US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)

美国-尼日利亚癌症控制实施科学与公平研究中心 (C3-RISE)

基本信息

批准号：
10738439
负责人：
OLIVER CHUKWUJEKWU EZECHI
金额：
$ 104.59万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-19 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10738439
关键词：
Acceleration Address Adoption Affect Africa Apical Applications Grants Attention Award Birth Cancer Burden Cancer Control Cancer Vaccines Cessation of life Consolidated Framework for Implementation Research Country Coupled Decentralization Dose Educational Activities Environment Equity Evaluation Evidence based intervention Faculty Goals Grant Guidelines Health Hepatitis B Hepatitis B Vaccination Hepatitis B Vaccines Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Incidence Infrastructure Institution Intervention Learning Malignant Neoplasms Malignant Vaginal Neoplasm Malignant neoplasm of cervix uteri Malignant neoplasm of liver Malignant neoplasm of penis Malignant neoplasm of vulva Medical Research Mentors Mentorship Mission Modeling Monitor National Institute of Mental Health Newborn Infant Nigeria Nigerian North Carolina Phase Policies Principal Investigator Process Productivity Research Research Personnel Research Project Grants Resource-limited setting Resources Science Services Students System Testing Training Training Programs Translations Travel United States National Institutes of Health Universities Vaccination Vaccines Vision aged anticancer research apprenticeship cancer prevention career community based participatory research community engagement community setting crowdsourcing design direct application evidence base girls health equity health inequalities implementation evaluation implementation facilitators implementation outcomes implementation science implementation strategy improved innovation low and middle-income countries malignant mouth neoplasm mortality multidisciplinary novel outreach prevent public health relevance research and development research study scale up skills success symposium tool uptake vaccine acceptance

项目摘要

ABSTRACT Nigeria has a substantial number of preventable cancer deaths each year. The human papillomavirus (HPV) vaccine and hepatitis B (HBV) vaccine are both evidence-based strategies to prevent cancer, but they have not been widely scaled up in Nigeria. This suggests the need for innovative strategies that leverage implementation science and tap the collective wisdom of Nigeria, Africa’s most populous country. We propose the “US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE).” Our overall mission is two part: (a) use participatory implementation science strategies (i.e. crowdsourcing open calls and apprenticeships) to expand uptake of HPV and HBV vaccines for cancer prevention; and (b) serve as a hub for equity and capacity building in implementation science to advance the understanding of intervention uptake and sustainment of evidence-based interventions to prevent cancer. This project brings together an exceptional group of multi-disciplinary researchers from the Nigerian Institute of Medical Research (the apex federal health research organization, similar to the US NIH), St. Louis University, and the University of North Carolina at Chapel Hill. We propose the following aims: (1) To accelerate equitable cancer control by developing, testing, and refining participatory implementation strategies to decentralize vaccines to prevent cancer in community settings; (2) To enhance the scientific productivity of C3-RISE by providing overarching operational and scientific oversight; (3) To support innovative research and the development of scholars trained to accelerate the uptake and sustainment of evidence-based cancer control interventions in Nigeria. These aims will be accomplished by a nurturing hub of two cores (Administrative, Capacity Building) alongside two research studies (Study 1 focused on HPV vaccination, Study 2 on HBV vaccination). Our three partner institutions launched a participatory implementation science project four years ago that directly informed national Nigerian health guidelines, trained 231 students, provided mentorship opportunities to 43 faculty, and culminated in a WHO/TDR practical guide on crowdsourcing for health (UH3HD096929). This led to a recently awarded NCI R01 grant (R01-CA271033) that uses participatory implementation science to develop innovative strategies to enhance HPV services in Nigeria. C3-RISE will leverage this momentum to catalyze cutting-edge cancer research, training, community engagement, and policy translation. Our project will increase health equity, and it aligns with the Nigerian National Cancer Control Plan by focusing on participation, capacity building, and sustainment. This U54 grant application directly responds to NIH, NCI, and NIMH strategic priorities.

抽象的尼日利亚每年有大量可预防的癌症死亡病例是由人乳头瘤病毒 (HPV) 造成的。疫苗和乙型肝炎 (HBV) 疫苗都是预防癌症的循证策略，但它们并没有已在尼日利亚广泛推广，这表明需要利用创新战略。我们建议，实施科学并发挥非洲人口最多国家尼日利亚的集体智慧。 “美国-尼日利亚癌症控制实施科学与公平研究中心 (C3-RISE)”。总体任务分为两部分：(a) 使用参与式实施科学策略（即众包、开放招募和学徒）以扩大 HPV 和 HBV 疫苗的使用，以预防癌症；以及 (b) 实施科学的公平和能力建设中心，以增进对干预的理解该项目汇集了预防癌症的循证干预措施。来自尼日利亚医学研究所（顶点）的杰出多学科研究人员团队联邦健康研究组织（类似于美国NIH）、圣路易斯大学和北方大学卡罗莱纳州教堂山分校提出以下目标： (1) 通过以下方式加速公平的癌症控制：制定、测试和完善参与性实施战略，以分散疫苗预防社区环境中的癌症；(2) 通过提供总体性方案来提高 C3-RISE 的科学生产力；业务和科学监督；（3）支持创新研究和学者的发展；接受培训，以加速尼日利亚循证癌症控制干预措施的采用和维持。这些目标将通过两个核心（行政、能力建设）以及两项研究（研究 1 关注 HPV 疫苗接种，研究 2 关注 HBV 疫苗接种）。四年前，各机构启动了一个参与性实施科学项目，直接向尼日利亚国家健康指南，培训了 231 名学生，为 43 名教师提供了指导机会，最终形成了 WHO/TDR 关于健康众包的实用指南 (UH3HD096929)。荣获 NCI R01 拨款 (R01-CA271033)，利用参与式实施科学来开发创新加强尼日利亚 HPV 服务的战略将利用这一势头来推动尖端技术的发展。我们的项目将促进癌症研究、培训、社区参与和政策转化。公平，并且它与尼日利亚国家癌症控制计划保持一致，注重参与、能力该 U54 拨款申请直接响应 NIH、NCI 和 NIMH 战略。优先事项。