Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis

针对帕塔纳托细胞焦亡的调节性坏死途径的辐射缓解剂

• 批准号: 10838232
• 负责人: Hülya Bayir
• 金额: $ 48.07万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-08 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10838232
• 关键词: Accidents; Acute; Antibodies; Antigens; Apoptosis; Apoptotic; Bacteria; Blood; CASP1 gene; Cell Death; Cell Membrane Permeability; Cell Nucleus; Cell membrane; Cessation of life; Chemotactic Factors; Computer Models; Data; Development; Disease; Dose; Effectiveness; Epithelial Cells; Event; Exposure to; Free Radicals; Funding; Generations; Goals; IL18 gene; In Vitro; Infection; Inflammasome; Inflammatory; Inflammatory Response; Interleukin-1 Receptors; Interleukin-1 beta; Intestines; Ionizing radiation; Knowledge; Link; Lipids; Mediating; Medical; Mitochondria; Mitochondrial Proteins; Molecular; Necrosis; Nuclear; Nuclear Translocation; Nuclear Warfare; Outer Mitochondrial Membrane; Oxidation-Reduction; Participant; Pathogenesis; Pathogenicity; Pathway interactions; Phospholipids; Poly(ADP-ribose) Polymerase Inhibitor; Poly(ADP-ribose) Polymerases; Production; Proteins; Radiation; Radiation Injuries; Radiation exposure; Radioactive; Radiology Specialty; Reactive Oxygen Species; Recovery; Role; Signal Pathway; Signal Transduction; Stream; Stress; Structure-Activity Relationship; Syndrome; Testing; Therapeutic; Tissues; Water; Whole-Body Irradiation; anakinra; apoptosis inducing factor; bone marrow hyperplasia; clinical translation; cytokine; design; effectiveness evaluation; gastrointestinal epithelium; improved; in vivo Model; inhibitor; interest; irradiation; lipid biosynthesis; lipid mediator; lipidomics; novel; novel therapeutics; oxidation; pathogen; programs; radiation mitigation; radiation mitigator; radiological attack; response; small molecule inhibitor; trafficking

No abstract provided

没有提供摘要