Renal Inflammation: Mechanisms and Consequences

肾脏炎症：机制和后果

基本信息

批准号：
7230971
负责人：
WILLIAM Evans MITCH
金额：
$ 98.58万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-01 至 2010-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7230971
关键词：
Renal Inflammation Mechanisms Consequences

项目摘要

DESCRIPTION (provided by applicant) The O'Brien Center for Renal Inflammation has the mission of furthering our understanding of the mechanisms involved in the initiation, maintenance, and resolution of inflammation in renal disease. Renal inflammation is recognized to have a critical role in the pathogenesis of acute renal failure, glomerulonephritis, diabetic nephropathy, hypertension, and progressive renal disease. In this Center application, we have brought together scientists with expertise in different aspects of inflammation to provide a cohesive and comprehensive investigation of the mechanisms involved in renal inflammation. The multidisciplinary approach will focus on both proinflammatory and anti-inflammatory mechanisms with an emphasis on molecules that have either not received much attention (e.g., uric acid) or that have only recently been identified as having a role in inflammation. The latter includes new chemokines (CXCL16), new adhesion molecules (JAM family), the recently discovered Slit/Robo family, the signaling molecule Smad7, and stanniocalcin. A pathology core that focuses on the role of these molecules in human disease will provide clinical relevance and will be a mechanism for translating basic science observations for potential future clinical research application. The Center will also train fellowship candidates for a career in academic nephrology (in concert with a T-32 training grant which is currently under review), help initiate the careers of junior investigators (via the DR/P&F program), and provide a strong interaction with the other Centers at Baylor that also focus on the inflammatory response (such as the Biology of Inflammation Center). The integrated, multidisciplinary, synergistic and comprehensive approach to study renal inflammation should provide a better understanding of the pathogenesis of renal disease and may provide new therapeutic insights.

描述（由申请人提供）奥布莱恩肾脏炎症中心的使命是进一步了解我们对肾脏疾病炎症起始，维持和解决涉及的机制的理解。肾脏炎症被认为在急性肾衰竭，肾小球肾炎，糖尿病性肾病，高血压和进行性肾脏疾病的发病机理中起关键作用。在此中心应用中，我们将具有炎症不同方面的专业知识的科学家汇集在一起，以对肾脏炎症所涉及的机制进行凝聚和全面的研究。多学科的方法将集中于促炎和抗炎机制，重点是对没有得到太多关注的分子（例如尿酸），或者直到最近才被确定为在炎症中起作用。后者包括新的趋化因子（CXCL16），新的粘附分子（JAM家族），最近发现的缝隙/机器人家族，信号分子SMAD7和Stanniocalcin。侧重于这些分子在人类疾病中的作用的病理核心将提供临床相关性，并将成为转化基础科学观察结果的机制，以进行潜在的未来临床研究应用。该中心还将培训奖学金候选人的学术肾脏病职业（与目前正在审查的T-32培训补助金一起），有助于启动初级调查人员的职业（通过DR/P＆F计划），并与Baylor的其他中心进行了牢固的互动，并重点介绍了炎症反应（例如，炎症中心）。研究肾脏炎症的综合，多学科，协同和全面的方法应更好地了解肾脏疾病的发病机理，并可能提供新的治疗见解。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine.

DOI：
10.2337/db10-0207
发表时间：
2010-08
期刊：
Diabetes
影响因子：
7.7
作者：
Wang H;Liu D;Cao P;Lecker S;Hu Z
通讯作者：
Hu Z

Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice.

DOI：
10.1172/jci38770
发表时间：
2009-10-01
期刊：
The Journal of clinical investigation
影响因子：
0
作者：
Hu, Zhaoyong;Wang, Huiling;Mitch, William E
通讯作者：
Mitch, William E

AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan.

DOI：
10.1152/ajprenal.00452.2003
发表时间：
2004-09
期刊：
American journal of physiology. Renal physiology
影响因子：
0
作者：
Ann Wamsley-Davis;R. Padda;L. Truong;C. C. Tsao-C.;Ping Zhang;D. Sheikh-Hamad
通讯作者：
Ann Wamsley-Davis;R. Padda;L. Truong;C. C. Tsao-C.;Ping Zhang;D. Sheikh-Hamad

PTEN inhibition improves muscle regeneration in mice fed a high-fat diet.