Detroit Research on Cancer Survivors (Detroit ROCS)

底特律癌症幸存者研究（底特律 ROCS）

• 批准号: 10590760
• 负责人: Jennifer L Beebe-Dimmer
• 金额: $ 105.2万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-27 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590760
• 关键词: Address; Affect; African American; African American population; Aftercare; Age; Aging; Anxiety; Back; Biological; COVID-19 impact; Cancer Etiology; Cancer Prognosis; Cancer Survivor; Caring; Cessation of life; Collaborations; Colorectal Cancer; Communities; Community Outreach; Community Participation; Complex; Data; Development; Diagnosis; Disease; Early Diagnosis; Early treatment; Endometrial Carcinoma; Enrollment; Ethnic Population; Event; Family; Financial Hardship; Funding; Geography; Goals; Grant; Health; Health behavior; Incidence; Institution; Investigation; Link; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measures; Medical; Medical History; Medical Records; Mental Depression; Mutation; Neighborhoods; Not Hispanic or Latino; Outcome; Paper; Patients; Periodicals; Population; Population Heterogeneity; Publishing; Quality of life; Recording of previous events; Recurrence; Recurrent disease; Registries; Reporting; Research; Research Priority; Resources; Second Primary Cancers; Sociology; Source; Surveys; Survivors; System; Treatment outcome; United States Centers for Medicare and Medicaid Services; United States National Institutes of Health; Update; Work; actigraphy; cancer diagnosis; cancer health disparity; cancer therapy; cohort; community engagement; comorbidity; disparity gap; early onset; end of life care; experience; financial toxicity; follow-up; health equity; improved; malignant breast neoplasm; member; metropolitan; mortality; outcome disparities; participant enrollment; participant retention; patient population; population based; primary caregiver; psychologic; racial population; side effect; sleep health; sociodemographics; survivorship; treatment adherence; tumor; tumor progression

Project Summary/Abstract Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The Detroit Research on Cancer Survivors (ROCS) study (U01CA199240) is the largest single cohort of African American cancer survivors aimed at understanding the multiplex causes of poorer outcomes in this population. Detroit ROCS has been collecting survey data and biospecimens with a goal of enrolling 5,000 population-based African Americans diagnosed with lung, breast, prostate, colorectal, and endometrial cancers and any early- onset cancer (diagnosed age 20-49 years) and supporting studies addressing determinants of cancer outcomes and quality of life. In this renewal application, we will continue to follow cohort survivors annually for up to 9 years to address the determinants of longer term outcomes (e.g., disease recurrence, second primary diagnoses, treatment related comorbidities and death) and quality of life. The broad research agenda will be developed with our community partners. We propose to: 1) conduct annual follow-up surveys on all living, enrolled participants for up to five additional years and collect additional biospecimens; 2) engage with members of the community to set new research priorities and to obtain input into the retention of participants and dissemination of research findings back to the community; 3) link Detroit ROCS patient data to other existing sources of health-related and exposure data to supplement patient-reported information; and 4) extend collaborations to facilitate use of the data and biospecimens by the broader research community. Detroit ROCS is providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population.

项目概要/摘要 尽管在早期检测和治疗方面取得了进展，非裔美国人仍然面临着 癌症发病率不成比例地较高，首先被诊断出患有更晚期的疾病， 并且死亡率高于其他人群。底特律癌症幸存者研究 (ROCS) 研究 (U01CA199240) 是针对非洲裔美国癌症幸存者的最大单一队列 了解导致该人群预后较差的多重原因。底特律 ROCS 已 收集调查数据和生物样本，目标是招募 5,000 名非洲人口 被诊断患有肺癌、乳腺癌、前列腺癌、结直肠癌和子宫内膜癌以及任何早期癌症的美国人 癌症发病年龄（诊断年龄 20-49 岁）和解决癌症决定因素的支持研究 结果和生活质量。在此更新申请中，我们将继续跟踪队列幸存者 每年一次，持续长达 9 年，以解决长期结果的决定因素（例如，疾病 复发、第二次初步诊断、治疗相关合并症和死亡）和生活质量。 广泛的研究议程将与我们的社区合作伙伴一起制定。我们建议：1）进行 对所有活着的登记参与者进行年度跟踪调查，最多持续五年，并收集 额外的生物样本； 2）与社区成员合作确定新的研究重点 获取有关保留参与者和将研究成果传播回组织的意见 社区; 3) 将底特律 ROCS 患者数据链接到其他现有的健康相关和暴露来源 补充患者报告信息的数据； 4) 扩大合作以促进使​​用 更广泛的研究界的数据和生物样本。底特律 ROCS 正在提供大量数据 和生物样本，以促进旨在了解和解决贫困决定因素的研究 该人群的结果。