Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

阿尔茨海默病病理生理学博士前和博士后培训

基本信息

批准号：
10627752
负责人：
Rakez Kayed
金额：
$ 34.91万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10627752
关键词：
Alzheimer&apos s Disease Functional disorder post-doctoral training pre-doctoral

项目摘要

Project Summary/Abstract We proposed creating a highly collaborative pre- and post-doctoral training program in the pathophysiology of Alzheimer’s disease and other related neoconservative disorders. Our program is dedicated on advancing pre- and post-doctoral fellows into independent research scientists at research intensive universities and health- related research laboratories. Our trainees will be mentored by members of the Mitchell Center for Neurodegenerative Diseases at the University of Texas Medical Branch – Galveston. Our highly collaborative faculty reach across multiple departments allowing them to employ a number of experimental approaches to the problems associated with Alzheimer's disease. Our training program incorporates cellular animal models, disease progression mechanisms and pharmacological manipulations, immunotherapeutic approaches targeting tau and amyloid oligomers, synaptic electrophysiology and, DNA damage and repair in neurodegeneration, genetics of synaptic development and degeneration, molecular mechanisms in cognitive resilience, and metabolic determinants of neurodegeneration. A strength of our training program is the investment UTMB has made in developing this highly collaborative team as demonstrated by our joint publications and funded grants. Our four pre-and three post-doctoral trainees will be closely mentored throughout their training. Our pre-doctoral trainees will be required to take several new courses devoted to the cellular signaling in neurodegeneration and the biochemistry and biophysics of amyloid proteins, while our post-doctoral trainees will participate in a certificate program in advanced biomedical research strategies. All trainees will participate in seminars, community building events, journal clubs and active collaborative research training. We have proposed a framework that will enable us to train and mentor both pre- and post-doctoral trainees on their way to becoming independent scientist to help address the Alzheimer’s medical needs of the country.

项目概要/摘要我们建议在病理生理学领域创建一个高度协作的博士前和博士后培训项目我们的计划致力于推进预防阿尔茨海默病和其他相关的新保守性疾病。和博士后研究员成为研究密集型大学和卫生部门的独立研究科学家我们的学员将接受米切尔中心成员的指导。德克萨斯大学加尔维斯顿医学分部的神经退行性疾病我们的高度合作。教师跨多个部门，使他们能够采用多种实验方法来研究我们的培训计划结合了细胞动物模型，疾病进展机制和药理学操作、免疫治疗靶向方法 tau 和淀粉样蛋白寡聚体、突触电生理学以及神经退行性变中的 DNA 损伤和修复，突触发育和退化的遗传学、认知弹性的分子机制，以及我们培训计划的一个优势是 UTMB 的投资。正如我们的联合出版物和资助的赠款所证明的那样，我们在发展这个高度协作的团队方面取得了巨大的成就。我们的四名博士前培训生和三名博士后培训生将在整个培训过程中得到密切指导。学员将被要求参加几门专门研究神经退行性变和细胞信号传导的新课程淀粉样蛋白的生物化学和生物物理学，而我们的博士后学员将参加高级生物医学研究策略证书课程所有学员都将参加研讨会，我们提出了社区建设活动、期刊俱乐部和积极的合作研究培训。框架将使我们能够培训和指导博士前和博士后学员，使他们成为独立科学家帮助解决该国阿尔茨海默氏症的医疗需求。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.

多态性 α-突触核蛋白寡聚物：使用新型相应抗体进行表征和差异检测。

DOI：
发表时间：
2023-05
期刊：
影响因子：
5.1
作者：
Moore, Kenya;Sengupta, Urmi;Puangmalai, Nicha;Bhatt, Nemil;Kayed, Rakez
通讯作者：
Kayed, Rakez

Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.

淀粉样蛋白 β、Tau 和 α-突触核蛋白在神经退行性疾病的发病机制、预后和治疗中聚集。

DOI：
发表时间：
2022-07
期刊：
影响因子：
6.7
作者：
Sengupta, Urmi;Kayed, Rakez
通讯作者：
Kayed, Rakez

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.

Tau 寡聚体诱导的 HMGB1 释放有助于细胞衰老和与阿尔茨海默病和额颞叶痴呆相关的神经病理学。

DOI：
10.1016/j.celrep.2021.109419
发表时间：
2021-07-20
期刊：
Cell reports
影响因子：
8.8
作者：
Gaikwad S;Puangmalai N;Bittar A;Montalbano M;Garcia S;McAllen S;Bhatt N;Sonawane M;Sengupta U;Kayed R
通讯作者：
Kayed R

Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies.

阿尔茨海默病、进行性核上性麻痹和路易体痴呆中神经元、星形胶质细胞和小胶质细胞的病理 tau 特征和核改变。