Metabolomics and Type 2 Diabetes in a Cohort of Older Puerto Ricans

波多黎各老年群体的代谢组学和 2 型糖尿病

• 批准号: 9178206
• 负责人: Shilpa Nandana Bhupathiraju
• 金额: $ 14.95万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178206
• 关键词: Acculturation; Acids; Address; Adult; Advisory Committees; Affect; Amino Acids; Aminoisobutyric Acids; Area; Aromatic Amino Acids; Betaine; Beverages; Biological; Biological Markers; Boston; Case-Control Studies; Cereals; Chemicals; Choline; Chronic Disease; Coffee; Cohort Studies; Complex; Data; Data Set; Development; Diabetes Mellitus; Diet; Dietary Factors; Dietary Practices; Disease; Educational workshop; Ensure; Environment; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Fiber; Functional disorder; Genomics; Glutamates; Glutamine; Health; High Prevalence; Hispanics; Human; Hypertension; Inflammation; Institution; Interdisciplinary Study; K-Series Research Career Programs; Levocarnitine; Life; Life Style; Lipids; Measures; Meat; Medical Research; Mentors; Metabolic; Metabolic syndrome; Mexican Americans; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Organism; Pathway interactions; Phenotype; Plasma; Play; Population; Postdoctoral Fellow; Prevalence; Prevention strategy; Preventive Intervention; Productivity; Proteomics; Public Health; Public Health Schools; Puerto Rican; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Sampling; Schools; Secondary to; Source; Stress; System; Technology; Testing; Training; Work; cardiometabolic risk; career; cohort; design; diabetes risk; experience; gut microbiota; health disparity; high risk; high throughput technology; laboratory experience; meetings; metabolic profile; metabolomics; modifiable risk; novel; novel marker; nutrition; nutritional epidemiology; population based; prevent; programs; prospective; skills; symposium; tool; transcriptomics; trimethyloxamine; urea cycle

PROJECT SUMMARY This 4-year K01 career development award was designed to provide the necessary resources and training to the candidate, Dr. Shilpa N Bhupathiraju, to launch an independent research career in the field of nutrition and chronic disease epidemiology. The training plan includes a mixture of didactic course work, hands-on laboratory training, metabolomics workshops, seminars, advisory committee meetings, career enrichment programs, and attendance at national conferences. It is intended to provide Dr. Bhupathiraju with the necessary skill set in the emerging fields of metabolomics and systems epidemiology. Dr. Bhupathiraju is a highly motivated and capable young researcher with an established record of research productivity in the area of dietary and lifestyle determinants of chronic diseases. However, in order to achieve research independence, she will need to master novel analytic tools in nutritional epidemiology such as systems epidemiology and metabolomics. The proposed project will be implemented at the Harvard T.H. Chan School of Public Health. The school is adjacent to a wide range of research and medical institutions giving Dr. Bhupathiraju access to an enormous range and depth of scientific expertise, resources, and opportunities to advance her career and establish research independence. The proposed project is unique and timely as it is the first ever to evaluate novel and unexplored metabolic biomarkers of type 2 diabetes (T2D) in a group of older Puerto Ricans. Among all Hispanic sub-groups, Puerto Ricans experience the poorest health with excessive prevalence of T2D, metabolic syndrome, hypertension, and obesity. They have unique dietary patterns that may contribute to T2D risk. Stored baseline samples from the Boston Puerto Rican Health Study will be used to measure promising metabolites related to T2D risk, including gut microbiota metabolites, urea cycle metabolites, 2-aminoadipic acid, 2-hydroxybutanoic acid, branched chain and aromatic amino acids, and β-aminoisobutyric acid in an efficient case-control study design of 120 prevalent T2D cases and 120 matched controls. By taking advantage of already measured cardiometabolic biomarkers at baseline and 2-years, the project will also evaluate the cross-sectional and prospective associations between candidate metabolites and intermediate markers of T2D. Secondary to these aims, the candidate will also 1) identify pathways and signatures associated with T2D, and 2) examine dietary sources of key metabolites. The Boston Puerto Rican Health Study is well-suited to examine these research questions as it has stored biospecimens and well-validated measures of diet, lifestyle, and ethnic-specific variables such as acculturation and perceived stress. Findings from the proposed research may help identify novel biomarkers and prevention strategies for T2D. The world-class mentoring team who are leaders in their respective fields together with the rich scientific environment and resources will ensure the successful and seamless transition of Dr. Bhupathiraju into an independent investigator in nutrition, metabolomics, and chronic disease epidemiology.

项目摘要 这项为期4年的K01职业发展奖旨在提供必要的资源和培训 候选人Shilpa n Bhupathiraju博士在营养领域启动独立研究职业 慢性疾病流行病学。培训计划包括教学课程工作，动手的混合 实验室培训，代谢组学研讨会，半小伙子，咨询委员会会议，职业充实 计划和参加全国会议。它旨在为Bhupathiraju博士提供 代谢组学和系统流行病学的新兴领域的必要技能。 Bhupathiraju博士是 具有积极进取和有能力的年轻研究人员，该地区具有既定的研究生产力记录 饮食和生活方式确定慢性疾病。但是，为了实现研究独立性， 她将需要掌握营养流行病学的新颖分析工具，例如系统流行病学和 代谢组学。拟议的项目将在哈佛T.H.实施。陈公共卫生学院。 该学校毗邻各种各样的研究和医疗机构，使Bhupathiraju博士进入 科学专业知识，资源和机会的巨大范围和深度，以推动她的职业生涯和 建立研究独立性。拟议的项目是独一无二的，因为它是有史以来第一个评估的项目 一组老式波多黎各人的2型糖尿病（T2D）的新颖和意外的代谢生物标志物。之中 波多黎各人的所有西班牙裔小组都经历了最差的健康状况，过度患病率是T2D 代谢综合征，高血压和肥胖症。他们具有独特的饮食模式，可能有助于T2D 风险。来自波士顿波多黎各人健康研究的存储的基线样品将用于衡量承诺 与T2D风险有关的代谢产物，包括肠道微生物群代谢物，尿素周期代谢产物，2-氨基磷脂 酸，2-羟基丁酸，分支链和芳香氨基酸以及β-氨基糖酸在A的酸中 有效的病例对照研究设计了120个普遍的T2D病例和120个匹配的对照。利用优势 在基线和2年的已经测量的心脏代谢生物标志物中，该项目还将评估 候选代谢物与T2D的中间标记之间的横截面和前瞻性关联。 其次是这些目标，候选人还将1）确定与T2D相关的途径和签名以及 2）检查关键代谢产物的饮食来源。波士顿波多黎各人健康研究非常适合 研究这些研究问题，因为它已经存储了饮食，生活方式的生物测量和验证良好的措施 以及诸如培养和感知压力之类的民族特定变量。拟议研究的发现 可能有助于确定T2D的新型生物标志物和预防策略。世界一流的指导团队 是各自领域的领导者以及丰富的科学环境和资源将确保 Bhupathiraju博士成功而无缝过渡到营养独立研究者， 代谢组学和慢性疾病流行病学。