Core D - Biostatistics/Bioinformatics

核心 D - 生物统计学/生物信息学

• 批准号: 9149651
• 负责人: GIDEON D ZAMBA
• 金额: $ 26.48万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9149651
• 关键词: Adverse event; Archives; Area; Basic Science; Bioinformatics; Biometry; Chemistry; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Complement; Comprehensive Cancer Center; Computational Biology; Controlled Clinical Trials; Correlative Study; Data; Data Analyses; Data Collection; Databases; Development; Drug Kinetics; Engineering; Event; Experimental Designs; G-Protein-Coupled Receptors; Gene Chips; Gene Deletion; Gene Expression; Gene Mutation; Genome; Genomics; Genotype; Human; Human Resources; Image; Image Analysis; Individual; Informatics; Information Management; Iowa; Laboratories; Leadership; Malignant Neoplasms; Manuscripts; Monitor; Mutation; Nature; Neuroendocrine Tumors; Neurosecretory Systems; Normal tissue morphology; Outcomes Research; Pharmacology; Population; Population Sciences; Preparation; Procedures; Process; Public Health; Publications; Quality Control; Quality of life; Reading; Registries; Research; Research Design; Research Personnel; Resources; Safety; Sampling; Schools; Specialized Program of Research Excellence; System; The Cancer Genome Atlas; Therapeutic Trials; Tissues; Translational Research; Tumor Suppressor Genes; Tumor Tissue; Universities; Update; Work; abstracting; cancer genome; career development; college; data archive; data integration; data management; data sharing; database of Genotypes and Phenotypes; design; exome sequencing; experience; follow-up; genomic data; innovation; investigator training; neoplasm resource; next generation sequencing; programs; receptor expression; response; tissue registry; translational clinical trial; tumor; tumor registry

The Biostatistics and Bioinformatics Core provides integrative statistical and informatics support to the Iowa Neuroendocrine Tumor (NET) SPORE. This support is provided to the SPORE: projects, developmental projects and associated cores. The comprehensive nature of the Core encompasses basic, translational, and clinical projects, assuring each SPORE investigator access to expertise that includes development of study designs, state of the art data analysis and interpretation, data management resources, abstract and manuscript preparation, and synergistic interaction with all other core components through gate keeping and analyses information sharing. The Core builds upon the innovative procedures and systems in the University of Iowa Holden Comprehensive Cancer Center, the Department of Biostatistics in the College of Public Health and the Coordinated Laboratory for Computational Genomics in the School of Engineering. Design and analysis support has been and will be provided across a range of fields, including basic chemistry and pharmacology, exome sequencing and mutation discovery, expression analysis, imaging pharmacokinetics and dosimety, clinical trials, and population science. The Core designed, developed, and will continue to upgrade the Iowa Neuroendocrine Tumor Database. Support is also provided for the management and integration of existing and newly collected data through consistent and compatible genomic data handling. Additional areas of support for clinical trials include data form development and processing, data collection and entry, data archiving, quality control, and data safety monitoring. In addition to being actively involved with the preparation of statistical plans for the four projects in this application, the Core was also involved in the management of information pertaining to Exome sequencing, gene mutation identification and analysis of G-protein coupled receptor expression. The Core has and will continue to provide statistical experimental design, data analysis and management for all studies, and preparation of data summaries for manuscript publication. In summary, strengths of the Biostatistics and Bioinformatics Core are complete integration into, and synergistic interaction with, each of the SPORE projects and associated cores, the unique Iowa Neuroendocrine Tumor Database incorporating both genotypic and phenotypic information, and the breadth of expertise provided by the Biostatistics and Bioinformatics personnel.

生物统计学和生物信息学核心为爱荷华州提供了综合统计和信息学支持 神经内分泌肿瘤（净）孢子。此支持已提供给孢子：项目，发展性 项目和相关的核心。核心的全面性质包括基本，翻译和 临床项目，确保每个孢子研究者获得专业知识，包括研究的发展 设计，最新数据分析和解释的状态，数据管理资源，摘要和手稿 通过门保持和分析，准备和与所有其他核心组件的协同互动 信息共享。核心基于爱荷华大学的创新程序和系统 霍顿综合癌症中心，公共卫生学院生物统计学系和 工程学院的计算基因组学实验室。设计和分析 支持已经并且将在包括基本化学和药理学在内的一系列领域提供， 外显子组测序和突变发现，表达分析，成像药代动力学和分子， 临床试验和人群科学。核心设计，开发并将继续升级爱荷华州 神经内分泌肿瘤数据库。还提供了支持现有和整合的支持 新收集的数据通过一致和兼容的基因组数据处理。其他支持领域 临床试验包括数据形式开发和处理，数据收集和输入，数据归档，质量 控制和数据安全监控。除了积极参与统计的准备 该应用程序中四个项目的计划，核心也参与了信息管理 与外显子组测序，基因突变鉴定和G蛋白偶联受体的分析有关 表达。核心已经并且将继续提供统计实验设计，数据分析和 所有研究的管理以及编写手稿出版的数据摘要。总之， 生物统计学和生物信息学核心的优势是完全集成到协同的相互作用中 在每个孢子项目和相关的核心中，都独特的爱荷华州神经内分泌肿瘤数据库 纳入基因型和表型信息，以及由 生物统计学和生物信息学人员。