UT Southwestern Center for Translational Medicine

德州大学西南转化医学中心

• 批准号: 10614619
• 负责人: ROBERT Daniel TOTO
• 金额: $ 793.3万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-26 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614619
• 关键词: Acceleration; Address; Adoption; Artificial Intelligence; Basic Science; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Data; Data Collection; Education; Ensure; Entrepreneurship; Environment; Faculty; Family; Fostering; Foundations; Funding; Goals; Health; Health Personnel; Healthcare; Healthcare Systems; Heterogeneity; Individual; Industry; Informatics; Institution; Intervention; Leadership; Longevity; Mentors; Methods; Mission; Outcome; Patients; Phase; Policy Maker; Population; Population Heterogeneity; Process; Published Comment; Qualitative Methods; Reproducibility; Research; Resources; Rural Community; Rural Population; Science; Scientist; Services; Special Population; Teaching Hospitals; Technology; Testing; Texas; Training; Training Programs; Training and Education; Translating; Translation Process; Translational Research; Translations; Underserved Population; Urban Community; Urban Population; academic program; biomedical scientist; catalyst; clinical practice; collaborative environment; community engagement; design; equity, diversity, and inclusion; ethnic diversity; improved; informatics training; innovation; member; multimodality; novel; novel strategies; personalized medicine; point of care; population health; pre-clinical; programs; racial diversity; recruit; research to practice; skills; success; tool; translational medicine; user-friendly

Contact PD/PI: Toto, Robert D OVERALL: PROJECT SUMMARY/ABSTRACT The Center for Translational Medicine (CTM) at UT Southwestern is a collaboration among 7 academic institutions, 5 health care systems, 6 teaching hospitals and the North Texas community. Our mission is to improve health in local and global communities through innovation and education. Over the past two funding cycles, our CTSA catalyzed innovation and transformed the culture and landscape of our program Hub. We have trained >1,000 members of the translational workforce, co-led the formation of the Accrual to Clinical Trials CTSA network and established new translational technologies, methods, and processes critical to the translational process at every level. We engaged our local communities early on in the design and conduct of clinical research. We also formed new collaborative research services and education and training programs designed to address the top health challenges of our community and the nation. Through these efforts, the CTM has generated considerable momentum toward advancing translational science propelled by a highly collaborative environment that is hard-wired for Team Science and Community Engagement. Over the next 5 years, we will optimize the organization of our CTSA Hub for more efficient translation of biomedical discoveries into interventions that will ultimately result in the improved health of both our local populations and, in collaboration with the CTSA Network, the broader U.S. population. We will discover, develop, demonstrate, and disseminate new informatics and artificial intelligence solutions to challenging problems in translation at all levels. In collaboration with Hub partners and relevant national CTSA networks, we propose to develop new methods and processes to further the integration of research into practice at the point of care. Building on our success, we are now poised to achieve the five key objectives of the CTSA Program and the Center for Translational Medicine with the following Specific Aims: Aim 1. Produce a well-trained, highly skilled, diverse Translational Workforce. Aim 2. Inculcate Community Engagement and Team Science. Aim 3. Integrate diverse populations across the lifespan into clinical and translational research. Aim 4. Promote innovation and new scientific Methods and Processes. Aim 5. Develop innovative Informatics solutions to overcome translational roadblocks. Aim 6. Increase Workforce Heterogeneity. Impact: With our highly-integrated dynamic research and training environment in place, our Hub will have a powerful and sustained impact on the field of translational science. We will make a major leap forward in the scope, efficiency, and quality of clinical and translational research for the benefit of our Hub and the national consortium. We will collaborate with the Center for Leading Innovation and Collaboration, the Trial Innovation Network, and the Center for Data to Health to bridge the gap between scientific discovery and improved health. Project Summary/Abstract Page 164 Contact PD/PI: Toto, Robert D O. OVERALL:

联系人 PD/PI：Toto, Robert D 总体而言：项目摘要/摘要 UT Southwestern 的转化医学中心 (CTM) 是 7 个学术机构的合作项目 机构、5 个医疗保健系统、6 所教学医院和北德克萨斯社区。我们的使命是 到 通过创新和教育改善当地和全球社区的健康。 过去两次融资 我们的 CTSA 促进了创新并改变了我们项目中心的文化和景观。我们 培训了超过 1,000 名翻译人员，共同领导了应计到临床 (Accrual to Clinical) 的组建 试验 CTSA 网络并建立对以下领域至关重要的新转化技术、方法和流程 各个层面的翻译过程。我们很早就让当地社区参与了设计和实施 临床研究。我们还形成了新的合作研究服务以及教育和培训计划 旨在解决我们社区和国家面临的首要健康挑战。通过这些努力， 在高度的推动下，CTM 为推进转化科学产生了巨大的动力。 为团队科学和社区参与而生的协作环境。 未来 5 年，我们将优化 CTSA Hub 的组织，以提高翻译效率 将生物医学发现转化为干预措施，最终将改善我们当地的健康状况 人口，并与 CTSA 网络合作，覆盖更广泛的美国人口。我们会发现， 开发、演示和传播新的信息学和人工智能解决方案，以应对挑战 各个层面的翻译问题。与 Hub 合作伙伴和相关国家 CTSA 网络合作， 我们建议开发新的方法和流程，以进一步将研究与实践相结合 护理点。在我们成功的基础上，我们现在准备实现 CTSA 的五个关键目标 项目和转化医学中心的具体目标如下： 目标 1. 培养一支训练有素、技能精湛、多元化的转化型劳动力队伍。 目标 2. 灌输社区参与和团队科学。 目标 3. 将不同生命周期的人群纳入临床和转化研究。 目标 4. 促进创新和新的科学方法和流程。 目标 5. 开发创新的信息学解决方案以克服转化障碍。 目标 6. 增加劳动力的异质性。 影响：凭借我们高度集成的动态研究和培训环境，我们的中心将拥有 对转化科学领域产生强大而持续的影响。我们将在这方面取得重大飞跃 临床和转化研究的范围、效率和质量，以造福我们的中心和国家 财团。我们将与领先创新与协作中心、试验创新中心合作 网络和健康数据中心，以弥合科学发现和改善健康之间的差距。 项目总结/摘要第 164 页 联系人 PD/PI：Toto, Robert D O. 总体：

项目成果

56-year-old man • increased heart rate • weakness • intense sweating • horseradish consumption • Dx?

56 岁男性 → 心率加快 → 虚弱 → 大量出汗 → 食用辣根 → Dx？

• 发表时间: 2022-09
• 作者: Lehmann, Christoph U;Puckett, A Lynne;Betz, Barbara O
• 通讯作者: Betz, Barbara O

Controversies in the Prevention and Treatment of Clostridioides difficile Infection in Adults: A Narrative Review.

成人艰难梭菌感染预防和治疗的争议：叙述回顾。

• 发表时间: 2023-02-03
• 影响因子: 4.5
• 作者: Bainum, Taryn B;Reveles, Kelly R;Hall 2nd, Ronald G;Cornell, Kelli;Alvarez, Carlos A
• 通讯作者: Alvarez, Carlos A

Assessing Racial and Ethnic Bias in Text Generation for Healthcare-Related Tasks by ChatGPT1.

通过 ChatGPT1 评估医疗保健相关任务的文本生成中的种族和民族偏见。

• 发表时间: 2023-08-28
• 作者: Hanna, John J;Wakene, Abdi D;Lehmann, Christoph U;Medford, Richard J
• 通讯作者: Medford, Richard J

A pilot randomized controlled trial comparing nutritious meal kits and no-prep meals to improve food security and diet quality among food pantry clients.

一项随机对照试验，比较营养餐包和免准备餐，以提高食品储藏室客户的食品安全和饮食质量。

• 发表时间: 2023-12-01
• 影响因子: 4.5
• 作者: Hollis;Haskins, Carolyn;Turcios, Jessica;Bowen, Michael E;Leonard, Tammy;Lee, MinJae;Albin, Jaclyn;Wadkins;Thompson, Cynthia;Hall, Taylor;Pruitt, Sandi L
• 通讯作者: Pruitt, Sandi L

Identifying the Optimal Look-back Period for Prior Antimicrobial Resistance Clinical Decision Support.

确定先前抗菌素耐药性临床决策支持的最佳回顾期。

• 发表时间: 2023
• 作者: Hanna, John J;Wakene, Abdi D;Cooper, Lauren N;Diaz, Marlon I;Chen, Catherine;Lehmann, Christoph U;Medford, Richard J
• 通讯作者: Medford, Richard J