A Patient-Oriented Research Program in Geriatric Oncology

以患者为中心的老年肿瘤学研究项目

基本信息

批准号：
10590987
负责人：
Supriya G. Mohile
金额：
$ 16.75万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10590987
关键词：
Advanced Malignant Neoplasm Advocate Affect Aging American Society of Clinical Oncology Award Caregivers Caring Clinic Clinical Clinical Oncology Clinical Trials Cluster randomized trial Communication Communication Research Community Clinical Oncology Program Contracts Data Data Analyses Data Set Decision Making Dose Effectiveness Elderly Endowment Exclusion Fostering Funding Geriatric Assessment Goals Grant Growth Guidelines Health Health Status High-Risk Cancer Hospitalization Intervention Investigation K-Series Research Career Programs Knowledge Lead Leadership Learning Low Prevalence Malignant Neoplasms Manuscripts Medicine Mentors Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Modification Oncologist Oncology Outcome Outcomes Research Patient Outcomes Assessments Patient-Focused Outcomes Patients Polypharmacy Principal Investigator Procedures Prognosis Publishing Randomized Recommendation Relative Risks Reporting Research Research Personnel Resources Risk Scientist Site Symptoms Testing Time Toxic effect Training Support Treatment Protocols Treatment-related toxicity United States National Institutes of Health Universities Woman adverse outcome cancer clinical trial cancer therapy career career development chemotherapy clinical care clinical practice comorbidity editorial falls functional improvement health assessment implementation evaluation implementation science implementation strategy improved improved outcome interest older patient oncology program patient oriented patient oriented research programs provider factors randomized, clinical trials satisfaction secondary analysis skills standard of care success treatment risk uptake

项目摘要

PROJECT SUMMARY The principal investigator (PI), Dr. Supriya Mohile, of this K24 renewal proposal leads an independently funded patient-oriented geriatric oncology research program at the University of Rochester Wilmot Cancer Institute. Over the last K24 funding period, Dr. Mohile completed two large multi-site cluster-randomized trials that evaluated whether geriatric assessment and management (GAM) improves outcomes of older patients with advanced cancer. GAM, a validated patient-centered approach for assessing health status, identifies older patients with cancer who are at risk of adverse outcomes and guides management for cancer treatment and for aging-related conditions. Both trials demonstrated, for the first time, that a GAM intervention improves patient- centered outcomes (communication and patient/caregiver satisfaction) and clinical outcomes (treatment toxicity, falls, and polypharmacy). Integrally involved in this research, mentees at the University of Rochester and through the Cancer and Aging Research Group (CARG) have utilized data from the GAM trials to successfully compete for their own career development and independent awards. Of the ten early career scientists that Dr. Mohile currently mentors at the University of Rochester, eight are women and four identify as underrepresented in medicine. Mentees have received over 20 grants and have published over 80 manuscripts with Dr. Mohile. Dr. Mohile is currently a primary mentor or co-mentor on seven career development awards. Further, over the last K24 funding period, Dr. Mohile successfully competed for three new R-level awards as PI from the Patient Centered Outcomes Research and the National Institutes of Health to evaluate strategies for implementing GAM in oncology practices and to expand understanding about cancer treatment tolerability in older adults. The original K24 allowed Dr. Mohile and her mentees to enhance skills in communication research; the renewal will allow them to learn about implementation science and leadership with expert consultants at the University of Rochester and in CARG. The overarching aims of this proposal are: 1) to develop and evaluate implementation strategies for GAM in oncology practices; and 2) to examine treatment tolerability in older patients with advanced cancer and aging-related conditions starting a new high-risk cancer treatment regimen. This research will have a positive impact by providing information on pragmatic mechanisms for implementing GAM in oncology care. Importantly, this proposal will allow for the career development of mentees pursuing patient-oriented research focused on geriatric oncology, an understudied field. Through funded research, an endowment from the Wilmot Cancer Institute, and the NIA-funded CARG (MPI: Mohile), Dr. Mohile has the resources to continue to foster the careers of investigators interested in geriatric oncology research across the academic career trajectory. The renewal of this K24 Award will enable Dr. Mohile to expand mentoring to enhance the growth of patient-oriented research in geriatric oncology.

项目概要这项 K24 更新提案的首席研究员 (PI) Supriya Mohile 博士领导了一个独立资助的项目罗切斯特大学威尔莫特癌症研究所以患者为导向的老年肿瘤学研究项目。在上一个 K24 资助期间，Mohile 博士完成了两项大型多站点集群随机试验，评估老年评估和管理（GAM）是否可以改善老年患者的预后晚期癌症。 GAM 是一种经过验证的以患者为中心的健康状况评估方法，可识别老年人面临不良后果风险的癌症患者，并指导癌症治疗和治疗的管理与衰老相关的情况。这两项试验首次证明，GAM 干预可以改善患者的以中心结果（沟通和患者/护理人员满意度）和临床结果（治疗毒性、跌倒和复方用药）。罗切斯特大学的学员全面参与了这项研究并通过癌症与衰老研究小组 (CARG) 利用 GAM 试验的数据成功争夺自己的职业发展和独立奖项。十大早期职业生涯莫希勒博士目前在罗彻斯特大学指导的科学家中，八名是女性，四名被认为是在医学领域的代表性不足。学员已获得 20 多项资助并发表了 80 多篇手稿与莫希勒博士。 Mohile 博士目前是七个职业发展奖项的主要导师或共同导师。此外，在上一个 K24 资助期间，Mohile 博士作为 PI 成功竞争了三个新的 R 级奖项来自以患者为中心的结果研究和美国国立卫生研究院评估策略在肿瘤学实践中实施 GAM 并扩大对癌症治疗耐受性的了解老年人。最初的 K24 让 Mohile 博士和她的学员增强了沟通技巧研究;更新将使他们能够与专家一起学习实施科学和领导力罗切斯特大学和 CARG 的顾问。该提案的总体目标是：1）制定并评估 GAM 在肿瘤学实践中的实施策略； 2) 检查治疗患有晚期癌症和衰老相关疾病的老年患者开始新的高风险癌症的耐受性治疗方案。这项研究将通过提供实用信息来产生积极影响在肿瘤护理中实施 GAM 的机制。重要的是，该提案将使职业生涯培养以患者为中心的研究重点的受训者，重点关注老年肿瘤学，这是一个尚未得到充分研究的领域场地。通过资助的研究、威尔莫特癌症研究所的捐赠以及 NIA 资助的 CARG （MPI：Mohile），Mohile 博士拥有资源来继续培养对以下领域感兴趣的研究人员的职业生涯：整个学术生涯轨迹的老年肿瘤学研究。 K24 奖的续展将使 Mohile 博士将扩大指导范围，以促进老年肿瘤学中以患者为导向的研究的发展。