Omics of Rheumatic Diseases among the Lakota Indians

拉科塔印第安人风湿病组学

• 批准号: 9146206
• 负责人: MICHAEL P. SNYDER
• 金额: $ 48.97万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9146206
• 关键词: Accounting; Adopted; American Indians; Attention; Autoimmune Diabetes; Autoimmune Process; Back; Big Data; Biocompatible Materials; Biological; Biological Models; Biology; Businesses; Climate; Collaborations; Collection; Communication; Communities; Community Health; Community Healthcare; Course Content; Data Base Management; Disease; Economics; Education; Educational Curriculum; Educational Models; Enrollment; Environmental Exposure; Ethics; Evaluation; Funding; Genetic; Genetic Research; Genetic study; Genome; Genotype; Geography; Head; Health; Health Benefit; Health Personnel; Health Sciences; Health education; Healthcare; Heart Diseases; Human; Human Resources; Immunologic Monitoring; Indian reservation; International; Interview; Knowledge; Language; Laws; Learning; Malignant Neoplasms; Methods; Monitor; Navajo; Participant; Pathway interactions; Pharmacogenetics; Pharmacologic Substance; Population; Practice Management; Process; Proteome; Protocols documentation; Questionnaires; Research; Research Design; Research Infrastructure; Reservations; Rheumatism; Rheumatoid Arthritis; Risk Assessment; Sampling; Science; Scientist; Secure; Sioux Indians; Site; South Dakota; Specimen; Technology; Testing; Teton Sioux Indian; Time; Training; Tribal group; Universities; Work; biobank; cohort; disorder risk; health data; health disparity; health literacy; improved; literacy; member; named group; precision medicine; programs; racial and ethnic; repository; research study; social; socioeconomics; transcriptome; transcriptomics; tribal Nation; tribal community; tribal health; tribal member

ABSTRACT: Project 1: BRAICELET- Bio-Repository for American Indian Capacity, Education, Law, Economics and Technology. To help reduce the myriad of health disparities in American Indian populations, this proposal's primary aim focuses on the establishment of the first tribally-owned biobank as a conduit for education on the benefits of precision medicine and big-data health science. Here, BRAICELET- Bio-Repository for American Indian Capacity, Education, Law, Economics and Technology will be initiated with the eminent Lakota Sioux community. This will serve as a proof of principle study on how educative and capacity building methods can promote long term self-sustainability and autonomy on advanced health care practices and management. The Stanford Biobank HIMC (Human Immune Monitoring Center) will act as a blueprint, whereby best lab protocols and secure database management programs will be adapted to include Lakota language and cultural/ceremonial practices. This proposal has the advantage of an ongoing collaboration with the Lakota community for an –omics study on rheumatoid arthritis (RA) called SAIL (Studies in Autoimmune Illnesses with the Lakota). As an extension of our SAIL partnership (AIM 2), an additional 200 samples will be accrued from the community and will act as the first bio-specimens that will be collected, tested (genotype and transcriptome partnered with Stanford) stored and managed at BRAICELET. A focus on progress and dissemination of this SAIL –omics work will be embedded in the third aim of this proposal. This will be done first through creating a health science literacy and education curriculum adopted from Stanford's “big data” course program and tailored to the Lakota grassroots community and health care workers. Courses will include big data ethics, disease risk assessment through –omics analysis and the advantages of pharmacogenetics. To monitor if genetics and precision medicine course information is effectively communicated with the Lakota members, a five point knowledge assessment method/questionnaire will be used with BRAICELET recruiters and SAIL participants. An iterative evaluation of this questionnaire will assess progress and actively implement improvements to the curriculum. The growing attention to environmental, climate/geography and socio-economic relationships with genetic health data is now at the national and international level. BRAICELET takes this into account with context of geography, culture and environmental exposure of one group, in one place. This greatly increases the power, validity and usefulness of conclusions from precision medicine research studies. A bio-repository is an opportunity for tribal nations to retain & manage their own biological material on-site and further learn and define for themselves the benefits of big-data health science. Undoubtedly, an American Indian representation, scientific/cultural/political exchange and perspective will be of great value.

摘要：项目1：美洲印第安人能力，教育，法律的胸骨疗法 经济学和技术。 为了减少美洲印第安人人口中无数的健康差异，该提议的主要目的 着重于建立第一个部落拥有的生物库，作为教育的渠道 精密医学和大数据健康科学。在这里，美洲印第安人的盲目生物叛逆者 能力，教育，法律，经济学和技术将由著名的Lakota Sioux社区发起。 这将作为有关教育和能力建设方法如何促进长时间研究的主要研究证明 对高级医疗保健实践和管理的术语自我可持续性和自治性。斯坦福大学 Biobank Himc（人类免疫监测中心）将充当蓝图，从而最佳实验室协议并确保安全 数据库管理程序将适应包括Lakota语言和文化/礼仪实践。 该提案具有与拉科塔社区进行的持续合作进行 - 组合研究的优势 类风湿关节炎（RA）称为帆（Lakota的自身免疫性疾病研究）。作为我们的延伸 SAIL合作伙伴关系（AIM 2），将从社区中积累另外200个样本，并将作为第一个 将收集，测试的生物特异性（基因型和与斯坦福合作的转录组）存储并存储 在Braicelet进行管理。专注于这种帆的进度和传播 - 组工作将嵌入 在该提议的第三个目标中。这将首先通过创建健康科学素养和教育来完成 斯坦福大学“大数据”课程计划采用的课程，并针对拉科塔基层社区量身定制 和卫生保健工作者。课程将包括大数据伦理，通过 - 学分析评估疾病风险评估 以及药物遗传学的优势。监视遗传学和精密医学课程是否为 有效地与Lakota成员进行了五点知识评估方法/问卷 将与盲文招聘人员和帆船参与者一起使用。对该问卷的迭代评估将 评估进度并积极实施课程的改进。越来越关注 与遗传健康数据有关的环境，气候/地理和社会经济关系 国家和国际一级。 Braicelet将其考虑到地理，文化和 一组的环境暴露在一个地方。这大大提高了力量，有效性和实用性 精确医学研究的结论。生物重复者是部落国家的机会 保留并管理自己的生物材料现场，并进一步学习和定义自己的好处 大数据健康科学。毫无疑问，美国印第安人的代表，科学/文化/政治交流 观点将具有很大的价值。