Mentoring Imaging Research in Early AD

指导早期 AD 的影像学研究

• 批准号: 9032789
• 负责人: REISA A. SPERLING
• 金额: $ 13.24万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9032789
• 关键词: Accounting; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Amyloid; Atrophic; Award; Biology; Biometry; Brain Diseases; Clinical; Clinical Investigator; Clinical Research; Clinical Trials Design; Cognition; Cognitive; Cognitive aging; Collaborations; Data; Dementia; Development; Disease; Disease Marker; Disease Progression; Doctor of Medicine; Early Intervention; Educational process of instructing; Educational workshop; Evaluation; Faculty; Female; Fostering; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Funding Applicant; Gender; Genotype; Goals; Grant; Hippocampus (Brain); Image; Imaging Device; Imaging Techniques; Impaired cognition; Incidence; Individual; Institutes; Knowledge; Lead; Leadership; Longitudinal Studies; Manuscripts; Massachusetts; Measures; Memory; Memory Loss; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority; Modality; Nerve Degeneration; Neurologist; Pathology; Phenotype; Positron-Emission Tomography; Prevention trial; Public Health Schools; Publishing; Research; Research Personnel; Research Project Grants; Risk; Secondary Prevention; Sex Characteristics; Staging; Symptoms; Technology; Time; Training; United States National Institutes of Health; Woman; Work; Writing; abeta accumulation; abeta deposition; aging brain; amyloid imaging; base; bioimaging; brain volume; career; career development; catalyst; cerebrovascular; cognitive neuroscience; cognitive performance; effective therapy; gender difference; high risk; imaging biomarker; improved; in vivo; insight; interdisciplinary approach; interest; male; medical schools; molecular imaging; multimodality; neuroimaging; neuropsychological; next generation; novel; patient oriented; patient oriented research; pre-clinical; prevent; programs; public health relevance; relating to nervous system; sex; skills; symptomatology; synaptic function; tau Proteins

 DESCRIPTION (provided by applicant): This is an application for a one-time renewal of K24 Midcareer Investigator Award in aging and Alzheimer's disease (AD) patient-oriented research. The candidate, Reisa A. Sperling, M.D. M.MSc., is a neurologist with a strong track record as a productive clinical investigator and research mentor. The overarching aims of the candidates' research program are to: 1) elucidate the neural underpinnings of memory decline in aging and early AD; 2) develop sensitive imaging markers to track the progression of early AD; and 3) facilitate earlier intervention with potential disease-modifying treatments in the preclinical stags of AD. The candidate currently leads several ongoing NIH and foundation-funded multimodality imaging projects in aging, preclinical, and prodromal AD, as well as a large secondary prevention trial in preclinical AD. The candidate will continue to use her funded research as a platform for the mentorship of young patient-oriented investigators, and to promote a multidisciplinary approach to the study of cognitive aging and early AD. The candidates' mentees have the opportunity to train in functional, structural, and molecular imaging techniques, cognitive neuroscience, neuropsychological assessment, biostatistics, and clinical trial design as they apply to aging and early AD research, drawing on expertise from an outstanding group of collaborators. Trainees will also be able to participate in research seminars, statistical courses and imaging workshops, career development and grant- writing workshops provided by Harvard Catalyst CTSC, T32 and other training grants, as well as formal didactic course work through the Catalyst, Harvard Medical School, Harvard School of Public Health, and Massachusetts Institute of Technology. A new component proposed for the K24 renewal is "mentoring on mentoring" to teach developing investigators how to effectively mentor their own mentees as they transition to independence. The candidate has successfully mentored more than 20 fellow and junior faculty trainees over the past 5 years of the initial K24 award, including multiple women and several minority young researchers, who have published over 60 manuscripts and have garnered multiple honors and funding for their work. The K24 renewal research project proposes to investigate the influence of sex (gender) on AD imaging biomarkers and risk of cognitive decline, which will provide many new research opportunities for the candidate's mentees. To further her own continued professional development through the K24 mechanism, the candidate will acquire training in sex-based biology and advanced analytic methodology, and will continue to enhance her mentoring skills through formal mentoring and leadership training. This K24 renewal is critically important for the candidate to continue to grow and foster her clinical research career development and, most essentially, to protect her time to mentor the next generation of investigators committed to early AD patient-oriented research.

 描述（由应用程序提供）：这是申请K24衰老和阿尔茨海默氏病（AD）患者研究的K24中级研究员奖。候选人Reisa A. Sperling，M.D。M.Msc。是一名神经科医生，作为一名富有生产力的临床研究者和研究精神，具有很强的记录。候选人研究计划的总体目的是：1）阐明衰老和早期AD的记忆下降的神经元基础； 2）开发敏感的成像标记以跟踪早期AD的进展； 3）在AD的临床前雄鹿中促进早期干预。该候选人目前领导着几项正在进行的NIH和基金会资助的多模式成像项目，用于衰老，临床前和前驱AD，以及临床前AD中的大型二级预防试验。候选人将继续利用她的资助研究作为年轻面向患者研究人员心态的平台，并促进一种多学科方法来研究认知衰老和早期AD。候选人的门口有机会培训功能，结构和分子成像技术，认知神经科学，神经心理学评估，生物统计学和临床​​试验设计，因为它们适用于衰老和早期的AD研究，从而利用了一群出色的合作者的专业知识。受训人员还将能够参加研究半级别的课程，统计课程和成像研讨会，职业发展和赠款写作研讨会，由哈佛大学Catalyst CTSC，T32和其他培训赠款以及通过催化剂，哈佛医学院，哈佛大学，公共卫生学院以及马萨诸塞州的技术学院进行的正式教学课程。为K24更新提出的一个新组成部分是“指导心理化”，以教发展研究人员如何在过渡到独立性时如何有效指导自己的导师。在最初的K24奖的过去5年中，该候选人已成功指导了20多名研究员和初级教师学员，其中包括多名女性和几位少数年轻研究人员，他们出版了60多名手稿，并为其工作获得了多个荣誉和资金。 K24更新研究项目的提案旨在调查性别（性别）对AD成像的影响和认知能力下降的风险，这将为候选人的Mendees提供许多新的研究机会。为了通过K24机制来进一步持续的专业发展，候选人将获得基于性别的生物学和高级分析方法的培训，并将继续通过正式的心理和领导培训来增强她的心理技能。此K24更新对于候选人的门date至关重要 并促进了她的临床研究职业发展，最重要的是，为了保护她的时间，即致力于早期以患者为导向的研究的下一代研究人员。