Stereospecific Nickel-Catalyzed Cross-Coupling for Pharmacophore Synthesis

用于药效团合成的立体特异性镍催化交叉偶联

• 批准号: 9128644
• 负责人: Elizabeth Reinhardt Jarvo
• 金额: $ 27.01万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9128644
• 关键词: Address; Alcohols; Antineoplastic Agents; Biological; Biomedical Research; Carbon; Chemicals; Clinical Trials; Complement; Complex; Coupling; Development; Electrons; Ethers; Goals; Knowledge; Lead; Marketing; Methods; Natural Products; Nickel; Organic Synthesis; Organometallic Chemistry; Pharmaceutical Chemistry; Pharmacologic Substance; Positioning Attribute; Preparation; Production; Reaction; Reagent; Research; Synthesis Chemistry; Testing; Therapeutic; Transition Elements; Translating; Tubulin; Work; analog; base; catalyst; chemical reaction; design; pharmacophore; polymerization; prostate cancer cell line; research study; stereochemistry

DESCRIPTION (provided by applicant): This proposal outlines the development of new chemical methods for alkyl-alkyl cross- coupling reactions to form carbon-carbon bonds. The objectives of this project are to generate new strategies for stereospecific cross-coupling reactions, where the stereochemical information from the electrophilic reaction partner is translated to the newly formed stereogenic center of the product. These methods will be utilized in the synthesis of di- and triarylmethane analogs of anticancer agents. The development of these reactions will directly impact the development of new pharmaceutical agents by providing new methods for their preparation.

描述（由申请人提供）：该提案概述了用于烷基-烷基交叉偶联反应以形成碳-碳键的新化学方法的开发。该项目的目标是为立体特异性交叉偶联反应生成新策略，其中来自亲电子反应伙伴的立体化学信息被转化为产物新形成的立体中心。这些方法将用于合成抗癌剂的二芳基甲烷和三芳基甲烷类似物。这些反应的发展将通过提供新的制备方法来直接影响新药物的开发。