Administrative Core

行政核心

基本信息

批准号：
10621322
负责人：
Ignacio E. Sanz
金额：
$ 10.18万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-25 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10621322
关键词：
Accounting Accreditation Alabama American Animals B-Lymphocytes Budgets COVID-19 vaccination Cellular biology Certification Clinical Clinical Trials Communication Communities Complex Conflict of Interest Data Deposition Disclosure Disease Enrollment Ensure Epigenetic Process Expenditure Feedback Financial Support Funding Future General Population Goals Grant Guidelines Health Human Human Resources Immunologist Immunology Inflammation Information Dissemination Infrastructure Institution Institutional Review Boards International Investigation Joints Laboratories Laboratory Personnel Leadership Manuscripts Monitor Occupational activity of managing finances Oral Patient Recruitments Personnel Recruitments Plasma Cells Policies Process Productivity Progress Reports Protocols documentation Publications Regulation Reporting Research Research Personnel Research Subjects Resources Rheumatology Rotation Safety Science Structure Students System Training United States National Institutes of Health Universities Update Work Workplace animal care animal safety college data sharing design experience meetings member operation organizational structure patient safety plasma cell development programs recruit repository sample collection skills success symposium synergism timeline transcriptomics

项目摘要

ADMINISTRATIVE CORE A ABSTRACT. Coordinated leadership through a strong administrative structure is an essential component of the success of complex multiple-laboratory projects. This is particularly true for projects involving human research as there are additional recruitment, safety, and regulatory concerns that must be met. The purpose of Core A is to facilitate progress of the projects of the PPG in understanding the processes that underly plasma cell development and its dysregulation in disease. To accomplish this objective, we will continue to build and refine the infrastructure that we have been developing over the previous 5 years for the administration of this PPG. The function of Core A will continue to be to provide administrative support, organization, coordination and efficient management of this PPG with the overarching goal of ensuring the scientific productivity of all projects. Core A will be directed by Dr. Iñaki Sanz (overall P.I., and Project 4 Leader), who in addition to being a world class expert on human B cell biology, has also accumulated substantial experience in directing multi-investigator research programs over the past 20 years. He will be assisted by two recruited expert staff members; Dr. Amy Stout who has extensive experience providing administrative and financial support and overseeing multi-center projects at Emory University and Ms. Sang Le who has 15 years experience overseeing specimen collection programs and enabling large clinical trials within the Emory IRB system. Through administrative oversight and guidance, we will ensure proper and timely fiscal management and efficient use of human and financial resources. Core A will make sure that all staff and support personnel are trained and accredited for safety, Institutional Review Board, and institutional animal care and use purposes. Core A will also track study enrollment and provide a continuing review of enrollment to PIs to ensure overall patient recruitment goals and timelines are being met. The Core will continue to provide scientific coordination and interaction through structured monthly, quarterly, and yearly meetings, and will monitor project progress and assist PIs with annual progress reports. Oversight will additionally be provided by an established External Advisory Board of accomplished immunologists with extensive relevant expertise in B cell biology, tolerance, inflammation and epigenetics. Core A will facilitate interactions between PPG leadership and the External Advisory Board through planning and execution of a yearly meeting designed to provide project updates, discuss ongoing and future studies, and obtain objective feedback on the overall status of the program. The core will also ensure timely dissemination of results and data sharing though project presentation and publication targets. By streamlining and consolidating administrative task and providing strategic leadership and internal and external coordination, Core A will enable the project PIs to collaboratively produce rigorous and impactful scientific findings that increase our understanding of plasma cells and positively influence human health. 1

行政核心摘要。通过强有力的行政结构进行协调领导是成功的重要组成部分对于涉及人类研究的复杂的多实验室项目尤其如此。必须满足的额外招聘、安全和监管问题核心 A 的目的是促进。 PPG 在了解浆细胞发育过程和为了实现这一目标，我们将继续建设和完善基础设施。我们在过去 5 年中一直在为 PPG 的管理而制定。 A将继续提供行政支持、组织、协调和高效管理该 PPG 的总体目标是确保所有项目的科学生产力。核心 A 将由 Iñaki Sanz 博士（总体 P.I. 和项目 4 负责人）指导，他也是一名世界级专家人类B细胞生物学一流专家，在指导多位研究者方面也积累了丰富的经验他将得到两名专家招募的工作人员的协助； Stout 在提供行政和财务支持以及监督多中心方面拥有丰富的经验埃默里大学的项目和拥有 15 年监督标本采集经验的 Sang Le 女士通过行政监督和支持，在埃默里 IRB 系统内开展大型临床试验。指导意见，确保财政管理得当、及时，人力财力有效利用资源。核心 A 将确保所有员工和支持人员均接受安全、机构方面的培训和认证审查委员会和机构动物护理和使用目的核心 A 还将跟踪研究注册和使用目的。持续审查 PI 的招募情况，以确保总体患者招募目标和时间表核心将继续通过结构化的月度会议提供科学的协调和互动。季度和年度会议，并将监控项目进度并协助 PI 编写年度进度报告。此外，由资深免疫学家组成的外部顾问委员会还将提供监督拥有 B 细胞生物学、耐受性、炎症和表观遗传学方面的相关广泛专业知识将促进这一过程。 PPG 领导层与外部顾问委员会之间通过规划和执行年度会议旨在提供项目最新情况，讨论正在进行的和未来的研究，并获得目标该核心还将确保及时传播结果和数据。通过简化和整合行政管理来共享项目演示和发布目标。任务并提供战略领导和内部和外部协调，核心 A 将支持项目 PI 合作产生严格且有影响力的科学发现，增加我们对等离子体的理解细胞并对人类健康产生积极影响。 1