Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis

针对帕塔纳托细胞焦亡调节坏死途径的辐射缓解剂

• 批准号: 10625932
• 负责人: Hülya Bayir
• 金额: $ 10万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-08 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625932
• 关键词: Acute; Antibodies; Antigens; Apoptosis; Apoptotic; Bacteria; Blood; CASP1 gene; Cell Death; Cell Membrane Permeability; Cell Nucleus; Cell membrane; Cells; Cessation of life; Chemotactic Factors; Computer Models; Data; Development; Disease; Dose; Effectiveness; Epithelial Cells; Event; Exposure to; Free Radicals; Funding; Generations; Goals; Hematopoietic; IL18 gene; In Vitro; Infection; Inflammasome; Inflammatory; Inflammatory Response; Interleukin-1 Receptors; Interleukin-1 beta; Interleukin-18; Intestines; Ionizing radiation; Knowledge; Link; Lipids; Mediating; Medical; Mitochondria; Mitochondrial Proteins; Molecular; Necrosis; Nuclear Radiology; Nuclear Translocation; Nuclear Warfare; Outer Mitochondrial Membrane; Oxidation-Reduction; Oxides; Participant; Pathogenesis; Pathogenicity; Pathway interactions; Phospholipids; Poly(ADP-ribose) Polymerases; Production; Proliferating; Proteins; Radiation; Radiation Accidents; Radiation Injuries; Radiation exposure; Radioactive; Reactive Oxygen Species; Recovery; Role; Signal Pathway; Signal Transduction; Stream; Stress; Structure-Activity Relationship; Syndrome; Testing; Therapeutic; Tissues; Water; Whole-Body Irradiation; anakinra; apoptosis inducing factor; base; clinically translatable; cytokine; design; effectiveness evaluation; gastrointestinal epithelium; improved; in vivo Model; inhibitor; interest; irradiation; lipid biosynthesis; lipid mediator; lipidomics; novel; novel therapeutics; oxidation; pathogen; programs; radiation mitigation; radiation mitigator; radiological attack; response; small molecule inhibitor; trafficking

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