Research Training in Renal Disease

肾病研究培训

• 批准号: 7791132
• 负责人: WILLIAM Evans MITCH
• 金额: $ 5.76万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791132
• 关键词: Kidney Diseases; Research Training; Kidney Diseases; Research Training

DESCRIPTION (provided by applicant):The objective of this training program is to provide superb training of bright, young physician-scientists to develop the necessary skills to conduct state-of-the-art basic and translational research in the field of nephrology. The emphasis of the program is to provide training in the experimental design, methodology, and analyses of research aimed at elucidating mechanisms of renal injury and scarring as it relates to renal diseases associated with hypertension, diabetes, glomerular disease, and other renal conditions. The ultimate goal is to train physician-scientists to become independent investigators in academic nephrology. To achieve this objective, a multidisciplinary program has been developed to provide individualized training to postdoctoral candidates. Selected candidates develop a research project in concert with both a Nephrology and Basic Science mentor and undertake a minimum of two and preferably 3 years of research in their respective laboratories. A strong didactic program is also provided to ensure teaching in experimental design, molecular biologic methodology, biostatistics, and ethics. The emphasis of the program centers on several major areas of renal inflammation and fibrosis. These include the role of effector cells (macrophages and T cells) and their mechanisms of recruitment and dispersal, including the biology of chemokines, leukocyte adhesion molecules, the Slit/Robo chemorepellant molecules, monocyte/macrophage migration inhibition factor, and macrophage activation, proliferation and apoptosis. The cellular mechanisms involved in the renal response to injury will also be studied in detail, including the role of impaired angiogenesis, tubular apoptosis, and mechanisms of fibrosis. The latter includes the role of cytokines (IL-1beta and TNFalpha), TGF-beta/Smad signaling, the role of MAP kinases, and of the ubiquitination/proteasomal system in cytokine receptor degradation and cytokine unresponsiveness. Additional emphasis is placed on mechanisms of smooth muscle cell injury and proliferation in the kidney, particularly as it relates to the development of hypertension, and the various biochemical (such as uric acid) and vasoactive mediators (such as stanniocalcin) that influence smooth muscle cell proliferation, migration, hypertrophy and contraction. The interdisciplinary, multi-faceted plan integrates several important fields (biochemistry, immunology, physiology and pathology) to dissect structure function relationships linking basic cellular signaling and molecular mechanisms with translational research in animal models of disease.

描述（由申请人提供）：该培训计划的目的是提供对年轻，年轻医师科学家的精湛培训，以开发必要的技能，以在肾脏科领域进行最先进的基本和转化研究。该计划的重点是提供旨在阐明肾脏损伤机制的研究，方法论和研究分析的培训，因为这与与高血压，糖尿病，肾小球疾病和其他肾脏疾病有关的肾脏疾病有关。最终目标是培训医师科学家，成为学术肾脏病的独立研究人员。为了实现这一目标，已经制定了一个多学科计划，以为博士后候选人提供个性化的培训。选定的候选人与肾脏病和基础科学指导者共同开发了一个研究项目，并至少在其各自的实验室进行了至少两年的研究。还提供了一个强大的教学计划，以确保实验设计，分子生物学方法论，生物统计学和伦理学的教学。该计划的重点集中在肾脏炎症和纤维化的几个主要领域。这些包括效应细胞（巨噬细胞和T细胞）的作用及其募集和分散机制，包括趋化因子的生物学，白细胞粘附分子，裂缝/Robo化学层分子，单核细胞/巨噬细胞迁移抑制因子，以及巨噬细胞的生物，以及巨噬细胞的活化，碱性激活，倍增和猿类。还将详细研究参与肾脏损伤反应的细胞机制，包括血管生成受损，管状细胞凋亡和纤维化机制的作用。后者包括细胞因子（IL-1BETA和TNFALPHA），TGF-BETA/SMAD信号，MAP激酶的作用以及泛素化/蛋白酶体系统在细胞因子受体降解和细胞因子无反应性中的作用。额外的重点放在肾脏平滑肌细胞损伤和增殖的机制上，尤其是与高血压的发展有关，以及各种生化（例如尿酸）和血管活性介质（例如Stanniocalcin）影响平滑肌细胞增殖，迁移，迁移，超高和构造。跨学科的多方面计划将几个重要领域（生物化学，免疫学，生理和病理学）整合在一起，以剖析结构功能关系，将基本细胞信号传导和分子机制与动物模型中的转化研究联系起来。