Biorepository & Tissue Analysis Shared Resource

生物样本库

基本信息

批准号：
10589897
负责人：
STEVEN L. CARROLL
金额：
$ 5.95万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10589897
关键词：
Address Advanced Malignant Neoplasm African American Animal Model Applications Grants Area Biological Specimen Banks Biology Blood Cancer Center Cancer Center Support Grant Cancer Patient Cells Clinical Clinical Data Clinical Research Clinical Trials Collaborations Conceptions Consent Cooperative Human Tissue Network DNA Department chair Development Doctor of Philosophy Emerging Technologies Ethnic Origin Evaluation Freezing Funding Future Goals Hematologic Neoplasms Histologic Histopathology Human Image Immune Institutional Review Boards Island Laboratories Leadership Link Lipids Malignant Neoplasms Medical Medicine Neurofibromatoses Neurofibromatosis 1 Oncogenes Pathologist Pathology Patients Pattern Play Polysaccharides Population Heterogeneity Positioning Attribute Predisposition Prevention Protein Glycosylation Proteins Protocols documentation Publications Publishing RNA Regimen Research Research Personnel Research Project Grants Research Support Resource Sharing Resources Role Science Sea Services Signal Transduction Solid Neoplasm South Carolina Specimen Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Strategic Planning System Techniques Therapeutic Tissue Donors Tissue Microarray Tissue Model Tissue Stains Tissue imaging Tissues Translational Research Tumor Biology Tumor Tissue Universities Work animal tissue anticancer research autosome biobank cellular imaging clinical diagnosis cost effectiveness data acquisition data repository drug development drug efficacy early onset ethnic diversity experimental analysis falls follow-up histological specimens histological stains human tissue improved insight instrumentation interest lipidomics liquid crystal polymer meetings molecular imaging multiplexed imaging new technology patient derived xenograft model pre-clinical research programs protein expression racial diversity repository research study sugar symposium technology development tumor tumor microenvironment

项目摘要

BIOREPOSITORY & TISSUE ANALYSIS SHARED RESOURCE: SUMMARY The Hollings Cancer Center (HCC) Biorepository & Tissue Analysis (BTA) Shared Resource provides investi- gators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource com- prises several integrated services such as a biospecimen and data repository; customized and readily availa- ble tissue microarrays; RNA and DNA extractions; research pathology services, including histologic analysis of fixed, frozen, and stained tissues; and analysis of experimental results. The BTA partners with the Lipidomics Shared Resource to introduce novel technologies for spatially profiling and imaging proteins, lipids, and gly- cans in patient tumor tissues. By linking histopathology to the characterization of lipid, sugar, and protein ex- pression in tissues of clinical interest, the BTA opens the opportunity for HCC investigators to revolutionize tu- mor tissue analysis and identify previously unrecognized therapeutic avenues. Since 2013, the BTA has collected more than 26,500 cancer-associated biospecimens from patients with solid tumors and hematological malignancies, all of which are annotated and linked to clinical data. A notable fea- ture of the BTA is its ability to tailor the accrual of specimens to meet specific needs of HCC investigators. Cur- rently, 25% of BTA tissue donors are African American patients, who are typically underrepresented in biore- positories and in cancer research. During the current funding period, the BTA supported the research of 49 HCC investigators, resulting in 30 publications and 20 funded grant applications. The BTA has made impactful contributions to advance cancer research at HCC, including the identification of specimens from underserved patients with Sea Island ancestry and the use of MALDI imaging to study protein glycosylation patterns in can- cer. In addition to serving a growing group of HCC investigators, the BTA contributes to major national biore- pository efforts, including the NCI-funded Patient-Derived Xenograft (PDX) Repository, the NCI-funded Coop- erative Human Tissue Network, and the DOD-funded multi-center NCORP Racially and Ethnically Diverse Early Onset Repository. Under the leadership of Steven L. Carroll, MD, PhD, an expert in the autosomal domi- nant tumor susceptibility syndrome neurofibromatosis type 1, the BTA has become an ethnically rich and di- verse tumor tissue biorepository that serves as an important scientific resource for HCC investigators inter- ested in linking basic biology findings to the prevention, clinical diagnosis, and treatment of human cancer.

生物样本库和组织分析共享资源：摘要霍林斯癌症中心 (HCC) 生物样本库和组织分析 (BTA) 共享资源提供研究鳄鱼能够接触到精心收集和注释的人类标本以及先进的人类和需要最先进的仪器和专业知识的动物组织分析。共享资源com- 提供多项综合服务，例如生物样本和数据存储库；定制且易于使用 ble组织微阵列； RNA 和 DNA 提取；研究病理学服务，包括组织学分析固定、冷冻和染色的组织；并分析实验结果。 BTA 与脂质组学合作共享资源，介绍蛋白质、脂质和糖的空间分析和成像新技术罐在患者的肿瘤组织中。通过将组织病理学与脂质、糖和蛋白质的表征联系起来 BTA 为 HCC 研究人员彻底改变研究提供了机会 mor 组织分析并确定以前未被识别的治疗途径。自 2013 年以来，BTA 已从患有实体瘤的患者身上收集了超过 26,500 个与癌症相关的生物样本。肿瘤和血液恶性肿瘤，所有这些都带有注释并与临床数据相关联。一个值得注意的特点是 BTA 的真正优势在于其能够定制样本的采集以满足 HCC 研究人员的特定需求。当前- 目前，25% 的 BTA 组织捐献者是非裔美国患者，他们在生物重组中的代表性通常不足。实验室和癌症研究。在当前资助期内，BTA 支持了 49 项研究 HCC 研究人员发表了 30 篇出版物和 20 份资助申请。 BTA 已产生影响为推进 HCC 癌症研究做出贡献，包括鉴定来自服务不足的样本具有海岛血统的患者以及使用 MALDI 成像来研究癌症中的蛋白质糖基化模式 cer。除了为越来越多的 HCC 研究人员提供服务外，BTA 还为主要的国家生物研究做出了贡献。存储库工作，包括 NCI 资助的患者衍生异种移植物 (PDX) 存储库、NCI 资助的合作社活跃的人体组织网络，以及国防部资助的多中心 NCORP 种族和民族多样化早发存储库。在常染色体领域专家 Steven L. Carroll 医学博士、哲学博士的领导下由于 1 型肿瘤易感综合征神经纤维瘤病，BTA 已成为一个种族丰富且多元化的群体相反的肿瘤组织生物样本库，为 HCC 研究人员提供了重要的科学资源致力于将基本生物学发现与人类癌症的预防、临床诊断和治疗联系起来。