NICHD HUMAN BIOSPECIMEN REPOSITORY - RHODE ISLAND CHILDRENS HEALTH EQUITY AND DEVELOPMENT STUDY (ENRICHED) REPOSITORY

NICHD 人类生物样本存储库 - 罗德岛州儿童健康公平与发展研究（丰富）存储库

• 批准号: 10710575
• 负责人: BRITTANY MARTIN
• 金额: $ 41.52万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-29 至 2026-09-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710575
• 关键词: Adult; Bar Codes; Beginning of Life; Biological; Biological Assay; Biological Specimen Banks; Blood; Blood specimen; Cheek structure; Child Development; Child Health; Chronic Disease; Collection; DNA analysis; Development; Discrimination; Disease; Economically Deprived Population; Ensure; Epigenetic Process; Equipment and supply inventories; Erythrocytes; Fathers; Gene Expression Profiling; Generations; Genetic; Gestational Diabetes; Hair; Health behavior; Human; Hydrocortisone; Immune; Infant; Interview; Lead; Life; Life Expectancy; Link; Low Birth Weight Infant; Measures; Mediating; Mental Depression; Mental Health; Metabolic; Metabolic Marker; Minority; Mothers; National Institute of Child Health and Human Development; Neurosecretory Systems; Online Systems; Parents; Persons; Phenotype; Plasma; Play; Poverty; Pregnancy; Premature Birth; Process; Psychopathology; Rhode Island; Role; Saliva; Salivary; Sampling; Services; Specimen; Swab; System; Testing; Time; Tube; Umbilical Cord Blood; United States; Urine; Ursidae Family; Visit; Weight Gain; disadvantaged population; early childhood; environmental chemical; experience; follow-up; health disparity; health equity; high risk; low socioeconomic status; maternal risk; obstetric outcomes; offspring; postnatal; prenatal; repository; social disadvantage; socioeconomics; stress reactivity; transmission process; web-accessible

Early life conditions including poverty and discrimination generate health disparities throughout life that become further entrenched in disadvantaged populations through transmission across generations. In the United States, these disparities manifest in differences in life expectancy and chronic disease and have their origins early in life; as early as the prenatal period. Adults of low socioeconomic status and particularly minorities experience disproportionately high rates of psychopathology, including depression, which bears well-documented associations with preterm delivery and other adverse obstetric outcomes. Parental mental health, which is strongly linked with social and economic disadvantage as well as differences in child development, may play a key mediating role in the transmission of disparities across generations but previous studies have not fully considered paternal as well as maternal psychopathology. As a result, though disparities in health are well documented, the developmental mechanisms that impact disparities at the very beginning of life are not, particularly those which lead to developmental deficits that emerge long before presentation of disease. The aims of the Rhode Island Children’s Health Equity and Development Study (ENRICHED) are to test the hypotheses that low socioeconomic and minority status results in higher risk of parental psychopathology, gestational neuroendocrine and metabolic dysregulation, and poor health-related behaviors in both parents and offspring. Biological samples will be collected from mothers throughout the duration of the study. Maternal blood samples will be used to measure a panel of neuroendocrine-immune and metabolic markers. These metabolites have been related to maternal risk of gestational diabetes, low birth weight, and rapid postnatal weight gain, suggesting that metabolite profiles of maternal samples pre-delivery are useful in characterizing maternal pregnancy metabolic status, and can predict infant neurodevelopmental phenotypes in early childhood. Blood will also be used to facilitate genetic, epigenetic, and gene expression analyses. Maternal urine will be used for assaying the concentration of environmental chemicals. Around the time of delivery, cord blood will also be collected and processed. Cord blood will be used to assess neuroendocrine-immune and metabolic markers and to facilitate genetic, epigenetic, and gene expression analyses. Biological fathers will contribute a single blood sample at the time of their in-person interview. Paternal blood will be used to facilitate genetic, epigenetic, and gene expression analyses. If fathers do not wish to allow blood collection, cheek swabs will be requested for salivary DNA analyses. Infants will have hair collected at both follow-up visits to assess cortisol as an indicator of HPA functioning / stress reactivity.

包括贫困和歧视在内的早期生活状况造成了整个社会的健康差距 通过跨界传播，弱势群体的生活变得更加根深蒂固 在美国，这些差异表现为预期寿命和年龄的差异。 慢性疾病起源于生命早期； 失业状况，特别是少数族裔的失业率过高 精神病理学，包括抑郁症，有充分证据表明抑郁症与早产有关 分娩和其他不良产科结果密切相关。 由于社会和经济劣势以及儿童发展的差异，可能发挥关键作用 在代际差异传递中发挥中介作用，但之前的研究并未发现 因此，尽管存在差异，但充分考虑了父亲和母亲的精神病理学。 健康状况有据可查，影响差异的发展机制 生命之初并非如此，尤其是那些导致长期出现发育缺陷的人 在出现疾病之前。 罗德岛州儿童健康公平与发展研究 (ENRICHED) 的目的是检验以下假设：社会经济地位低和少数族裔地位导致父母生育风险较高。 精神病理学、妊娠神经内分泌和代谢失调以及与健康状况不佳相关的 父母和子女的行为。 在整个研究期间，将从母亲身上收集生物样本。 血液样本将用于测量一组神经内分泌免疫和代谢标记物。 这些代谢物与母亲患妊娠期糖尿病、低出生体重和妊娠期糖尿病的风险有关。 出生后体重快速增加，表明分娩前母体样本的代谢特征有助于表征母体妊娠代谢状态，并且可以预测儿童早期的婴儿神经发育表型。血液也将用于促进遗传、 表观遗传学和基因表达分析将用于测定环境化学物质的浓度。 在分娩时，还将收集并处理脐带血。 用于评估神经内分泌免疫和代谢标记物，并促进遗传、表观遗传、 和基因表达分析。 亲生父亲将在面谈时提供一份血样。 父亲的血液将用于促进父亲的遗传、表观遗传和基因表达分析。 如果不想采集血液，则需要使用脸颊拭子进行唾液 DNA 分析。 在两次随访中都会收集婴儿的头发，以评估皮质醇作为 HPA 的指标 功能/应激反应。