Project 2

项目2

基本信息

批准号：
10598937
负责人：
CESALTINA FERREIRA LORENZONI
金额：
$ 33.78万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598937
关键词：
AIDS related cancer Ablation Acetic Acids Address Advanced Development Behavioral Sciences Biomedical Engineering Biopsy Brazil Cancer Etiology Caring Categories Cervical Cancer Screening Cervical dysplasia Characteristics Clinical Cold Therapy Collaborations Country DNA Development Diagnosis Diagnostic Disease Epidemiology Equipment Evaluation Excision Face Fresh Tissue Funding Goals Gynecologic Oncologist Gynecologist HIV HIV Infections HIV Seronegativity HIV/AIDS Hematoxylin and Eosin Staining Method Histologic Histopathology Human Papillomavirus Human Resources Image Infrastructure Institution Lesion Malignant Neoplasms Malignant neoplasm of cervix uteri Measures Mentors Methods Microscope Mozambique Nurses Operative Surgical Procedures Optics Pathologist Pathology Performance Pilot Projects Prevalence Prevention Prevention approach Reagent Research Research Infrastructure Research Personnel Research Project Grants Research Training Resource Sharing Resource-limited setting Risk Risk Factors Slide Specialist Surgical margins Technology Testing Texas Thermal Ablation Therapy Time United States National Institutes of Health Vision Visit Visual Woman cancer invasiveness career cervical biopsy co-infection cohort comorbidity cost diagnostic technologies digital digital healthcare follow-up loop electrosurgical excision procedure low and middle-income countries multidisciplinary new technology novel point of care point-of-care diagnostics premalignant prevent programs prospective psychosocial recruit research study screening program social stigma standard of care tissue processing treatment planning

项目摘要

ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Brazil and Mozambique. The research theme chosen for this U54 HIV-Associated Malignancy Research Center (HAMRC) is to develop novel, low-cost and technologically feasible approaches for cervical cancer screening, diagnosis, and treatment in women living with HIV (WLWH) in low- and middle-income countries (LMICs). This HAMRC will be a collaboration between institutions in the US, Mozambique and Brazil and includes investigators with expertise in HIV/AIDS, Cervical Cancer, Bioengineering, Pathology, Epidemiology and Behavioral Science. The investigators have several ongoing scientific and clinical collaborations which include projects across all three countries. Our proposal addresses the NIH priority: To address HIV-associated comorbidities, coinfections and complications, which includes Malignancies as a category. HIV infection is a known risk factor for cervical cancer, with WLWH having an approximate 6-fold increased risk of developing cervical cancer. The overall goals of the AVANÇO Research Consortium include: 1) Establish sustainable research infrastructure to perform multi-institutional research studies related to HIV-associated malignancies across institutions in the US, Brazil and Mozambique. We will build a comprehensive research program focused on identifying novel, low-cost and technologically feasible approaches for the prevention, diagnosis, and treatment of cervical cancer in WLWH in LMICs. 2) Conduct two Research Projects that advance the development of promising low-cost technologies focused on the diagnoses of high-grade cervical dysplasia and invasive cervical cancer among WLWH. 3) Facilitate and enhance the professional development of junior investigators to conduct HIV- associated malignancy research in Mozambique and Brazil. Through our Developmental Core and Shared Resource Core, we will build research capacity and collaboration through formal research training courses, pilot project funding, and implementation of a Project ECHO® program for research capacity building focused on mentoring and supporting early-career investigators.

抽象的 AVANÇO 研究联盟的总体愿景是建立可持续的基础设施在巴西制定专注于与艾滋病毒相关的恶性肿瘤的研究计划莫桑比克为本次 U54 HIV 相关恶性肿瘤研究选择的研究主题中心（HAMRC）致力于开发新颖、低成本且技术上可行的方法低度和中度艾滋病毒感染者 (WLWH) 妇女的宫颈癌筛查、诊断和治疗该 HAMRC 将是中等收入国家 (LMIC) 各机构之间的合作。美国、莫桑比克和巴西，包括具有艾滋病毒/艾滋病、宫颈疾病专业知识的调查人员癌症、生物工程、病理学、流行病学和行为科学。正在进行多项科学和临床合作，其中包括所有三个领域的项目国家。我们的提案涉及 NIH 的优先事项：解决与 HIV 相关的合并症、合并感染和并发症，其中包括恶性肿瘤这一类别，艾滋病毒感染是已知的危险因素。对于宫颈癌，WLWH 患宫颈癌的风险增加约 6 倍癌症。 AVANÇO 研究联盟的总体目标包括： 1）建立可持续的研究基础设施以进行多机构研究我们在美国、巴西和莫桑比克的机构中开展了与艾滋病毒相关的恶性肿瘤相关的研究。将建立一个全面的研究计划，重点是识别新颖、低成本和预防、诊断和治疗宫颈癌的技术可行的方法中低收入国家 WLWH 中的癌症。 2) 开展两个研究项目，推动有前途的低成本技术的发展专注于诊断高度宫颈不典型增生和侵袭性宫颈病变的技术 WLWH 中的癌症。 3) 促进和加强初级研究者的专业发展，以开展艾滋病毒- 通过我们的发展核心在莫桑比克和巴西进行相关的恶性肿瘤研究。和共享资源核心，我们将通过正式的方式建设研究能力和合作研究培训课程、试点项目资助以及 Project ECHO® 计划的实施用于研究能力建设，重点是指导和支持早期职业研究人员。