ABCD-USA Consortium: Twin Research Project

ABCD-美国联盟：双胞胎研究项目

基本信息

批准号：
9150609
负责人：
Marie T Banich
金额：
$ 472.06万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9150609
关键词：
10 year old Address Adolescence Adolescent Adolescent Development Adult Affect Age Alcohol consumption Alcohol or Other Drugs use Behavior Behavioral Behavioral Genetics Biochemical Markers Biological Biological Assay Brain Brain imaging Brain scan Child Clinical Cognitive Colorado Communities Consent Data Data Analyses Demographic Factors Development Dizygotic Twins Drug abuse Drug usage Emotional Enrollment Environment Event Feces Frequencies Functional Magnetic Resonance Imaging Future Genes Genetic Genetic study Genomics Growth Health Hormonal Change Image Individual Informatics Institutes Interview Investigation Life Link Longitudinal Studies Magnetic Resonance Imaging Marijuana Mediating Mental Health Methodology Methods Minnesota Modeling Monitor Motivation Neurobiology Neurocognitive Neuropsychological Tests Nicotine Online Systems Outcome Outcome Measure Participant Pathology Pathway interactions Pattern Phenotype Prevention Process Psyche structure Psychopathology Puberty Public Policy Recruitment Activity Research Research Personnel Research Project Grants Resources Rewards Risk Risk-Taking Saliva Sampling Self-control as a personality trait Serum Site Social Functioning Source Structure Symptoms Techniques Technology Teenagers Testing Time Toxic effect Twin Multiple Birth Universities Urine Virginia Washington Work addiction adolescent substance use aged base behavioral health behavioral outcome cognitive control design early onset substance use endophenotype epigenomics follow-up gene environment interaction genome sequencing gut microbiota innovation interest metabolomics microbiome misuse of prescription only drugs neurocognitive test neuroimaging peer influence physical conditioning psychological outcomes relating to nervous system response temporal measurement trend whole genome

项目摘要

DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from the Twin Hub of the ABCD-USA Consortium is in response to RFA-DA-15-015; the proposal includes the University of Minnesota (hub leader), Virginia Commonwealth University, Washington University, and the University of Colorado to prospectively determine neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 800 twin pairs, ages 9-10 years, from four sites whose researchers are leaders in twin research, SU and abuse, and neuroimaging of cognitive and emotional functioning will be tested, together with 700 singletons, contributing to the sample of 11,111 to be collected from 11 hubs across the ABCD-USA Consortium. Participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) effects of substance use patterns on the adolescent brain; 2) effects of substance use on behavioral and health outcomes; 3) bidirectional relationships between psychopathology and substance use patterns; 4) effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) "gateway interactions" between use of different substances. The Twin Hub proposes to use classic and co-twin control designs to study genetic vs. environmental contributions to adolescent brain/behavioral development and how these contributions predict SU propensity. Using sophisticated growth trajectory modeling techniques, we will also identify the genetic and environmentally- determined consequences of substance use on brain and behavioral development, including the assessment of gene-by-environment interactions. In addition, we will develop biospecimen resources for future studies of genomic, epigenomic, metabolomics and microbiome changes that may influence substance use and its broad health consequences. Specific to this Twin-Hub, we will obtain baseline and follow-up serum, saliva, and in some cases gut microbiota from biological samples. This work enriches the full ABCD-USA Consortium given that disentangling G and E contributions to individual risk for addiction and sensitivity to SU's neurocognitive effects has highly significant public policy and prevention-based implications.

描述（由应用程序提供）：ABCD-USA联盟双枢纽的青少年站点应用程序是对RFA-DA-15-015的响应；该提案包括明尼苏达大学（HUB领导者），弗吉尼亚州联邦大学，华盛顿大学和科罗拉多大学，以确定对儿童和青少年的药物使用的神经发育和行为预测指标和后果。从四个地点，他们的研究人员是双胞胎研究，SU和滥用的领导者以及对认知和情感功能的神经影像学的代表性社区样本，他们的研究人员将与700个Singletons一起进行测试，并为11,111个样本提供了11,111个单独的测试。参与者将接受全面的基线评估，包括最新的脑成像，全面的神经心理学测试，生物测定，移动监测和仔细评估底物使用，环境，精神病理症状以及每2年的社会功能。临时年度访谈和季度基于Web的评估将以最少的参与伯恩（Burnen）提供精致的行为，发展和生活事件的临时解决。在本项目过程中获得的这些联盟范围内的数据将阐明：1）物质使用模式对青少年大脑的影响； 2）物质使用对行为和健康结果的影响； 3）心理病理学与物质使用模式之间的双向关系； 4）个体遗传，行为，神经生物学和环境差异对风险特征和物质使用结果的影响； 5）使用不同物质之间的“网关相互作用”。双重枢纽的提议使用经典和联合双胞胎控制设计来研究对青少年大脑/行为发展的遗传和环境贡献，以及这些贡献如何预测SU的倾向。使用复杂的生长轨迹建模技术，我们还将确定使用物质对大脑和行为发展的遗传和环境确定的后果，包括评估基因逐环境相互作用。此外，我们还将开发生物循环资源，用于对基因组，表观基因组，代谢组学和微生物组变化的未来研究，这些变化可能会影响药物使用及其广泛的健康后果。特定于该双枢纽，我们将获得基线和随访血清，唾液，在某些情况下，从生物样品中肠道菌群。鉴于对SU成瘾的个人风险和对SU的神经认知效应的敏感性的贡献，这项工作丰富了整个ABCD-USA财团，具有非常重要的公共政策和基于预防的影响。