Population Studies and Disparities Research

人口研究和差异研究

基本信息

批准号：
10348665
负责人：
Jennifer L Beebe-Dimmer
金额：
$ 3.88万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-08 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10348665
关键词：
Address Admixture Adult Affect African American American Arabs Area Automobile Driving Behavioral Cancer Center Support Grant Cancer Survivor Cancer Survivorship Catchment Area Characteristics Childhood Clinic Clinical Cohort Studies Collaborations Colon Carcinoma Communication Communication Research Communities Comprehensive Cancer Center Custom Data Development Diagnosis Discrimination Disease Progression Endometrial Carcinoma Epidemiology Epigenetic Process Ethnic Origin Evidence based intervention Family member Funding Future Genetic Goals Grant Health Heritability Immunity Incidence Individual Inflammation Intervention Investigation Lesbian Gay Bisexual Transgender Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of ovary Malignant neoplasm of prostate Manuscripts Metabolic syndrome Michigan Minority Minority Groups Mission Molecular Molecular Epidemiology of Cancer Molecular Genetics Obesity Onset of illness Outcome Participant Patient-Focused Outcomes Patients Pattern Peer Review Physical activity Physicians Population Population Heterogeneity Population Study Prognosis Publishing Quality of Care Race Reduce health disparities Research Research Project Grants Resources Risk Risk Behaviors Risk Factors Role Rural Rural Population SEER Program Schools Sexual and Gender Minorities Site Smoking Survivors Susceptibility Gene System Targeted Research Technology Testing Treatment outcome Underserved Population United States Universities Work analytical method base biomarker discovery cancer diagnosis cancer epidemiology cancer health disparity cancer prevention cancer risk clinical practice clinical research site cohort community based research comorbidity defined contribution design disparity elimination disparity reduction eHealth end of life ethnic diversity experience family genetics gender minority group health equity high risk high risk population improved interest malignant breast neoplasm medically underserved member metropolitan mortality neoplasm registry novel outreach patient-clinician communication population based population health preclinical study programs provider behavior psychosocial racial bias racial diversity recruit risk stratification screening social survivorship symptom management theories treatment choice tumor

项目摘要

POPULATION STUDIES AND DISPARITIES RESEARCH – ABSTRACT The Population Studies and Disparities Research (PSDR) Program is committed to identifying key genetic and behavioral risk factors underlying disease onset and progression and developing and testing novel intervention strategies to reduce risk and improve diagnosis, treatment, and outcomes with an emphasis on reducing and/or eliminating cancer health disparities among populations contained within our catchment area. This interactive Program includes 28 members from 11 departments and 3 schools at Wayne State University and $6,936,093 in peer reviewed, cancer-related funding, of which $5,793,590 is from the NCI. The PSDR Program has two overarching scientific themes. The first theme is to investigate the distribution and determinants of cancer risk, survivorship, and outcomes in a racially and ethnically diverse population. Major scientific investigations under this theme use emerging advances in genetics to address our highly-diverse catchment area population that is approximately 25% African American, includes the largest Arab-American community in the US; developing projects target both sexual and gender minority cancer survivors and rural populations within our expanded catchment area. The work is supported by the Detroit area population-based cancer registry, a founding participant in the SEER Program, a resource that is well-leveraged for extensive population-based studies of the epidemiology of lung, breast, prostate, colon, ovarian, and endometrial cancers in diverse populations. The second theme is to develop and test evidence-based interventions focused on patient, family member, and physician behaviors to reduce disparities in cancer prevention, treatment, survivorship, and end-of-life outcomes. The main focus of this theme is modifying social and behavioral factors driving risk behaviors, screening and treatment choices, the quality of physician-patient-family member communication, symptom management, and survivorship in racially and ethnically diverse adult and pediatric populations. The work is supported by a unique, custom-designed video data capture system installed in multiple clinic sites to study the ways racial bias and poor communication give rise to unequal treatment decisions and health outcomes. Future directions include the development of multi-PI grants focused on African American cancer survivors, leveraging the Detroit Research on Cancer Survivors (Detroit ROCS) cohort study. The Detroit ROCS study is the largest single cohort conducted exclusively among African American cancer survivors with a goal of understanding the determinants of poorer outcomes in this population. eHealth technologies to enhance patient-provider communication are also being developed. PSDR Program members actively collaborate with members of the MI, MT, and TBM Programs at KCI. Of the 409 manuscripts published from December 2015 to November 2019, 43% and 25% were intra- and inter-programmatic, respectively, and 74% were multi- institutional collaborations.

人口研究和差异研究——摘要人口研究和差异研究 (PSDR) 计划致力于识别关键遗传因素和行为风险因素是疾病发生和进展的基础，以及开发和测试新的降低风险并改善诊断、治疗和结果的干预策略，重点是减少和/或消除我们流域内人口之间的癌症健康差异。这个互动项目包括来自韦恩州立大学 11 个系和 3 个学院的 28 名成员 6,936,093 美元的同行评审癌症相关资金，其中 5,793,590 美元来自 NCI。计划有两个总体科学主题，第一个主题是调查分布和分布。种族和民族多样化人群中癌症风险、生存率和结果的决定因素。这一主题下的科学研究利用遗传学的新兴进展来解决我们高度多样化的问题流域人口中大约 25% 是非裔美国人，其中包括最大的阿拉伯裔美国人美国社区；针对性少数和性别少数癌症幸存者和农村地区制定项目这项工作得到了底特律地区人口的支持。癌症登记处，SEER 计划的创始参与者，该资源可充分利用于广泛的基于人群的肺癌、乳腺癌、前列腺癌、结肠癌、卵巢癌和子宫内膜癌流行病学研究第二个主题是开发和测试以证据为基础的干预措施。患者、家庭成员和医生的行为，以减少癌症预防、治疗、该主题的主要重点是改变社会和行为因素。推动风险行为、筛查和治疗选择、医生-患者-家庭成员的质量不同种族和民族的成人和儿童的沟通、症状管理和生存这项工作得到了安装在多个人群中的独特、定制设计的视频数据采集系统的支持。诊所站点研究种族偏见和沟通不畅导致不平等治疗决策的方式未来的方向包括开发针对非裔美国人的多 PI 赠款。癌症幸存者，利用底特律癌症幸存者研究 (底特律 ROCS) 队列研究。 ROCS 研究是在非裔美国癌症幸存者中进行的最大的单一队列研究，专门针对目标是了解该人群预后较差的决定因素，以加强电子卫生技术。 PSDR 计划成员也积极合作，建立患者与提供者之间的沟通。 KCI 的 MI、MT 和 TBM 项目成员自 2015 年 12 月起发表的 409 篇手稿中。截至 2019 年 11 月，分别有 43% 和 25% 是计划内和计划间的，74% 是多计划的机构合作。