REPOSITORY PULL FOR COLLABORATIVE PERINATAL PROJECT (CPP) OBESITY GENOME WIDE ASSOCIATION STUDIES (GWAS)

围产期合作项目 (CPP) 肥胖全基因组关联研究 (GWAS) 的存储库拉取

• 批准号: 10637456
• 负责人: BRITTANY MARTIN
• 金额: $ 9.33万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-20 至 2026-04-19
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10637456
• 关键词: 7 year old; Address; Adult; African; African American; Age; American; Biological; Birth; Blood specimen; Body mass index; Cardiometabolic Disease; Child; Childhood; Collection; Complex; Contracts; Data; Enrollment; Environment; Etiology; European; Food Energy; Genetic; Genetic Predisposition to Disease; Growth; Health; Heritability; Life Style; Link; Medical center; Minnesota; Monitor; Neonatal; Obesity; Obesity Epidemic; Pattern; Perinatal; Phenotype; Population; Pregnancy; Prenatal care; Records; Reporting; Residual state; Sampling; Shipping; Specimen; Time; Umbilical Cord Blood; United States; Universities; Woman; cardiometabolism; cohort; early childhood; early pregnancy; food consumption; genome wide association study; genomic locus; improved; infancy; lifestyle factors; novel; obesity in children; obesogenic; offspring; physical inactivity; prevent; prospective; repository

Obesity is a complex multi-factorial condition that results from genetic predisposition and lifestyle factors such as high energy food consumption and physical inactivity. The heritability of childhood BMI has been estimated to be 40-70%. The high heritability of obesity in the context of the current obesogenic environment strongly suggests that genetic factors are implicated in population patterns of obesity and, as we propose here, are essential to consider in population approaches to address the obesity epidemic. Identifying genetic factors that influence early childhood BMI can inform the etiology of obesity as well as help to identify strategies to prevent and treat childhood obesity and related adult cardiometabolic diseases. Currently, the genetic factors that influence early childhood BMI are not well understood. Genome-wide association studies (GWAS) could help identify these genetic factors and distinguish their effects across ages. The Collaborative Perinatal Project (CPP) was a prospective pregnancy cohort that enrolled women who had prenatal care at 12 medical centers in the United States from 1959-1965. Women were followed from early pregnancy onwards and their offspring were monitored from birth through 7 years of age. While the CPP enrolled children prior to the obesity epidemic and obesogenic lifestyle in the United States, any potential interactions between genetic factors discovered using this cohort and recent environmental modifiers can be validated using other more recent cohorts. The CPP offers opportunities to discover novel genetic loci related to obesity among Africans and Europeans and to improve the functional characterization of known loci discovered in European populations.

肥胖是一种复杂的多因素病症，由遗传倾向和生活方式因素（例如高能量食物消耗和缺乏身体活动）引起。儿童BMI的遗传力估计为40-70%。在当前致肥环境的背景下，肥胖的高遗传性强烈表明，遗传因素与肥胖的人群模式有关，正如我们在此提出的，在解决肥胖流行问题的人群方法中必须考虑遗传因素。 识别影响儿童早期体重指数的遗传因素可以了解肥胖的病因，并有助于确定预防和治疗儿童肥胖和相关成人心脏代谢疾病的策略。目前，影响幼儿期体重指数的遗传因素尚不清楚。全基因组关联研究（GWAS）可以帮助识别这些遗传因素并区分它们在不同年龄段的影响。 围产期合作项目 (CPP) 是一个前瞻性妊娠队列，招募了 1959 年至 1965 年间在美国 12 个医疗中心接受过产前护理的女性。妇女从怀孕早期开始就受到追踪，她们的后代从出生到 7 岁都受到监测。虽然 CPP 在美国肥胖流行和肥胖生活方式之前就招募了儿童，但使用该队列发现的遗传因素与最近的环境调节剂之间的任何潜在相互作用都可以使用其他更新的队列进行验证。 CPP 提供了在非洲人和欧洲人中发现与肥胖相关的新基因位点并改善在欧洲人群中发现的已知基因位点的功能特征的机会。