Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

立体选择性镍催化偶联和级联反应

• 批准号: 10633198
• 负责人: Elizabeth Reinhardt Jarvo
• 金额: $ 29.22万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633198
• 关键词: Address; Alcohols; Alkanesulfonates; Biological; Chemicals; Chemistry; Clinical Trials; Coupling; Cyclohexanes; Cycloparaffins; Cyclopentane; Development; Ethers; Event; Experimental Designs; Glycols; In Situ; Intercept; Interruption; Iodides; Knowledge; Marketing; Medicine; Mesylates; Methods; Natural Products; Nickel; Organic Synthesis; Organometallic Chemistry; Pharmacologic Substance; Positioning Attribute; Preparation; Production; Reaction; Series; Sulfonamides; Synthesis Chemistry; System; Testing; Therapeutic; Transition Elements; catalyst; chemical reaction; cyclopropane; functional group; stereochemistry

Project Summary/Abstract This proposal outlines the development of new chemical methods for cross-coupling reactions for formation of strained rings and in domino reactions. The objectives of this project are to generate new strategies for stereoselective coupling reactions, including stereospecific and stereoconvergent reactions. Reactions will be triggered such that typically sluggish functional groups, including alkyl alcohol derivatives, will participate. The development of these reactions will directly impact the development of new pharmaceutical agents by providing new strategies for their preparation.

项目概要/摘要 该提案概述了交叉偶联新化学方法的开发 形成应变环的反应和多米诺骨牌反应。本次活动的目标 项目旨在产生立体选择性偶联反应的新策略，包括 立体特异性和立体收敛反应。反应将被触发，使得 通常缓慢的官能团，包括烷基醇衍生物，将参与其中。 这些反应的发展将直接影响新材料的开发。 药物制剂提供新的制备策略。

项目成果

Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents.

• DOI: 10.1021/acs.joc.2c01590
• 发表时间: 2022-09-16
• 期刊: JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 3.6
• 作者: Hirbawi, Nadia;Lin, Patricia C.;Jarvo, Elizabeth R.
• 通讯作者: Jarvo, Elizabeth R.

A Nickel-Catalyzed Cross-Electrophile Coupling Reaction of 1,3-Dimesylates for Alkylcyclopropane Synthesis: Investigation of Stereochemical Outcomes and Radical Lifetimes.

• DOI: 10.1021/acscatal.3c00905
• 发表时间: 2023-04-21
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Chen, Pan-Pan;McGinnis, Tristan M.;Lin, Patricia C.;Hong, Xin;Jarvo, Elizabeth R.
• 通讯作者: Jarvo, Elizabeth R.

Nickel-Catalyzed Stereoselective Coupling Reactions of Benzylic and Alkyl Alcohol Derivatives.

• DOI: 10.1021/acs.accounts.3c00547
• 发表时间: 2023-11-21
• 期刊: ACCOUNTS OF CHEMICAL RESEARCH
• 影响因子: 18.3
• 作者: Herbert, Claire A.;Jarvo, Elizabeth R.
• 通讯作者: Jarvo, Elizabeth R.

Zinc-Mediated Transformation of 1,3-Diols to Cyclopropanes for Late-Stage Modification of Natural Products and Medicinal Agents.

• DOI: 10.1021/acs.orglett.2c02362
• 发表时间: 2022-08-05
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: McGinnis, Tristan M.;Thane, Taylor A.;Jarvo, Elizabeth R.
• 通讯作者: Jarvo, Elizabeth R.

Stereospecific Nickel-Catalyzed Cross-Electrophile Coupling Reaction of Alkyl Mesylates and Allylic Difluorides to Access Enantioenriched Vinyl Fluoride-Substituted Cyclopropanes.

• DOI: 10.1021/acscatal.3c00257
• 发表时间: 2023-04-07
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Lin, Patricia C.;Joshi, Chetan;McGinnis, Tristan M.;Mallojjala, Sharath Chandra;Sanford, Amberly B.;Hirschi, Jennifer S.;Jarvo, Elizabeth R.
• 通讯作者: Jarvo, Elizabeth R.