Core B: Administrative and Data Management Core

核心 B：行政和数据管理核心

• 批准号: 10612361
• 负责人: MICHAEL M. SHEN
• 金额: $ 25.36万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612361
• 关键词: Abate; Area; Bass; Biometry; Budgets; Cancer Center; Cells; Collaborations; Communication; Communities; Complex; Dana-Farber Cancer Institute; Data; Ensure; Equity; Evaluation; Feedback; Fostering; Future; Genetically Engineered Mouse; Genomics; Health; Human Resources; Individual; Infrastructure; Institution; Laboratories; Laboratory Personnel; Leadership; Malignant neoplasm of prostate; Medical center; Medicine; Memorial Sloan-Kettering Cancer Center; Mission; Modeling; Molecular Analysis; Monitor; Mouse Strains; Office of Administrative Management; Oregon; Organization administrative structures; Organoids; Participant; Pharmacologic Substance; Preparation; Program Reviews; Progress Reports; Research; Research Personnel; Resolution; Resource Sharing; Resources; Science; Scientist; Structure; The Jackson Laboratory; Time; Universities; conflict resolution; data management; data sharing; experience; genomic data; laboratory experiment; meetings; member; operation; programs; recruit; single cell sequencing; success; synergism

Project Summary/Abstract The Administrative and Data Management Core will provide coordination and oversight of all activities of the Projects and Cores in this Program, and will maximize interactions and potential synergies among Project Leaders, Core Leaders, and laboratory personnel at the three participating institutions: Columbia University Irving Medical Center (CUIMC), Memorial Sloan Kettering Cancer Center (MSKCC), and Weill Cornell Medicine (WCM). The major scientific functions of the Core will be to provide expert support for data management, biostatistics, and resource sharing for the Projects and Core A. In addition, to facilitate program integration and effective communication among its various members, the Core will organize monthly meetings composed of two parts: (i) Research presentations, which will include all program participants, as well as relevant Internal Advisory Board members; and (ii) Executive meetings, which will be limited to the Executive Committee (Drs. Shen, Abate- Shen, Sawyers, and Loda) and members of the Internal Advisory Board. The latter meetings will provide a forum for candid assessment of research progress, oversight of Core utilization, prioritization of resources and objectives, and resolution of potential conflicts. In addition, the Data Management component will organize monthly meetings of the computational biologists on all Projects and Core A to ensure effective integration of single-cell sequencing data. An important function of the Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and regulatory compliance. Finally, the Core will organize an annual full-day review of the Program Project by members of the Internal and External Advisory Boards, who will provide detailed feedback on research progress and future directions, as well as advice on program management. This Core will have the following specific aims: (1) Data management for the Projects and Core A, which will be led by co-Investigator, Dr. Aristidis Floratos (CUIMC); (2) Biostatistical support for the Projects and Core A, which will be led by Dr. Glen Heller (MSKCC); and (3) Program management, which will include: (a) Coordination of the overall program by maintaining the organization of the program and establishing mechanisms for effective interaction among its personnel; (b) Data and resource sharing by promoting effective utilization of Core A, and by facilitating data and resource sharing with external laboratories, including access to complex mouse strains through the Jackson Laboratory; (c) Review of the Program Project by Internal and External Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions. Taken together, the operations of the Administrative and Data Management Core will ensure the smooth and efficient functioning of the overall Program, as well as planning and oversight for its operations, and will promote the sharing of data and resources within the Program Project as well as with external investigators.

项目概要/摘要 行政和数据管理核心将为所有活动提供协调和监督 该计划中的项目和核心，并将最大限度地发挥项目之间的互动和潜在协同作用 三所参与院校领导、核心领导及实验室人员： 哥伦比亚大学 欧文医疗中心 (CUIMC)、纪念斯隆凯特琳癌症中心 (MSKCC) 和威尔康奈尔医学中心 （WCM）。核心的主要科学功能是为数据管理提供专家支持， 生物统计学以及项目和核心 A 的资源共享。此外，为了促进计划整合和 各成员之间进行有效的沟通，核心将每月组织一次会议，由两名成员组成 部分： (i) 研究报告，其中包括所有计划参与者以及相关的内部咨询 董事会成员； (ii) 执行会议，仅限于执行委员会（沉博士，Abate- Shen、Sawyers 和 Loda）以及内部顾问委员会成员。后面的会议将提供一个论坛 坦诚评估研究进展、监督核心利用、确定资源优先顺序和 目标和潜在冲突的解决。此外，数据管理组件将组织 计算生物学家每月就所有项目和核心 A 举行会议，以确保有效整合 单细胞测序数据。核心的一项重要职能是通过以下方式提供后勤支持： 数据和资源管理、财务审查和预算分析、进度报告的准备，以及 监管合规性。最后，核心将组织对计划项目进行年度全天审查， 内部和外部顾问委员会成员，他们将提供有关研究进展的详细反馈 和未来的方向，以及项目管理的建议。 该核心将具有以下具体目标： (1) 项目和核心 A 的数据管理，其中 将由联合研究员 Aristidis Floratos 博士 (CUIMC) 领导； （二）项目和核心的生物统计支持 A，由 Glen Heller 博士 (MSKCC) 领导； (3) 计划管理，其中包括： (a) 通过维护计划的组织和建立机制来协调整个计划 其人员之间的有效互动； (b) 通过促进有效利用数据和资源共享 核心 A，并促进与外部实验室的数据和资源共享，包括访问复杂的 杰克逊实验室的小鼠品系； (c) 内部和外部对计划项目的审查 顾问委员会评估每个项目的持续进展，审查核心的功能，并提供 对未来研究方向的建议。总而言之，行政和数据管理的运作 核心将确保整个计划以及规划和监督的顺利和高效运作 其运营，并将促进计划项目内以及与 外部调查员。