Wireless EEG System for Training Attention and Eye Movement in ASD

用于训练自闭症患者注意力和眼动的无线脑电图系统

• 批准号: 9134199
• 负责人: JEANNE TOWNSEND
• 金额: $ 24.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134199
• 关键词: Address; Adult; Affect; Age; Attention; Autistic Disorder; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Behavioral Symptoms; Brain; Child; Clinical; Clinical Trials; Communication; Computer software; Conduct Clinical Trials; Development; Devices; Disease; Early Intervention; Effectiveness of Interventions; Electroencephalography; Elements; Environment; Evaluation; Eye; Eye Movements; Feedback; Foundations; Goals; Goggles; Helmet; Home environment; Intervention; Language; Learning; Life; Link; Measures; Methods; Monitor; Motor; Motor Skills; Nature; Outcome; Outcome Measure; Performance; Phase; Pre-Post Tests; Questionnaires; Saccades; Sampling; Sensory; Series; Shapes; Social Environment; Social Functioning; Social Interaction; Social support; Speed; Symptoms; System; Tablet Computer; Teenagers; Testing; Time; Training; Video Games; Visual; Visual attention; Wireless Technology; Work; aged; associated symptom; auditory feedback; autism spectrum disorder; base; behavior test; course development; design; flexibility; follow-up; improved; light weight; new technology; novel; persistent symptom; programs; response; skills; social; social communication; social skills; targeted treatment; virtual reality; visual feedback; visual motor

DESCRIPTION (provided by applicant): Autism Spectrum Disorder (ASD) is a lifelong disorder that severely affects the ability to learn and function in a social environment. In typica function, higher level social, language and communication skills develop over the first few years of life and depend upon the critical building blocks of sensory-motor and attention abilities. Similarly in autism, higher level problems with social communication develop over the first two post- natal years and are preceded by subtle but abnormal visual attention and motor skills. Trainings to improve social interaction and communication are the most common of behavioral interventions in ASD. These therapies may improve the specific behaviors that are targets of the training, but rarely do they generalize to broader function or other clinical symptoms. We propose that interventions aimed instead at the early deficits that support social and language skills would be more broadly effective. Because disruption of attention is one of the earliest and most persistent symptoms in autism, and because attention is highly subject to improvement with training, it is an important target for intervention. We propose a novel intervention to trai the speed and accuracy of attention orienting and eye movement. The training is designed to target attentional behaviors that have been shown to be impaired in autism, including attention orienting, disengagement and shifting, and a restricted attentional field. Because eye movement and attention are tightly linked, eye movement deficits in ASD parallel those found in spatial attention. Eye movements provide a marker for attention and the proposed training is designed to improve speed, accuracy and flexibility of eye movement and attention simultaneously. Training will use a series of entertaining video games to gradually shape behavior using visual and auditory feedback provided in real time from wireless EEG mounted in lightweight headgear designed for home use. We plan three levels of outcome measures for pre- and post-training to test the effectiveness of the intervention (direct tests of attention and eye movement; tests of improvement in attentional and visual monitoring and speed and accuracy of response in a simulated environment; tests of behavior in an actual social environment). During the R21 phase of this application we will: complete and test hardware and software; validate EEG and eye-tracking methods; test feasibility of the system for use at home; design, program and pilot test the video games. During the R33 phase of this project we will conduct clinical trials with control conditions (e.g., standard video games without training elements) with a small sample of ASD children aged 9-15. If this initial work is successful, the long term goal would be to develop a readily available inexpensive EEG-based system for home use that is suitable for a broad age range of ASD children and adults.

描述（由申请人提供）：自闭症谱系障碍（ASD）是一种终身疾病，严重影响在社交环境中学习和功能的能力。在Typica功能中，更高级别的社交，语言和沟通能力在生命的最初几年发展，并取决于感官运动和注意力能力的关键构建。同样，在自闭症中，社交沟通的更高级别的问题在前两个后几年都会发展出来，并且在视觉上的微妙但异常的视觉注意力和运动技能之前。改善社会互动和沟通的培训是ASD行为干预中最常见的。这些疗法可能会改善训练目标的特定行为，但很少会推广到更广泛的功能或其他临床症状。我们建议针对支持社会和语言技能的早期赤字的干预措施将更加广泛。由于注意力的破坏是自闭症中最早，最持久的症状之一，并且由于训练的注意力高度改善，因此它是干预的重要目标。 我们提出了一种新颖的干预措施，以提高注意力和眼动的速度和准确性。该培训的目的是针对自闭症患者受损的注意行为，包括注意力导向，脱离和转移以及受限制的注意领域。由于眼动和注意力紧密相连，因此在空间注意力中发现的ASD的眼睛运动缺陷。眼动为注意力提供了标记，拟议的训练旨在同时提高眼动和注意力的速度，准确性和灵活性。培训将使用一系列有趣的视频游戏来逐步塑造行为，并实时实时提供的视觉和听觉反馈，该无线脑电图安装在设计用于家庭使用的轻质头饰中。我们计划进行三个级别的结局指标，以测试干预措施的有效性（注意力和眼动的直接测试；在模拟环境中的注意力和视觉监测以及响应速度的改善以及在实际社交环境中的行为测试）。在此应用程序的R21阶段，我们将：完成和测试硬件和软件；验证脑电图和眼睛跟踪方法；测试系统在家使用的可行性；设计，程序和试点测试视频游戏。在该项目的R33阶段，我们将以控制条件（例如，没有培训元素的标准视频游戏）进行临床试验，并以9-15岁的ASD儿童样本样本。如果这项最初的工作是成功的，那么长期的目标是开发一种易于使用的基于EEG的廉价住房系统，该系统适用于广泛的ASD儿童和成人。