What is Endometriosis? Deep Phenotyping to Advance Diagnosis and Treatment

什么是子宫内膜异位症？

基本信息

批准号：
10622684
负责人：
Asgerally T. Fazleabas
金额：
$ 4.87万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10622684
关键词：
Adolescent Adult Affect Age Award Blood Characteristics Classification Clinical Complement Data Diagnosis Doctor of Philosophy Endometrial Female Future Gland Health Heterogeneity Intervention Medical Records Mentors Methods Operative Surgical Procedures Outcome Pain Pain Threshold Pain-Free Parents Participant Pathway interactions Patient Selection Patient Self-Report Patients Persistent pain Phenotype Postoperative Pain Prevalence Prognosis Research Research Support Sampling Selection for Treatments Sensory Staging System Symptoms Testing Time Tissue Sample Universities Urine Uterine cavity Woman central pain central sensitization chronic pain chronic pelvic pain cohort common symptom disease classification disease phenotype doctoral student endometriosis experience new therapeutic target noninvasive diagnosis novel parent grant patient subsets phenomics phenotypic data precision medicine professor psychologic reproductive

项目摘要

Endometriosis is a debilitating and often incurable condition characterized by the presence of endometrial- like glands and stroma thriving outside of the uterine cavity. The condition affects approximately 10–15% of all women of reproductive age. The most common symptom of endometriosis is pain, with endometriosis diagnosed in approximately 83% of all chronic pelvic pain (CPP) cases in the US. Current classification and staging systems for endometriosis have not found clinically useful associations with the level or chronicity of pain. Approximately 30% of women with endometriosis-associated pain (EAP) continue to experience persistent pain after surgery to treat the condition, possibly explained by central sensitization (CS). The parent grant, “What is Endometriosis? Deep Phenotyping to Advance Diagnosis and Treatment (WisE),” (PI: Missmer; R01 HD094842; Project dates 08/01/18 to 04/30/23) aims to identify unique classifications of patients with endometriosis that will inform non-invasive diagnostics, prognosis given current treatments, and novel treatment pathways. This Research Supplement to Promote Diversity in Health-Related Research application is requested to formally add Ms. Claire Lunde to the WisE team and support her research time during her final nine months as a doctoral student at the University of Oxford. The proposed mentoring team also includes Professor Vincent and Dr. Sieberg; both are Co-Is on the parent award and are Ms. Lunde’s current Ph.D. supervisors. As the parent R01 aims to discover informative subtypes of endometriosis and disease classifications, the candidate will supplement this research by analyzing existing sensory data (n=108) conducted on the same sample to further subdivide endometriosis participants by low and high CS. The most relevant aims of the parent award are Aims 3 and 4, which entail characterizing disease phenotypes by symptom presentation and heterogeneity of phenomics data for patients with endometriosis. The parent R01 uses harmonized medical records, participant data, blood, urine, and tissue samples for a diverse cohort of adolescents and adult females (n~2600). Integrating Quantitative Sensory Testing and phenomics data will further identify differences in functional pain characteristics between endometriosis participants and pain- free controls and provide a comprehensive set of objective patient phenotypes complementing the rich self- reported phenotype data. These results will elucidate the pain profiles in the clinical presentations (including pain thresholds and psychological variables) and if there is an association with outcomes after interventions (e.g., surgery). This will also allow for defining strategies for patient selection for future trials of novel therapeutics targeting these mechanisms. This critical research will expand upon our current collaborative research by enhancing our understanding of the impact of centralized pain on patients with endometriosis through establishing characteristics of patient subgroups using a mixed-method approach.

子宫内膜异位症是一种使人衰弱且通常无法治愈的疾病，其特征是存在子宫内膜异位症。例如在子宫腔外生长的腺体和间质，这种情况影响了大约 10-15% 的女性。所有育龄妇女子宫内膜异位症最常见的症状是疼痛。在美国，大约 83% 的慢性盆腔疼痛 (CPP) 病例被诊断为当前的分类和。子宫内膜异位症的分期系统尚未发现与子宫内膜异位症的水平或慢性程度有临床上有用的关联。大约 30% 患有子宫内膜异位症相关疼痛 (EAP) 的女性持续经历疼痛。手术治疗后出现持续性疼痛，可能是由于中枢敏化（CS）所致。补助金，“什么是子宫内膜异位症的深度表型分析以促进诊断和治疗（WisE）”（PI： Missmer；R01 HD094842；项目日期为 08/01/23 至 04/30/23）旨在确定子宫内膜异位症患者将为非侵入性诊断、当前治疗的预后提供信息，以及本研究补充旨在促进健康相关研究的多样性。申请正式将 Claire Lunde 女士加入 WisE 团队并支持她的研究时间在她作为牛津大学博士生的最后九个月期间，拟议的导师团队。还包括 Vincent 教授和 Sieberg 博士；两人都是家长奖的共同获奖者，也是 Lunde 女士的获奖者作为当前的博士生导师，R01 的目标是发现子宫内膜异位症的信息亚型。疾病分类，候选人将通过分析现有的感官数据来补充这项研究 (n=108) 对同一样本进行了进一步按低和高 CS 细分子宫内膜异位症。家长奖最相关的目标是目标 3 和 4，它们需要表征疾病表型通过子宫内膜异位症患者的症状表现和表型组学数据的异质性。 R01 使用统一的医疗记录、参与者数据、血液、尿液和组织样本来处理不同的队列青少年和成年女性 (n~2600) 整合定量感官测试和表型组学数据。将进一步确定子宫内膜异位症和疼痛之间功能性疼痛特征的差异自由控制并提供一套全面的客观患者表型，补充丰富的自我报告的表型数据将阐明临床表现中的疼痛特征（包括疼痛阈值和心理变量）以及是否与干预后的结果存在关联（例如，手术）。这也将允许为未来的新试验定义患者选择策略。针对这些机制的治疗方法将扩展我们目前的合作。通过增强我们对集中疼痛对子宫内膜异位症患者影响的了解来进行研究通过使用混合方法确定患者亚组的特征。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Trends in pelvic pain symptoms over 2 years of follow-up among adolescents and young adults with and without endometriosis.

患有或不患有子宫内膜异位症的青少年和年轻人在两年的随访中骨盆疼痛症状的趋势。

DOI：
发表时间：
2023-03-01
期刊：
影响因子：
7.4
作者：
Sasamoto, Naoko;Shafrir, Amy L;Wallace, Britani M;Vitonis, Allison F;Fraer, Cameron J;Sadler Gallagher, Jenny;DePari, Mary;Ghiasi, Marzieh;Laufer, Marc R;Sieberg, Christine B;DiVasta, Amy D;Schrepf, Andrew;As;Terry, Kathryn L;M
通讯作者：
M

Epidemiology of Adenomyosis.

子宫腺肌病的流行病学。

DOI：
发表时间：
2020-05
期刊：
影响因子：
2.7
作者：
Upson, Kristen;Missmer, Stacey A
通讯作者：
Missmer, Stacey A

Chronic pelvic pain: importance of compatible clinical trial outcomes.

慢性盆腔疼痛：相容的临床试验结果的重要性。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Shafrir; A L
通讯作者：
A L

Differences in characteristics and use of complementary and alternative methods for coping with endometriosis-associated acyclic pelvic pain across adolescence and adulthood.

青春期和成年期应对子宫内膜异位症相关非周期性盆腔疼痛的特征和补充和替代方法的使用差异。

DOI：
发表时间：
2023
期刊：
影响因子：
0
作者：
Mongiovi, Jennifer M;Wallace, Britani;Goodwin, McKenzie;Vitonis, Allison F;Karevicius, Sarah;Shafrir, Amy L;Sasamoto, Naoko;DiVasta, Amy D;Sieberg, Christine B;Terry, Kathryn L;Missmer, Stacey A
通讯作者：
Missmer, Stacey A

Peripheral Blood Leukocyte Telomere Length and Endometriosis.

外周血白细胞端粒长度和子宫内膜异位症。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Sasamoto, Naoko;Yland, Jennifer;Vitonis, Allison F;Cramer, Daniel W;Titus, Linda J;De Vivo, Immaculata;Missmer, Stacey A;Terry, Kathryn L
通讯作者：
Terry, Kathryn L