命周期的多样性涵盖了中老年。这项研究涉及三个特定的问题。 目的：(1) 识别母亲的产前行为以及气质和人格的临床前因 性状并测试生物标记作为产前因素促成性状的一种机制 心理功能，(2) 识别心理功能特质的童年邻里前因 在儿童期、青春期和成年期，并测试生物标记作为一种机制 邻里因素有助于特质心理功能，以及（3）测试人格是否具有特质 调解和/或调节产前/儿童环境与认知功能之间的关系 这项研究的结果将带来关于大多数特征起源的新知识。 与健康老龄化相关，并提出有希望的新干预目标。