Training Grant In Radiation Biology

放射生物学培训补助金

• 批准号: 8868947
• 负责人: MICHAEL L. FREEMAN
• 金额: $ 6.95万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2016-04-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8868947
• 关键词: Grant; Radiobiology; Training

DESCRIPTION (provided by applicant): The American Cancer Association estimates that 1.5 million citizens of the US are diagnosed with cancer each year. Approximately 50% of these cancer patients will undergo radiation therapy, which can provide definitive local regional tumor control, thus affording these patients with a durable progression free survival. Unfortunately, many tumors do not respond to irradiation. Elucidating the molecular mechanisms responsible for radiation therapy's failure to control tumor growth requires a critical understanding of Radiation Biology, a multi- disciplinary science that studies physics, biology, and medicine as it pertains to oncogenesis, tumor biology and normal tissue physiology. As important as Radiation Biology is for supporting Radiation Oncology's mission, there are very few such training programs in this country. The goal of this training grant is to continue to teach Postdoctoral Fellows to perform independent research in the area of Radiation Biology, so that they can make outstanding contributions to the fields of Radiation Oncology and Cancer Biology. We propose to accomplish this using a multi-faceted approach consisting of 1) training in the laboratories of outstanding scientists who utilize cutting edge techniques coupled with highly collaborative approaches, 2) multi- disciplinary seminar series designed to foster interactions between basic scientists and clinician/scientists who perform translational research, 3) didactic training in the areas of Radiation Biology, Radiation Physics, and Cancer Biology, 4) a grant writing workshop, 5) professional development, 6) training in laboratory management, and 7) Training in the Responsible Conduct of Research. Trainees must have completed a MD and/or a PhD prior to entering the program. The program is designed to train 3 Fellows for a duration ranging from 2 to 3 years. It is anticipated that 2 of the trainees will have just completed their PhD or MD and the third trainee will have 2 or 3 years Post Doctoral experience prior to entering our program. To date 70% of trainees who complete training tenure track assistant professors, staff scientists at pharmaceutical companies, or Radiation Oncology Residents on track to attain faculty positions. Of note, 30% of the trainees who have accepted offers to this program have been underrepresented minorities. Based on these successes, we submit that this training grant program is fulfilling the goals of the National Ruth L. Kirschstein National Research Service Award.

描述（由申请人提供）：美国癌症协会估计，每年有150万美国公民被诊断出患有癌症。这些癌症患者中约有50％将接受放射治疗，这可以提供明确的局部区域肿瘤控制，从而为这些患者提供持久的无进展生存率。不幸的是，许多肿瘤对辐照没有反应。阐明负责放射治疗无法控制肿瘤生长的分子机制需要对辐射生物学有批判性了解，这是一种与肿瘤生成，肿瘤生物学和正常组织生理学有关的物理，生物学和医学研究的多学科科学。与辐射生物学有关，对于支持辐射肿瘤学的使命，该国很少有这样的培训计划。这项培训补助金的目的是继续教授博士后研究员在放射生物学领域进行独立研究，以便他们可以为放射肿瘤学和癌症生物学领域做出杰出的贡献。我们建议使用多方面的方法来实现这一目标，包括1）在杰出科学家的实验室中进行培训，他们利用尖端技术的实验室，加上高度协作的方法以及高度协作的方法，2）多学科研讨会系列，旨在促进基础科学家与临床科学家之间的基础科学家和临床科学家之间的相互作用，他们在转换式研究中进行转换培训，4）一项癌症培训，3）一项癌症培训，3）散热性培训，散热性生物学，散热性生物学，散热性生物学，散热性生物学，散热性生物学，散热性生物学，散热性培训研讨会，5）专业发展，6）实验室管理培训，以及7）负责任进行研究的培训。 在输入计划之前，学员必须完成MD和/或博士学位。该计划旨在训练3名研究员，持续时间为2至3年。可以预计，有2名学员将刚刚完成博士学位或医学博士学位，而第三名学员将在进入我们的计划之前拥有2或3年的博士学位经验。迄今为止，有70％的受训者完成了培训任期助理教授，制药公司的员工科学家或辐射肿瘤学的居民，旨在担任教师职位。值得注意的是，接受该计划的要约的学员中有30％的人数不足。基于这些成功，我们认为该培训赠款计划正在实现国家露丝·柯希斯坦国家研究服务奖的目标。